PMID: identifier of
Pubmed reference: |
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 (17077393)  |
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| title: |
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Advances in medical technology and creation of disparities: the case of Down syndrome. |
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| author(s): |
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Babak Khoshnood1, Catherine De Vigan1, Véronique Vodovar1, Gérard Bréart1, François Goffinet1, Béatrice Blondel1 |
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| laboratory: |
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| abstract: |
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OBJECTIVES: We assessed socioeconomic differences in probabilities of prenatal diagnoses of Down syndrome and continuation of pregnancies after such diagnoses, along with the effects of these differences on disparities in live-birth prevalences of Down syndrome. METHODS: Using population-based data derived from 1433 cases of Down syndrome and 3731 control births, we assessed age-adjusted effects of maternal occupation and geographic origin on prenatal diagnoses, as well as overall and live-birth odds, of Down syndrome. RESULTS: Maternal occupation and geographic origin had significant effects on the probability of a prenatal diagnosis of Down syndrome and on continuation of pregnancy after such a diagnosis. Women in lower-status occupational categories had higher odds of delivering a live-born infant with Down syndrome. In comparison with women in the highest-status occupational category, the age-adjusted odds ratio for a Down syndrome live birth among women without an occupation was 2.4 (95% confidence interval [CI] = 1.7, 3.3). By contrast, there were no disparities in age-adjusted overall likelihood of Down syndrome. CONCLUSIONS: Socioeconomic differences in use of prenatal testing have created disparities in the live-birth prevalence of Down syndrome. Overall Down syndrome risk does not vary according to socioeconomic status. |
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| subject: |
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Life Sciences/Health Care Sciences and Epidemiology
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| fulltext language: |
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English |
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| ISSN: |
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1541-0048 |
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| publication format: |
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Article in peer-reviewed journal |
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| DOI: |
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10.2105/AJPH.2005.069377 |
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| journal: |
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Am J Public Health |
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| Audience: |
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international |
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| publication date: |
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2006-12 |
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| submission date: |
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2006-10-31 |
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| volume: |
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96 |
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| issue: |
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12 |
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| page, identifiant, ...: |
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2139-44 |
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