PMID: identifiant
de la référence Pubmed : |
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 (22416008) |
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| titre : |
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Estimation of the frequency of involuntary infertility on a nation-wide basis |
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| auteur(s) : |
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Rémy Slama ( ) 1, Oluf Kristian Højbjerg Hansen2, Béatrice Ducot3, Aline Bohet3, Ditte Sorensen2, Lise Giorgis Allemand1, Marinus Eijkemans4, Lyliane Rosetta5, Jean-Christophe Thalabard6, Niels Keiding2, Jean BOUYER3 |
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| laboratoire : |
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| Équipe de recherche : |
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INSERM U823, équipe 12 (Epidémiologie Environnementale appliquée à la Reproduction et la Santé Respiratoire) |
| titre abrégé : |
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A nation-wide survey of couple fecundity |
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| résumé : |
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BACKGROUNDAssessing couple fecundity on a nation-wide basis without excluding couples who eventually remain infertile is challenging. Our aim was to describe couple fecundity (in terms of frequency of involuntary infertility) among the general population living in France.METHODSWe used a current-duration design. A random sample of 64 262 households was selected in 2007-2008, allowing us to identify 15 810 women aged 18-44 years. Eligible women (n= 1089) were those having regular sexual intercourse with a male partner, not using any method of contraception and not having delivered in the previous 3 months. These women reported information on the current duration of unprotected intercourse (CDUI, the time elapsed between the start of the period of unprotected intercourse and the time of inclusion in the study). The CDUI distribution was used to estimate the frequency of involuntary infertility, using a newly developed statistical technique that does not require couples to be followed up until the end of the period of unprotected intercourse.RESULTSCDUI was defined for 867 women. An estimated 46% of couples had no detected pregnancy conceived during the first 6 months of unprotected intercourse [95% confidence interval (CI), 36-56%]. The proportions of couples with no detected pregnancy within 12 and 24 months were 24% (19-30%) and 11% (8-14%), respectively.CONCLUSIONSThese results constitute one of the few descriptions of the fecundity of a nation-wide representative sample of couples from the general population, not limited to couples who eventually conceived or to those resorting to medical help. |
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| domaine : |
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Sciences du Vivant/Santé publique et épidémiologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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0268-1161 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1093/humrep/des070 |
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| journal : |
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| Human Reproduction (Hum Reprod) |
| Publisher |
Oxford University Press (OUP): Policy B1 |
| ISSN |
0268-1161 (eISSN : 1460-2350) |
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| Audience : |
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internationale |
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| date de publication : |
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12/03/2012 |
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date de publication
électronique : |
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12/03/2012 |
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| page, identifiant, ... : |
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epub ahead of print |
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| mots-clés auteur : |
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Fecundability – Fecundity – Infertility – Involuntary infertility – Pregnancy |
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| contrat, financement : |
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The study was funded by grants from ANR (French Agency for Research, SEST call on 15 Environmental and Occupational Health), ANSES (French Agency for Food, environmental 16 and Occupational Health Safety, EST call on Environmental and Occupational Health), InVS 17 (French Institute for Public Health Surveillance). The team of Environmental Epidemiology is 18 funded by an AVENIR grant from Inserm (2007). |
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