| Subject: |
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Life Sciences/Ecology, environment/Health
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| PMID (PubMed ID): |
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 (21900077)  |
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| Title: |
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Exposure to Phthalates and Phenols during Pregnancy and Offspring Size at Birth. |
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| Author(s): |
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Claire Philippat1, 2, Marion Mortamais1, 3, Cécile Chevrier4, Claire Petit4, Antonia M. Calafat5, Xiaoyun Ye5, Manori J. Silva5, Christian Brambilla1, 2, Isabelle Pin2, 6, Marie-Aline Charles7, 8, Sylvaine Cordier4, Rémy Slama1, 2 |
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| Laboratory: |
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| Research team: |
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INSERM U823, équipe 2 (Bases Moléculaires de la Progression des Cancers du Poumon)
INSERM U823, équipe 12 (Epidémiologie Environnementale appliquée à la Reproduction et la Santé Respiratoire) |
| Abstract: |
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Background: Data concerning the effects of prenatal exposures to phthalates and phenols on fetal growth are limited in humans. Previous findings suggest possible effects of some phenols on male birth weight.Objective: Our aim was to assess the relationships between prenatal exposures to phthalates and phenols and fetal growth among male newborns.Methods: We conducted a case-control study on male malformations of the genitalia nested in two French mother-child cohorts with recruitment between 2002 and 2006. We measured, in maternal urinary samples collected between 6 and 30 gestational weeks, the concentrations (micrograms per liter) of 9 phenol (n = 191 pregnant women) and 11 phthalate metabolites (n = 287). Weight, length, and head circumference at birth were collected from maternity records. Statistical analyses were corrected for the oversampling of malformation cases.Results: Adjusted birth weight decreased by 77 g [95% confidence interval (CI): -129, -25] and by 49 g (95% CI: -86, -13) in association with a 1-unit increase in ln-transformed 2,4-dichlorophenol (DCP) and 2,5-DCP urinary concentrations, respectively. Benzophenone-3 (BP3) ln-transformed concentrations were positively associated with weight (26 g; 95% CI: -2, 54) and head circumference at birth (0.1 cm; 95% CI: 0.0, 0.2). Head circumference increased by 0.3 cm (95% CI: 0.0, 0.7) in association with a 1-unit increase in ln-transformed BPA concentration. For phthalate metabolites there was no evidence of monotonic associations with birth weight.Conclusions: Consistent with findings of a previous study, we observed evidence of an inverse association of 2,5-DCP and a positive association of BP3 with male birth weight. |
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| Fulltext language: |
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English |
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| Publication type: |
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Article in peer-reviewed journal |
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| DOI: |
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10.1289/ehp.1103634 |
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| Journal: |
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| Audience: |
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international |
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| Publication date: |
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2012-03 |
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| Submission date: |
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2011-09-07 |
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| Volume: |
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120 |
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| Issue: |
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3 |
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| Page, identifiant, ...: |
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464-70 |
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| Keyword(s): |
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birth outcomes – fetal growth – phenols – phthalates – pregnancy exposure – urinary biomarkers |
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| Contract, financing: |
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French Agency for Food, Environmental and Occupational Health and Safety (ANSES); la Fondation pour la Recherche Médicale; INSERM; Institut de Recherche en Santé Publique; Nestlé; French Ministry of Health; Agence Nationale de la Recherche (ANR); Université Paris-Sud; Institut de veille sanitaire (InVS); ANSES; Mutuelle Générale de l'Education Nationale; Regional Council of Brittany |
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