Male circumcision and Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis: observations after a randomised controlled trial for HIV prevention.

Joelle Sobngwi-Tambekou; Dirk Taljaard; Marthi Nieuwoudt; Pascale Lissouba; Adrian Puren; Bertran Auvert

inserm-00375909, version 1

Male circumcision and Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis: observations after a randomised controlled trial for HIV prevention.
Sobngwi-Tambekou J., Taljaard D., Nieuwoudt M., Lissouba P., Puren A., Auvert B.
Sexually Transmitted Infections 85, 2 (2009) 116-20 - http://www.hal.inserm.fr/inserm-00375909

PMID: identifier of
Pubmed reference:

(19074928)

title:

Male circumcision and Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis: observations after a randomised controlled trial for HIV prevention.

author(s):

Joelle Sobngwi-Tambekou¹, Dirk Taljaard², Marthi Nieuwoudt³, Pascale Lissouba¹, Adrian Puren³, Bertran Auvert (

) ^{1, 4}

laboratory:

1:	Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé

http://www.u687.idf.inserm.fr/

INSERM : U687 – IFR69 – Université Paris XI - Paris Sud – Université de Versailles Saint-Quentin-en-Yvelines

Hôpital Paul Brousse 16, av Paul Vaillant Couturier 94807 VILLEJUIF

France

2:	Progressus

Progressus

Johannesburg

South Africa

3:	National Institute for Communicable Diseases

National Institute for Communicable Diseases

Johannesburg

South Africa

4:	Hôpital Ambroise Paré

Université de Versailles Saint-Quentin-en-Yvelines – Assistance publique - Hôpitaux de Paris (AP-HP)

9, avenue Charles-de-Gaulle 92100 Boulogne

France

abstract:

OBJECTIVE: To assess the association between male circumcision and Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis using data from a male circumcision randomised controlled trial. METHODS: We used data collected during the male circumcision trial conducted in Orange Farm (South Africa) among men aged 18-24 years. Altogether, 1767 urine samples collected during the final follow-up visit were analysed using PCR. Prevalence of N gonorrhoeae, C trachomatis and T vaginalis was assessed as a function of male circumcision using odds ratios (OR) given by univariate and multivariate logistic regression. RESULTS: In an intention-to-treat analysis, prevalence of N gonorrhoeae, C trachomatis and T vaginalis among intervention and control groups were 10.0% versus 10.3% (OR 0.97; p = 0.84), 2.1% versus 3.6% (OR 0.58; p = 0.065) and 1.7% versus 3.1% (OR 0.54; p = 0.062), respectively. The association between T vaginalis and male circumcision remained borderline when controlling for age, ethnic group, number of lifetime partners, marital status, condom use and HIV status (AOR 0.48; p = 0.069). In the as-treated analysis, this association became significant (OR 0.49, p = 0.030; AOR 0.41, p = 0.030). CONCLUSIONS: This study demonstrates for the first time that male circumcision reduces T vaginalis infection among men. This finding explains why women with circumcised partners are less at risk for T vaginalis infection than other women. The protective effect on T vaginalis is an additional argument to recommend male circumcision in Africa where it is acceptable.

subject:

Life Sciences/Health Care Sciences and Epidemiology

fulltext language:

English

ISSN:

1472-3263

publication format:

Article in peer-reviewed journal

DOI:

10.1136/sti.2008.032334

journal:

Sexually Transmitted Infections (Sex Transm Infect)
Publisher	BMJ Publishing Group
ISSN	1368-4973 (eISSN : 1472-3263)

Audience:

international

publication date:

2009-04

submission date:

2008-12-15

volume:

issue:

page, identifiant, ...:

116-20

Attached file list to this document:

PDF

116.pdf

(216.4 KB)


inserm-00375909, version 1
http://www.hal.inserm.fr/inserm-00375909
oai:www.hal.inserm.fr:inserm-00375909
From: Nadine Kaniewski <>
Submitted on: Thursday, 16 April 2009 13:18:45
Updated on: Thursday, 16 April 2009 13:34:40