PMID: identifier of
Pubmed reference: |
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 (19220143)  |
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| title: |
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Effect of HSV-2 serostatus on acquisition of HIV by young men: results of a longitudinal study in Orange Farm, South Africa. |
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| author(s): |
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Joelle Sobngwi-Tambekou1, Dirk Taljaard2, Pascale Lissouba1, Kevin Zarca1, Adrian Puren3, Emmanuel Lagarde4, Bertran Auvert ( ) 1, 5, 6 |
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| laboratory: |
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| abstract: |
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BACKGROUND: The objectives of this study were to assess the impact among young men of herpes simplex virus type 2 (HSV-2) status on the acquisition of human immunodeficiency virus (HIV) and on the protective effect of male circumcision against HIV acquisition. METHODS: We used data collected during a male circumcision trial conducted in Orange Farm, South Africa. We estimated adjusted incidence rate ratios (IRRs) for HIV acquisition, using survival analysis and background characteristics, HSV-2 status, male circumcision status, and sexual behavior as covariates. RESULTS: Compared with subjects who remained HSV-2 negative throughout the study, subjects who were HSV-2 positive at enrollment had an adjusted IRR of 3.3 (95% confidence interval [CI], 1.5-7.4; P=.004), and those who became HSV-2 positive during follow-up had an adjusted IRR of 7.0 (95% CI, 3.9-12.4; P<.001). The population fraction of incident HIV infection attributable to HSV-2 was 27.8% (95% CI, 17.7%-37.2%). Intention-to-treat analysis of the protective effect of male circumcision on HIV acquisition was the same among men with and men without HSV-2 (0.38 vs. 0.37; P=.93). CONCLUSIONS: This study shows that HSV-2 has a substantial impact on HIV acquisition among young South African men. It suggests that HSV-2 infection enhances HIV acquisition and is responsible for approximately 25% of incident cases of HIV infection. However, the protective effect of male circumcision against HIV acquisition appears independent of HSV-2 serostatus. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00122525. |
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| subject: |
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Life Sciences/Health Care Sciences and Epidemiology
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| fulltext language: |
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English |
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| ISSN: |
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0022-1899 |
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| publication format: |
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Article in peer-reviewed journal |
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| DOI: |
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10.1086/597208 |
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| journal: |
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The Journal of Infectious Diseases |
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| Audience: |
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international |
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| publication date: |
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2009-04-01 |
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| volume: |
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199 |
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| issue: |
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7 |
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| page, identifiant, ...: |
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958-64 |
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