PMID: identifier of
Pubmed reference: |
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 (20185739)  |
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| title: |
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High baseline insulin levels associated with 6-year incident observed sleep apnea. |
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| author(s): |
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Beverley Balkau ( ) 1, Sylviane Vol2, Sandrine Loko1, Tiana Andriamboavonjy1, Olivier Lantieri2, Gaelle Gusto2, Nicole Meslier3, Jean-Louis Racineux3, Jean Tichet2, The D.E.S.I.R Study Group2 |
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| laboratory: |
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| short title : |
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Hyperinsulinaemia precedes incident observed sleep apnea |
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| abstract: |
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OBJECTIVE: Obstructive sleep apnea is common in patients with type 2 diabetes, and its association with insulin and insulin resistance has been examined in cross-sectional studies. We evaluate risk factors for incident observed sleep apnea in a general population not selected for sleep disturbances. RESEARCH DESIGN AND METHODS: A total of 1,780 men and 1,785 women, aged 33 to 68 years, from the cohort Data from an Epidemiologic Study on the Insulin Resistance Syndrome (D.E.S.I.R.) responded to the question, "Has someone said to you that you stop breathing during your sleep?" at baseline and 6 years. Anthropometric, clinical, and biological factors were recorded at both time points. RESULTS: At baseline, 14% of men and 7% of women reported having observed sleep apnea (positive response to question); 6-year incidences were 14 and 6%, respectively. Age, anthropometric parameters, blood pressure, and sleep characteristics were all associated with prevalent, observed apnea episodes, in both sexes. Baseline waist circumference was the strongest predictor of incident apnea: standardized odds ratio (OR), adjusted for age and sex, 1.34 (95% CI 1.19-1.52). After adjustment for age, sex, and waist circumference, the standardized ORs for incident observed apnea were identical for fasting insulin and the homeostasis model assessment of insulin resistance: 1.31 (1.13-1.51) and 1.24 (1.09-1.41) for triglycerides and 1.52 (1.12-2.05) for smoking. Observed apnea at baseline was not associated with changes in anthropometric or biological parameters over the 6-year follow-up. CONCLUSIONS: The most important baseline risk factor for incident apnea was adiposity. After accounting for adiposity, other risk factors were high insulin, insulin resistance, high triglycerides, and smoking, factors amenable to lifestyle intervention. |
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| subject: |
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Life Sciences/Health Care Sciences and Epidemiology
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| fulltext language: |
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English |
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| ISSN: |
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1935-5548 |
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| publication format: |
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Article in peer-reviewed journal |
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| DOI: |
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10.2337/dc09-1901 |
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| journal: |
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| Diabetes Care (Diabetes Care) |
| Publisher |
American Diabetes Association |
| ISSN |
0149-5992 (eISSN : 0149-5992) |
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| Audience: |
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international |
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| publication date: |
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2010-05 |
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| submission date: |
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2010-02-25 |
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| volume: |
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33 |
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| issue: |
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5 |
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| page, identifiant, ...: |
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1044-9 |
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| keyword(s) of author: |
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abdominal obesity – apnea – epidemiology – hyperinsulinaemia – insulin resistance – obesity – prospective – sleep |
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| comment: |
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Abstract: 250 words Text: 2938 words, 17 pages One on-line appendix 3 tables 22 references |
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| contract, financing: |
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The D.E.S.I.R. study has been supported by INSERM contracts with CNAMTS, Lilly, Novartis Pharma and Sanofi-Aventis; by INSERM (Réseaux en Santé Publique, Interactions entre les déterminants de la santé, Cohortes Santé TGIR 2008), the Association Diabète Risque Vasculaire, the Fédération Française de Cardiologie, La Fondation de France, ALFEDIAM, ONIVINS, Ardix Medical, Bayer Diagnostics, Becton Dickinson, Cardionics, Merck Santé, Novo Nordisk, Pierre Fabre, Roche, Topcon |
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