| PMID: |
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 (17428922)  |
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| title: |
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HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype |
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| author(s): |
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Asier Sáez-Cirión1, Christine Lacabaratz2, Olivier Lambotte2, 3, Pierre Versmisse1, Alejandra Urrutia2, Faroudy Boufassa4, Françoise Barré-Sinoussi1, Jean-François Delfraissy2, 3, Martine Sinet2, Gianfranco Pancino ( ) 1, Alain Venet2 |
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| laboratory: |
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| abstract: |
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Some rare HIV-1-infected individuals, referred to as HIV controllers (HIC), have persistently undetectable plasma viral load in the absence of therapy. This control of HIV-1 replication has been associated with a strong, multifunctional specific CD8(+) T cell response. However, no direct link between this immune response and the control of viremia has so far been provided. We investigated parameters of specific CD8(+) T cell response and in vitro susceptibility to HIV-1 infection in 11 HIC. We found high frequencies of HIV-specific CD8(+) T cells. Interestingly, these cells expressed the activation marker HLA-DR but not CD38. This unique phenotype differentiates HIV-specific CD8(+) T cells from HIC and noncontroller subjects and likely reflects a high potential to expand upon exposure to antigen and a capacity to exert effector functions. Accordingly, although CD4(+) T cells from HIC were fully susceptible to HIV-1 superinfection, their CD8(+) T cells effectively suppressed HIV-1 infection. Remarkably, this potent anti-HIV activity was observed without prior stimulation of CD8(+) T cells. This activity was not mediated by secreted inhibitory factors but was due to the elimination of infected CD4(+) T cells and was observed only with autologous CD4(+) T cells, indicating an HLA-restricted cytotoxic mechanism. This constitutive antiviral capacity of CD8(+) T cells could account for the control of viral replication in HIC. |
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| subject: |
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| fulltext language: |
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English |
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| publication format: |
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Article in peer-reviewed journal |
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| journal: |
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Proceedings of the National Academy of Sciences of the United States of America |
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| Audience: |
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international |
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| publication date: |
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2007-04-17 |
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| submission date: |
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2007-04-11 |
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| volume: |
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104 |
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| issue: |
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16 |
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| page, identifiant, ...: |
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6776-6781 |
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| keyword(s) of author: |
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"HIV suppression" – "CD8+ T cells " – "HLA-DR" – "CD38" |
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| contract, financing: |
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ANRS |
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