Occupation and lymphoid malignancies: results from a French case-control study.

Laurent L. Orsi; Xavier X. Troussard; Alain A. Monnereau; Christian C. Berthou; Pierre P. Fenaux; Gerald G. Marit; Pierre P. Soubeyran; Françoise F. Huguet; Noel Milpied; Michel M. Leporrier; Denis Hemon; Jacqueline Clavel

inserm-00239464, version 1

Occupation and lymphoid malignancies: results from a French case-control study.
Orsi L. L., Troussard X. X., Monnereau A. A., Berthou C. C., Fenaux P. P., Marit G. G., Soubeyran P. P., Huguet F. F., Milpied N., Leporrier M. M. et al
Journal of Occupational & Environmental Medicine 49, 12 (2007) 1339-50 - http://www.hal.inserm.fr/inserm-00239464

PMID: identifier of
Pubmed reference:

(18231081)

title:

Occupation and lymphoid malignancies: results from a French case-control study.

author(s):

Laurent Orsi (

) ¹, Xavier Troussard², Alain Monnereau^{1, 3}, Christian Berthou⁴, Pierre Fenaux⁵, Gerald Marit⁶, Pierre Soubeyran³, Françoise Huguet⁷, Noel Milpied⁸, Michel Leporrier², Denis Hemon¹, Jacqueline Clavel¹

laboratory:

1:	Epidémiologie environnementale des cancers

http://ifr69.vjf.inserm.fr/u754/

INSERM : IFR69 – Université Paris XI - Paris Sud

16, Avenue Paul Vaillant-Couturier 94807 VILLEJUIF CEDEX

France

2:	Service d'Hématologie

CHU Caen – Hôpital côte de nacre

14000 Caen

France

3:	Institut Bergonié

http://www.bergonie.org/

Institut Bergonié - CRLCC Bordeaux

33076 Bordeaux Cedex

France

4:	Hôpital Morvan

CHU Brest

Brest

France

5:	Service d'hématologie clinique [Avicenne]

Assistance publique - Hôpitaux de Paris (AP-HP) – Hôpital Avicenne – Université Paris XIII - Paris Nord

125, rue de Stalingrad 93000 Bobigny

France

6:	Service des maladies du sang

Hôpital du Haut-Lévêque – CHU Bordeaux – Groupe Hospitalier Sud

Pessac

France

7:	Laboratoire d'Hématologie [Purpan]

Hôpital Purpan – CHU Toulouse – Université Paul Sabatier [UPS] - Toulouse III

Pôle Biologie, Place du Docteur Baylac - TSA 40031 - 31059 Toulouse cedex 9

France

8:	Service d'Hématologie Hôtel Dieu Nantes

Hôtel Dieu

Nantes

France

abstract:

OBJECTIVES: Investigating relationships between potential occupational risk factors and lymphoid malignancy (LM). METHODS: We conducted a multicenter hospital-based case-control study in France between 2000 and 2004, including 824 incident cases of non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL), multiple myeloma, and "lymphoproliferative syndrome" and 752 frequency-matched controls. Data were collected through face-to-face standardized and detailed interviews. RESULTS: Farming was significantly associated with NHL (odds ratio [OR] = 1.4 [1.0 to 2.0]) and, although not significantly, with lymphoproliferative syndrome and multiple myeloma. ORs were higher for longest durations of exposure. Self-declared exposure to pesticides was significantly associated with NHL (OR = 1.8 [1.2 to 2.7]) and HL (OR = 2.2 [1.0 to 4.7]). Neither solvent-related jobs nor self-reported exposure to solvents were related to LM. Systematic screening based on job titles did not evidence any other association. CONCLUSIONS: The results support the hypothesis that farming plays a role in most types of LM.

subject:

Life Sciences/Health Care Sciences and Epidemiology

fulltext language:

English

ISSN:

1076-2752

publication format:

Article in peer-reviewed journal

DOI:

10.1097/JOM.0b013e3181569a49

journal:

Journal of Occupational & Environmental Medicine

Audience:

international

publication date:

2007-12

volume:

issue:

page, identifiant, ...:

1339-50

keyword(s) of author:

occupational exposure – farming – risk – lymphoma – case-control study – epidemiology


inserm-00239464, version 1
http://www.hal.inserm.fr/inserm-00239464
oai:www.hal.inserm.fr:inserm-00239464
From: U754 Secretariat <>
Submitted on: Tuesday, 5 February 2008 18:14:51
Updated on: Wednesday, 6 February 2008 14:46:33