PMID: identifiant
de la référence Pubmed : |
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 (22915175)  |
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| titre : |
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Obesity phenotypes in midlife and cognition in early old age: The Whitehall II cohort study. |
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| auteur(s) : |
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Archana Singh-Manoux ( ) 1, 2, 3, Sébastien Czernichow1, 4, Alexis Elbaz5, Aline Dugravot1, Séverine Sabia2, Gareth Hagger-Johnson2, Sara Kaffashian1, Marie Zins1, Eric Brunner2, Hermann Nabi1, Mika Kivimäki2 |
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| laboratoire : |
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| résumé : |
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OBJECTIVE: To examine the association of body mass index (BMI) and metabolic status with cognitive function and decline. METHODS: A total of 6,401 adults (71.2% men), aged 39-63 years in 1991-1993, provided data on BMI (normal weight 18.5-24.9 kg/m(2), overweight 25-29.9 kg/m(2); and obese ≥30 kg/m(2)) and metabolic status (abnormality defined as 2 or more of 1) triglycerides ≥1.69 mmol/L or lipid-lowering drugs, 2) systolic blood pressure ≥130 mm Hg, diastolic blood pressure ≥85 mm Hg, or antihypertensive drugs, 3) glucose ≥5.6 mmol/L or medications for diabetes, and 4) high-density lipoprotein cholesterol <1.04 mmol/L for men and <1.29 mmol/L for women). Four cognitive tests (memory, reasoning, semantic, and phonemic fluency) were administered in 1997-1999, 2002-2004, and 2007-2009, standardized to z scores, and averaged to yield a global score. RESULTS: Of the participants, 31.0% had metabolic abnormalities, 52.7% were normal weight, 38.2% were overweight, and 9.1% were obese. Among the obese, the global cognitive score at baseline (p = 0.82) and decline (p = 0.19) over 10 years was similar in the metabolically normal and abnormal groups. In the metabolically normal group, the 10-year decline in the global cognitive score was similar (p for trend = 0.36) in the normal weight (-0.40; 95% confidence interval [CI] -0.42 to -0.38), overweight (-0.42; 95% CI -0.45 to -0.39), and obese (-0.42; 95% CI -0.50 to -0.34) groups. However, in the metabolically abnormal group, the decline on the global score was faster among obese (-0.49; 95% CI -0.55 to -0.42) than among normal weight individuals (-0.42; 95% CI -0.50 to -0.34), (p = 0.03). CONCLUSIONS: In these analyses the fastest cognitive decline was observed in those with both obesity and metabolic abnormality. |
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| domaine : |
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Sciences du Vivant/Santé publique et épidémiologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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0028-3878 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1212/WNL.0b013e3182661f63 |
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| journal : |
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| Neurology Journal (Neurology) |
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American Academy of Neurology (AAN) |
| ISSN |
0028-3878 (eISSN : 1526-632X) |
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| Audience : |
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internationale |
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| date de publication : |
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21/08/2012 |
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| volume : |
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79 |
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| numéro : |
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8 |
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| page, identifiant, ... : |
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755-62 |
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| contrat, financement : |
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Study Funding: NIH (R01AG013196; R01AG034454, R01HL036310), Academy of Finland, the BUPA Foundation, UK; Medical Research Council (G0902037), UK. |
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