PMID: identifier of
Pubmed reference: |
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 (18591396)  |
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| title: |
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Physical Activity and Insulin Sensitivity. The RISC Study. |
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| author(s): |
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Beverley Balkau ( ) 1, Leila Mhamdi1, Jean-Michel Oppert2, John Nolan3, Alain Golay4, Francesca Porcellati5, Markku Laakso6, Ele Ferrannini7 |
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| laboratory: |
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| short title : |
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Physical activity and insulin sensitivity |
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| abstract: |
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OBJECTIVE: Physical activity is a modifiable risk factor for type 2 diabetes, partly through its action on insulin sensitivity. We report the relation between insulin sensitivity and physical activity measured by accelerometry. RESEARCH DESIGN AND METHODS: This cross-sectional study is of 346 men and 455 women, aged 30 to 60 years, without cardiovascular disease and not treated by drugs for diabetes, hypertension, dyslipidaemia or obesity; they were recruited in 18 clinical centres from 13 European countries. Insulin sensitivity was measured by hyperinsulinaemic euglycaemic clamp. Physical activity was recorded by accelerometry for a median of six days. We studied the relationship of insulin sensitivity with total activity (number of counts/min), percent time spent sedentary, percent tine in light activity and activity intensity (whether the participant recorded some vigorous or some moderate activity). Results: In both men and women, total activity was associated with insulin sensitivity (P < 0.0001). Time spent sedentary, in light activity, and activity intensity were also associated with insulin sensitivity (P < 0.0004/0.01; 0.002/0.03; 0.02/0.004 respectively for men/women), but lost significance once adjusted for total activity. Adjustment for confounders, such as adiposity, attenuated the relations with total activity; there were no interactions with confounders. Even in the 25% most sedentary individuals, total activity was significantly associated with better insulin sensitivity (P < 0.0001) Conclusions: Accumulated daily physical activity is a major determinant of insulin sensitivity. Neither time spent sedentary, in light-activity, nor bouts of moderate or vigorous activity impacted on insulin sensitivity independently of total activity. |
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| subject: |
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Life Sciences/Health Care Sciences and Epidemiology
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| fulltext language: |
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English |
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| ISSN: |
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1939-327X |
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| publication format: |
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Article in peer-reviewed journal |
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| DOI: |
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10.2337/db07-1605 |
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| journal: |
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| Diabetes (Diabetes) |
| Publisher |
American Diabetes Association |
| ISSN |
0012-1797 (eISSN : 0012-1797) |
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| Audience: |
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international |
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| publication date: |
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2008-06-30 |
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| submission date: |
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2008-06-30 |
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| volume: |
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57 |
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| page, identifiant, ...: |
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2613-2618 |
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| contract, financing: |
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The RISC Study received the EU grant QLG1-CT-2001-01252. Additional finances have been provided by AstraZeneca (Sweden). The EGIR group is supported by Merck Santé, France. L Mhamdi was financed in part by a grant from La Fondation de France. |
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