PMID: identifier of
Pubmed reference: |
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 (16524739)  |
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| title: |
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Polymorphisms in chemokine and chemokine receptor genes and the development of coal workers' pneumoconiosis. |
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| author(s): |
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Rachel Nadif ( ) 1, Margaret Mintz2, Selma Rivas-Fuentes3, Anne Jedlicka2, Elise Lavergne3, Mathieu Rodero3, Francine Kauffmann1, Christophe Combadière3, Steven Kleeberger4 |
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| laboratory: |
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| abstract: |
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Chemokines and their receptors are key regulators of inflammation and may participate in the lung fibrotic process. Associations of polymorphisms in CCL5 (G-403A) and its receptor CCR5 (Delta32), CCL2 (A-2578G) and CCR2 (V64I), and CX3CR1 V249I and T280M with coal worker's pneumoconiosis (CWP) were investigated in 209 miners examined in 1990, 1994 and 1999. Coal dust exposure was assessed by job history and ambient measures. The main health outcome was lung computed tomography (CT) score in 1990. Internal coherence was assessed by studying CT score in 1994, 4-year change in CT score, and CWP prevalence in 1999. CCR5 Delta32 carriers had significantly higher CT score in 1990 and 1994 (2.15 vs. 1.28, p=0.01; 3.04 vs. 1.80, p=0.04). The CX3CR1 I249 allele was significantly associated with lower 1990 CT score and lower progression in 4-year change in CT score in CCR5 Delta32 carriers only (p for interaction=0.03 and 0.02). CX3CR1 V249I was associated with lower 1999 CWP prevalence (16.7%, 13.2%, 0.0% for VV, VI and II); the effect was most evident in miners with high dust exposure (31.6%, 21.7%, 0.0%). Our findings indicate that chemokine receptors CCR5 and CX3CR1 may be involved in the development of pneumoconiosis. |
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| subject: |
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Life Sciences/Health Care Sciences and Epidemiology
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| fulltext language: |
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English |
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| ISSN: |
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1043-4666 |
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| publication format: |
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Article in peer-reviewed journal |
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| DOI: |
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10.1016/j.cyto.2006.01.001 |
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| journal: |
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| Cytokine (Cytokine) |
| Publisher |
Elsevier |
| ISSN |
1043-4666 (eISSN : 1096-0023) |
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| publication date: |
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2006-02-07 |
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| volume: |
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33 |
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| issue: |
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3 |
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| page, identifiant, ...: |
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171-8 |
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| MeSH Descriptor(s): |
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Adult – Chemokine CCL2 – Chemokines – CC – Coal Mining – Gene Frequency – Genotype – Humans – Membrane Proteins – Middle Aged – Phenotype – Pneumoconiosis – Polymorphism – Genetic – Single Nucleotide – Prevalence – Receptors – CCR5 – Ch |
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| contract, financing: |
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Action Thématique Concertée Environnement&Santé 2003 ATC-ASE04080LSA |
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