| Subject: |
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Life Sciences/Human health and pathology
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| PMID (PubMed ID): |
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 (16409454) |
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| Title: |
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Indicators of lifetime endogenous estrogen exposure and risk of venous thromboembolism. |
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| Author(s): |
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T. Simon1, 2, M. Beau Yon De Jonage-Canonico1, Emmanuel Oger3, Denis Wahl4, Jacqueline Conard5, Guy Meyer6, Joseph Emmerich7, Marie-Thérèse Barrellier8, A. Guiraud1, Pierre-Yves Scarabin ( ) 1, |
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| Laboratory: |
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| Abstract: |
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BACKGROUND: Lifetime estrogen exposure has been related to breast cancer risk, osteoporosis, and cardiovascular disease but data on venous thromboembolism (VTE) risk are limited. METHODS: Data from a hospital-based case-control study among 608 postmenopausal women (191 with a first episode of idiopathic VTE and 417 age-matched controls) were used to determine whether estrogen exposure, as assessed by age at menopause [classified as early (< or = 45 years), normal (46-54 years) and late menopause (> or = 55 years)] and parity, was associated with the risk of VTE. RESULTS: After adjustment for potential confounding variables, the risk of VTE was increased with each year's delay in the menopause [odds ratio (OR) = 1.06, 95% confidence interval (CI) = 1.02-1.10, P < 0.0075]. When compared with women with normal menopause used as a reference, the adjusted OR for VTE was 0.59 (95% CI = 0.36-0.97) and 2.53 (95% CI = 1.28-4.99) for women with early menopause and late menopause, respectively (P = 0.001). Adjusted OR for VTE was also higher for women with more than two children when compared with those with less than or equal to two children (1.56, 95% CI = 1.03-2.34, P = 0.03). The lowest risk of VTE was observed in women with early menopause and lower parity (adjusted OR = 0.60, 95% CI = 0.30-1.24), the highest risk was among women with late menopause who have had more than two children (adjusted OR = 3.41, 95% CI = 1.46-9.25). CONCLUSION: These results show that the longer exposure to endogenous estrogen is associated with an increased VTE risk. |
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| Fulltext language: |
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English |
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| Publication type: |
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Article in peer-reviewed journal |
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| DOI: |
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10.1111/j.1538-7836.2005.01693.x |
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| Journal: |
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| Journal of Thrombosis and Haemostasis (J Thromb Haemost) |
| Publisher |
Wiley-Blackwell |
| ISSN |
1538-7933 (eISSN : 1538-7836) |
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| Audience: |
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international |
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| Publication date: |
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2006-01 |
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| Volume: |
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4 |
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| Issue: |
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1 |
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| Page, identifiant, ...: |
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71-6 |
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| MeSH Classification: |
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Age Factors – Aged – Case-Control Studies – Estrogens – Female – Humans – Menopause – Middle Aged – Odds Ratio – Parity – Pregnancy – Pulmonary Embolism – Risk – Thromboembolism – Venous Thrombosis |
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