PMID: identifiant
de la référence Pubmed : |
 |
 (21730862) |
|
| titre : |
|
Short-term impact of ambient air pollution and air temperature on blood pressure among pregnant women. |
|
| auteur(s) : |
|
Regina Hampel1, Johanna Lepeule2, Alexandra Schneider1, Sébastien Bottagisi2, Marie-Aline Charles3, Pierre Ducimetière4, Annette Peters1, Rémy Slama2 |
|
| laboratoire : |
|
|
|
| Équipe de recherche : |
|
INSERM U823, équipe 12 (Epidémiologie Environnementale appliquée à la Reproduction et la Santé Respiratoire) |
| résumé : |
|
BACKGROUND: Epidemiologic studies have reported inconsistent findings for the association between air pollution levels and blood pressure (BP), which has been studied mainly in elderly subjects. Short-term air pollution effects on BP have not been investigated in pregnant women, who may constitute a vulnerable population. METHODS: Between 2002 and 2006, 1500 pregnant women from a mother-child cohort study conducted in Nancy and Poitiers, France, underwent 11,220 repeated BP measurements (average, 7.5 measurements/woman). Nitrogen dioxide (NO₂), particulate matter with an aerodynamic diameter below 10 μm (PM₁₀), and meteorologic variables were measured on an hourly basis at permanent monitoring sites. We studied changes of BP in relation to short-term variations of air pollution and temperature with mixed models adjusted for meteorologic and personal characteristics. RESULTS: A 10°C decrease in temperature led to an increase in systolic BP of 0.5% (95% confidence interval = 0.1% to 1.0%). Elevated NO₂-levels 1 day, 5 days and averaged over 7 days before the BP measurement were associated with reduced systolic BP. The strongest decrease was observed for the 7-day NO₂ average (-0.4% [-0.7% to -0.2%] change for an 11 μg/m³ increase in NO₂). PM₁₀ effects on systolic BP differed according to pregnancy trimester: PM₁₀ concentration was associated with systolic BP increases during the first trimester and systolic BP decreases later in pregnancy. CONCLUSIONS: We observed short-term associations of air pollution and of temperature with BP in pregnant women. Whether such changes in BP have clinical implications remains to be investigated. |
|
| domaine : |
|
Sciences du Vivant/Santé publique et épidémiologie
|
|
langue du texte
intégral : |
|
Anglais |
|
| ISSN : |
|
1531-5487 |
|
|
| type de publication : |
|
Articles dans des revues avec comité de lecture |
|
| DOI : |
|
10.1097/EDE.0b013e318226e8d6 |
|
| journal : |
|
| Epidemiology (Epidemiology) |
| Publisher |
Lippincott, Williams & Wilkins |
| ISSN |
1044-3983 |
|
|
| Audience : |
|
internationale |
|
| date de publication : |
|
09/2011 |
|
date de publication
électronique : |
|
01/07/2011 |
|
| volume : |
|
22 |
|
| numéro : |
|
5 |
|
| page, identifiant, ... : |
|
671-9 |
|
|
| contrat, financement : |
|
Supported by a grant from ANSES (French Agency for food, environment and occupation health safety, call EST-Environment Santé Travail, Eden- Air Plus project). The Eden cohort is funded by the Foundation for Medical Research (FRM), Inserm, IReSP, Nestlé, French Ministry of Health, National Research Agency (ANR), Univ. Paris-Sud, Institute of Health Monitoring (InVS), ANSES, MGEN, AFSSA. The team of Environmental Epidemiology (Inserm U823) is supported by an AVENIR grant from Inserm. |
|
