PMID: identifier of
Pubmed reference: |
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 (20460389)  |
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| title: |
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Overtime work and incident coronary heart disease: the Whitehall II prospective cohort study. |
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| author(s): |
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Marianna Virtanen ( ) 1, Jane Ferrie2, Archana Singh-Manoux2, 3, 4, Martin Shipley2, Jussi Vahtera1, 5, Michael Marmot2, Mika Kivimäki1, 2 |
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| laboratory: |
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| abstract: |
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AIMS: To examine the association between overtime work and incident coronary heart disease (CHD) among middle-aged employees. METHODS AND RESULTS: Six thousand and fourteen British civil servants (4262 men and 1752 women), aged 39-61 years who were free from CHD and worked full time at baseline (1991-1994), were followed until 2002-2004, an average of 11 years. The outcome measure was incident fatal CHD, clinically verified incident non-fatal myocardial infarction (MI), or definite angina (a total of 369 events). Cox proportional hazard models adjusted for sociodemographic characteristics showed that 3-4 h overtime work per day was associated with 1.60-fold (95% CI 1.15-2.23) increased risk of incident CHD compared with employees with no overtime work. Adjustment for all 21 cardiovascular risk factors measured made little difference to these estimates (HR 1.56, 95% CI 1.11-2.19). This association was replicated in multivariate analysis with only fatal cardiovascular disease and incident non-fatal MI as the outcome (HR 1.67, 95% CI 1.02-2.76). CONCLUSION: Overtime work is related to increased risk of incident CHD independently of conventional risk factors. These findings suggest that overtime work adversely affects coronary health. |
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| subject: |
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Life Sciences/Health Care Sciences and Epidemiology
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| fulltext language: |
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English |
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| ISSN: |
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0195-668X |
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| publication format: |
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Article in peer-reviewed journal |
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| DOI: |
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10.1093/eurheartj/ehq124 |
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| journal: |
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| European Heart Journal (Eur Heart J) |
| Publisher |
Oxford University Press (OUP): Policy B |
| ISSN |
0195-668X (eISSN : 1522-9645) |
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| Audience: |
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international |
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| publication date: |
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2010-07 |
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| submission date: |
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2010-05-11 |
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| volume: |
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31 |
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| issue: |
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14 |
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| page, identifiant, ...: |
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1737-44 |
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| keyword(s) of author: |
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working hours – stress – CHD – myocardial infarction – angina – middle-aged – prospective |
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| MeSH Descriptor(s): |
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Adult – Aged – Angina Pectoris – Cause of Death – Coronary Disease – Female – Humans – London – Male – Myocardial Infarction – Occupational Diseases – Prognosis – Prospective Studies – Risk Factors – Work Schedule Tolerance |
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| contract, financing: |
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The Whitehall II study has been supported by grants from the Medical Research Council; British Heart Foundation; Health and Safety Executive; Department of Health; National Heart Lung and Blood Institute (HL36310), US, NIH: National Institute on Aging (AG13196 and AG34454), US, NIH; Agency for Health Care Policy Research (HS06516); the John D and Catherine T MacArthur Foundation Research Networks on Successful Midlife Development and Socio-economic Status and Health; and the BUPA Foundation, UK. MK and JV are supported by the Academy of Finland (Projects no. #124271, #124322, #129262 and #132944), MK is additionally supported by the BUPA Foundation Specialist research grant, AS-M is supported by a 'EURYI' award from the European Science Foundation, MJS is supported by the British Heart Foundation and MGM is supported by a MRC Research Professorship. |
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| European projet: |
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| Cordis number |
38533 |
| Acronyme |
EURYI |
| Title |
Conférence : European Business Summit 2004 - Research and Innovation : A European Strategy for more growth and jobes |
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