PMID: identifier of
Pubmed reference: |
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 (15880532) |
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| title: |
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Dietary calcium, phosphorus, vitamin D, dairy products and the risk of colorectal adenoma and cancer among French women of the E3N-EPIC prospective study. |
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| author(s): |
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Emmanuelle Kesse1, Marie-Christine Boutron-Ruault1, 2, Teresa Norat3, Elio Riboli3, Françoise Clavel-Chapelon1, For the E3N Group collaboration(s) |
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| laboratory: |
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| abstract: |
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A protective effect of calcium and/or dairy products on colorectal cancer has been reported in epidemiological studies but the findings are considered inconsistent. In particular, it is unclear whether they act at a particular step of the adenoma-carcinoma sequence. To investigate the effect of dairy product consumption and dietary calcium, vitamin D and phosphorus intake on the adenoma-carcinoma sequence in the French E3N-EPIC prospective study. The population for the study of risk factors for adenomas was composed of 516 adenoma cases, including 175 high-risk adenomas, and of 4,804 polyp-free subjects confirmed by colonoscopy. The population for the colorectal cancer study was composed of 172 cases and 67,312 cancer-free subjects. Diet was assessed using a self-administered questionnaire completed at baseline. There was a trend of decreasing risk of both adenoma (ptrend=0.04) and cancer (ptrend=0.08) with increasing calcium intake, with RRs for adenoma and cancer of 0.80 (IC 95%=0.62-1.03) and 0.72 (95% CI=0.47-1.10), respectively, in the fourth quartile compared to the first. A protective effect of dairy products on adenoma (RRQ4 vs. Q1=0.80, 95% CI=0.62-1.05, ptrend=0.04) was observed and of milk consumption on colorectal cancer (RRQ4vs. Q1=0.54, 95% CI=0.33-0.89, ptrend=0.09), although the latter did not reach significance. Phosphorus intake also decreased the risk of adenoma (RRQ4 vs. Q1=0.70, 95% CI=0.54-0.90, ptrend=0.005). No vitamin D effect was identified. Our data support the hypothesis that calcium, dairy products and phosphorus exert a protective effect at certain steps of the adenoma-carcinoma sequence. |
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| subject: |
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| fulltext language: |
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English |
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| ISSN: |
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0020-7136 |
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| publication format: |
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Article in peer-reviewed journal |
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| DOI: |
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10.1002/ijc.21148 |
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| journal: |
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Int J Cancer |
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| Audience: |
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not specified |
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| publication date: |
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2005-10-20 |
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| volume: |
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117 |
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| issue: |
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1 |
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| page, identifiant, ...: |
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137-44 |
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| MeSH Descriptor(s): |
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Adenoma – Aged – Calcium – Dietary – Case-Control Studies – Colorectal Neoplasms – Dairy Products – Female – France – Humans – Middle Aged – Phosphorus – Prospective Studies – Research Support – Non-U.S. Gov't – Risk Factors – Vitamin D |
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