PMID: identifier of
Pubmed reference: |
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 (17344279)  |
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| title: |
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HLA-related genetic risk for coeliac disease. |
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| author(s): |
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Mathieu Bourgey1, Giuseppe Calcagno2, 3, Nada Tinto3, Daniela Gennarelli3, Patricia Margaritte-Jeannin1, Luigi Greco ( ) 4, Maria Giovanna Limongelli4, Oscar Esposito4, Caterina Marano4, Riccardo Troncone4, Antonella Spampanato3, Françoise Clerget-Darpoux1, Lucia Sacchetti3, For the FRM (Fondation de la Recherche Médicale ), ELFID (European Laboratory for the Investigation of Food-Induced Diseases), CEINGE, Regione Campania, • MIUR (Italian Ministero dell'Istruzione, dell'Università e della Ricerca) collaboration(s) |
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| laboratory: |
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| abstract: |
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BACKGROUND: Several studies have shown an elevated prevalence of coeliac disease (CD) in sibs of coeliac patients (risk 8-12%). Aim and method: This study seeks to evaluate the risk that sibs of children with CD will also develop CD. This cohort of 188 Italian families was composed of probands with CD, at least one sib, and both parents. CD status was determined and HLA-DQ genotyping performed for all family members. The study also used a data set of Italian triads (127 probands and both their parents) also genotyped for HLA-DQ. RESULTS: The overall risk that a sib of a CD patient will develop the disease is estimated at 10% in this sample. The risk estimate ranges from 0,1 to 29% when HLA-DQ information of the proband, parents and sib is considered. We found a negligible risk (lower than 1%) for 40% of the sibs of probands, a risk greater than 1% but less than 10% for 30%, and finally a high or very high risk (above 25%) in one third of families. CONCLUSION: These results make it possible to provide more accurate information to parents with child with CD about the real risk for another child. An antenatal estimate of the order of risk of CD is now possible. Specific follow-up can thus be offered for babies at high risk. |
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| subject: |
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Life Sciences/Genetics
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| fulltext language: |
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English |
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| ISSN: |
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0017-5749 |
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| publication format: |
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Article in peer-reviewed journal |
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| DOI: |
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10.1136/gut.2006.108530 |
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| journal: |
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| Gut (Gut) |
| Publisher |
BMJ Publishing Group |
| ISSN |
0017-5749 |
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| Audience: |
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not specified |
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| publication date: |
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2007-08 |
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| submission date: |
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2007-03-07 |
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| volume: |
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56 |
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| issue: |
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8 |
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| page, identifiant, ...: |
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1054-9 |
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| keyword(s) of author: |
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Coeliac Disease – HLA – first degree relatives – recurrence risk – family screening – DQ-typing |
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