PMID: identifier of
Pubmed reference: |
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 (21730862) |
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| title: |
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Short-term impact of ambient air pollution and air temperature on blood pressure among pregnant women. |
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| author(s): |
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Regina Hampel1, Johanna Lepeule2, Alexandra Schneider1, Sébastien Bottagisi2, Marie-Aline Charles3, Pierre Ducimetière4, Annette Peters1, Rémy Slama2 |
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| laboratory: |
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| Research team: |
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INSERM U823, équipe 12 (Epidémiologie Environnementale appliquée à la Reproduction et la Santé Respiratoire) |
| abstract: |
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BACKGROUND: Epidemiologic studies have reported inconsistent findings for the association between air pollution levels and blood pressure (BP), which has been studied mainly in elderly subjects. Short-term air pollution effects on BP have not been investigated in pregnant women, who may constitute a vulnerable population. METHODS: Between 2002 and 2006, 1500 pregnant women from a mother-child cohort study conducted in Nancy and Poitiers, France, underwent 11,220 repeated BP measurements (average, 7.5 measurements/woman). Nitrogen dioxide (NO₂), particulate matter with an aerodynamic diameter below 10 μm (PM₁₀), and meteorologic variables were measured on an hourly basis at permanent monitoring sites. We studied changes of BP in relation to short-term variations of air pollution and temperature with mixed models adjusted for meteorologic and personal characteristics. RESULTS: A 10°C decrease in temperature led to an increase in systolic BP of 0.5% (95% confidence interval = 0.1% to 1.0%). Elevated NO₂-levels 1 day, 5 days and averaged over 7 days before the BP measurement were associated with reduced systolic BP. The strongest decrease was observed for the 7-day NO₂ average (-0.4% [-0.7% to -0.2%] change for an 11 μg/m³ increase in NO₂). PM₁₀ effects on systolic BP differed according to pregnancy trimester: PM₁₀ concentration was associated with systolic BP increases during the first trimester and systolic BP decreases later in pregnancy. CONCLUSIONS: We observed short-term associations of air pollution and of temperature with BP in pregnant women. Whether such changes in BP have clinical implications remains to be investigated. |
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| subject: |
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Life Sciences/Health Care Sciences and Epidemiology
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| fulltext language: |
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English |
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| ISSN: |
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1531-5487 |
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| publication format: |
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Article in peer-reviewed journal |
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| DOI: |
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10.1097/EDE.0b013e318226e8d6 |
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| journal: |
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| Epidemiology (Epidemiology) |
| Publisher |
Lippincott, Williams & Wilkins |
| ISSN |
1044-3983 |
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| Audience: |
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international |
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| publication date: |
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2011-09 |
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| submission date: |
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2011-07-01 |
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| volume: |
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22 |
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| issue: |
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5 |
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| page, identifiant, ...: |
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671-9 |
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| contract, financing: |
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Supported by a grant from ANSES (French Agency for food, environment and occupation health safety, call EST-Environment Santé Travail, Eden- Air Plus project). The Eden cohort is funded by the Foundation for Medical Research (FRM), Inserm, IReSP, Nestlé, French Ministry of Health, National Research Agency (ANR), Univ. Paris-Sud, Institute of Health Monitoring (InVS), ANSES, MGEN, AFSSA. The team of Environmental Epidemiology (Inserm U823) is supported by an AVENIR grant from Inserm. |
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