The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3), JAMA, vol.315, issue.8, pp.801-810, 2016. ,
DOI : 10.1001/jama.2016.0287
Assessment of Global Incidence and Mortality of Hospital-treated 15. Hamitouche, N. et al. Population Pharmacokinetic-Pharmacodynamic Model of Oral Fludrocortisone and Intravenous Hydrocortisone in Healthy Volunteers, AAPS J, vol.19, pp.727-735, 2017. ,
Basic Concepts in Population Modeling, Simulation, and Model-Based Drug Development: Part 3???Introduction to Pharmacodynamic Modeling Methods, CPT: Pharmacometrics & Systems Pharmacology, vol.4, issue.1 ,
DOI : 10.1016/S0009-9236(97)90160-0
, CPT Pharmacomet. Syst. Pharmacol, vol.3, p.88, 2014.
Population modelling in drug development ,
, Res, vol.8, pp.183-193, 1999.
The endothelial mineralocorticoid receptor regulates vasoconstrictor tone and blood pressure, The FASEB Journal, vol.24, issue.7, pp.2454-2463, 2010. ,
DOI : 10.1161/HYPERTENSIONAHA.107.088955
9-alpha-Fluorocortisol-induced hypertension: a review, J ,
, Hypertens, vol.4, pp.133-139, 1986.
DIFFERENTIAL BLOOD PRESSURE AND METABOLIC EFFECTS OF 9?-FLUOROCORTISOL IN MAN, Clinical and Experimental Pharmacology and Physiology, vol.39, issue.3, pp.351-354, 1983. ,
DOI : 10.1016/0026-0495(79)90201-4
Corticosteroids for treating sepsis, Cochrane Database of Systematic Reviews, vol.301, issue.12, p.2243, 2015. ,
DOI : 10.1002/14651858.CD002243.pub3
URL : https://hal.archives-ouvertes.fr/hal-01274237
Safety and Efficacy of Corticosteroids for the Treatment of Septic Shock: A Systematic Review and Meta???Analysis, Clinical Infectious Diseases, vol.49, issue.1, pp.93-101, 2009. ,
DOI : 10.1086/599343
The effects of steroids during sepsis depend on dose and severity of illness: an updated meta-analysis, Clinical Microbiology and Infection, vol.15, issue.4, pp.308-318, 2009. ,
DOI : 10.1111/j.1469-0691.2009.02752.x
Glucocorticosteroids for sepsis: systematic review with meta-analysis and trial sequential analysis, Intensive Care Medicine, vol.16, issue.3, pp.1220-1234, 2015. ,
DOI : 10.1186/cc1498
Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model, Nature Reviews Drug Discovery, vol.3, issue.1, pp.27-41, 2004. ,
DOI : 10.1038/nrd1283
Antiinflammatory Action of Glucocorticoids ??? New Mechanisms for Old Drugs, New England Journal of Medicine, vol.353, issue.16, pp.1711-1723, 2005. ,
DOI : 10.1056/NEJMra050541
The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology, Nuclear Receptor Signaling, vol.4, 2007. ,
DOI : 10.1621/nrs.05012
URL : https://hal.archives-ouvertes.fr/inserm-00193515
Mineralocorticoid effects due to cortisol inactivation overload explain the beneficial use of hydrocortisone in septic shock, Medical Hypotheses, vol.70, issue.1, pp.56-60, 2008. ,
DOI : 10.1016/j.mehy.2007.04.031
Principles and Practice of Endocrinology and Metabolism, 2001. ,
Efficacy of selective mineralocorticoid and glucocorticoid agonists in canine septic shock, Critical Care Medicine, vol.40, issue.1, 2012. ,
DOI : 10.1097/CCM.0b013e31822efa14
URL : http://europepmc.org/articles/pmc3242885?pdf=render
Clinical effects of adding fludrocortisone to a hydrocortisone-based shock protocol in hypotensive critically ill children, Intensive Care Medicine, vol.78, issue.3, pp.518-524, 2011. ,
DOI : 10.2223/JPED.912
Aldosterone and Vascular Mineralocorticoid Receptors in Murine Endotoxic and Human Septic Shock*, Critical Care Medicine, vol.45, issue.9, 2017. ,
DOI : 10.1097/CCM.0000000000002462
INHIBITION OF NF-??B ACTIVITY PREVENTS DOWNREGULATION OF ??1-ADRENERGIC RECEPTORS AND CIRCULATORY FAILURE DURING CLP-INDUCED SEPSIS, Shock, vol.32, issue.3, pp.239-246, 2009. ,
DOI : 10.1097/SHK.0b013e3181994752
Cytokines down-regulate ??1-adrenergic receptor expression during endotoxemia, Critical Care Medicine, vol.31, issue.2, pp.566-571, 2003. ,
DOI : 10.1097/01.CCM.0000048621.36569.69
Measurement of Strain and Strain Rate by Echocardiography, Journal of the American College of Cardiology, vol.47, issue.7, pp.1313-1327, 2006. ,
DOI : 10.1016/j.jacc.2005.11.063
Recommendations for the evaluation of left ventricular diastolic function by echocardiography, Eur. J. Echocardiogr. J. Work ,
, Cardiol, vol.10, pp.165-193, 2009.
A survey of population analysis methods and software for complex pharmacokinetic and pharmacodynamic models with examples, The AAPS Journal, vol.9, issue.1, p.60, 2007. ,
DOI : 10.1208/aapsj0901007
The possible effects of the aggregation of the molecules of hemoglobin on its dissociation curves, J. Physiol, vol.40, p.iv?vii, 1910. ,
Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: The npde add-on package for R, Computer Methods and Programs in Biomedicine, vol.90, issue.2, pp.154-166, 2008. ,
DOI : 10.1016/j.cmpb.2007.12.002
URL : https://hal.archives-ouvertes.fr/inserm-00274332
, REFERENCES, vol.1
Fludrocortisone and Hydrocortisone, Alone or in Combination, on In Vivo Hemodynamics and In Vitro Vascular Reactivity in Normal and Endotoxemic Rats, Journal of Cardiovascular Pharmacology, vol.63, issue.6, 2014. ,
DOI : 10.1097/FJC.0000000000000072
URL : https://hal.archives-ouvertes.fr/hal-01147027
,
Aldosterone and Vascular Mineralocorticoid Receptors in Murine Endotoxic and Human Septic Shock Crit Care Med, 2017. ,
, Pharmacokinetics of oral fludrocortisone in septic shock, Br J Clin Pharmacol, vol.82, issue.6, pp.1509-1525, 2016.
Gluco- and mineralocorticoid biological effects of a 7-day treatment with low doses of hydrocortisone and fludrocortisone in septic shock, Intensive Care Medicine, vol.15, issue.8, pp.1306-1320, 2012. ,
DOI : 10.1186/cc10262
Effect of Treatment With Low Doses of Hydrocortisone and Fludrocortisone on Mortality in Patients With Septic Shock, JAMA, vol.288, issue.7, pp.862-71, 2002. ,
DOI : 10.1001/jama.288.7.862
Population Pharmacokinetic-Pharmacodynamic Model of Oral Fludrocortisone and Intravenous Hydrocortisone in Healthy Volunteers, The AAPS Journal, vol.19, issue.3, pp.727-762, 2017. ,
DOI : 10.1208/s12248-016-0041-9
URL : https://hal.archives-ouvertes.fr/hal-01518886
Biological and Hemodynamic Effects of Low Doses of Fludrocortisone and Hydrocortisone, Alone or in Combination, in Healthy Volunteers With Hypoaldosteronism, Clinical Pharmacology & Therapeutics, vol.22, issue.2, pp.183-90, 2010. ,
DOI : 10.1161/hy0102.099031
URL : https://hal.archives-ouvertes.fr/hal-00748193
Human plasma quantification of fludrocortisone using liquid chromatography coupled with atmospheric pressure chemical ionization mass spectrometry after low-dosage administration, Clinica Chimica Acta, vol.420, pp.2013109-2013122 ,
DOI : 10.1016/j.cca.2012.11.026
The use of the SAEM algorithm in MONOLIX software for estimation of population pharmacokinetic-pharmacodynamic-viral dynamics parameters of maraviroc in asymptomatic HIV subjects, Journal of Pharmacokinetics and Pharmacodynamics, vol.30, issue.6, pp.41-61, 2011. ,
DOI : 10.1023/B:JOPA.0000012998.04442.1f
URL : https://hal.archives-ouvertes.fr/hal-00637403
Ways to fit a PK model with some data below the quantification limit, J ,
, , pp.481-504, 2001.
Population pharmacokinetic?pharmacodynamic modeling of moxonidine using 24?hour ambulatory blood pressure measurements Available from, Clin Pharmacol Ther [Internet], vol.64, issue.98, pp.9-923690053, 1998. ,
Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: The npde add-on package for R. Comput Methods Programs Biomed, pp.154-66, 2008. ,
URL : https://hal.archives-ouvertes.fr/inserm-00274332
Assessment of Clinical Criteria for Sepsis, JAMA, vol.315, issue.8, pp.762-774, 2016. ,
DOI : 10.1001/jama.2016.0288
Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care, Critical Care Medicine, vol.29, issue.7, pp.1303-1310, 2001. ,
DOI : 10.1097/00003246-200107000-00002
Corticosteroid Treatment and Intensive Insulin Therapy for Septic Shock in Adults: A Randomized Controlled Trial, JAMA, vol.303, pp.341-348, 2010. ,
Corticosteroids in the Treatment of Severe Sepsis and Septic Shock in Adults, JAMA, vol.301, issue.22, pp.2362-2375, 2009. ,
DOI : 10.1001/jama.2009.815
, , 2004.
, Corticosteroids for severe sepsis and septic shock: a systematic review and metaanalysis, BMJ, vol.329, p.480
, , 2015.
, Corticosteroids for treating sepsis, Cochrane Database Syst. Rev, vol.12, p.2243
Septic shock, The Lancet, vol.365, issue.9453, pp.63-78, 2005. ,
DOI : 10.1016/S0140-6736(04)17667-8
Impaired pressor sensitivity to noradrenaline in septic shock patients with and without impaired adrenal function reserve, British Journal of Clinical Pharmacology, vol.329, issue.6, pp.589-597, 1998. ,
DOI : 10.1056/NEJM199312303292706
, , 2006.
, Diagnosis of adrenal insufficiency in severe sepsis and septic shock, Am. J. Respir. Crit
, Care Med, vol.174, pp.1319-1326
Effect of Treatment With Low Doses of Hydrocortisone and Fludrocortisone on Mortality in Patients With Septic Shock, JAMA, vol.288, issue.7, pp.862-871, 2002. ,
DOI : 10.1001/jama.288.7.862
Cognitive decline after sepsis, The Lancet Respiratory Medicine, vol.3, issue.1, pp.61-69, 2015. ,
DOI : 10.1016/S2213-2600(14)70246-2
Adrenal insufficiency, The Lancet, vol.361, issue.9372, pp.1881-1893, 2003. ,
DOI : 10.1016/S0140-6736(03)13492-7
Corticosteroids suppress cyclooxygenase messenger RNA levels and prostanoid synthesis in cultured vascular cells, Biochemical and Biophysical Research Communications, vol.157, issue.3, pp.1159-1163, 1988. ,
DOI : 10.1016/S0006-291X(88)80995-1
A highly sensitive method for the quantification of fludrocortisone in human plasma using ultra-high-performance liquid chromatography tandem mass spectrometry and its pharmacokinetic application, Biomedical Chromatography, vol.877, issue.12, pp.1213-1219, 2015. ,
DOI : 10.1016/j.jchromb.2009.01.003
Bench-to-bedside review: Microvascular dysfunction in sepsis ?hemodynamics, oxygen transport, and nitric oxide, Critical Care, vol.7, issue.5, pp.359-373, 2003. ,
DOI : 10.1186/cc2353
A survey of population analysis methods and software for complex pharmacokinetic and pharmacodynamic models with examples, 2007. ,
, AAPS J, vol.9, p.60
Ways to fit a PK model with some data below the quantification limit, 2001. ,
, J. Pharmacokinet. Pharmacodyn, vol.28, pp.481-504
Principles and Practice of Endocrinology and Metabolism, 2001. ,
Effect of hydrocortisone on phenylephrine??? mean arterial pressure dose-response relationship in septic shock, Clinical Pharmacology & Therapeutics, vol.68, issue.3, pp.293-303, 2000. ,
DOI : 10.1067/mcp.2000.109354
Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis, Chest, vol.101, issue.6, pp.1644-1655, 1992. ,
DOI : 10.1378/chest.101.6.1644
Low-dose hydrocortisone infusion attenuates the systemic inflammatory response syndrome. The Phospholipase A2 Study Group, Clin. Investig, vol.72, pp.782-787, 1994. ,
Cytokines down-regulate ??1-adrenergic receptor expression during endotoxemia, Critical Care Medicine, vol.31, issue.2, pp.566-571, 2003. ,
DOI : 10.1097/01.CCM.0000048621.36569.69
The endothelial mineralocorticoid receptor regulates vasoconstrictor tone and blood pressure, The FASEB Journal, vol.24, issue.7, pp.2454-2463, 2010. ,
DOI : 10.1161/HYPERTENSIONAHA.107.088955
The use of the SAEM algorithm in MONOLIX software for estimation of population pharmacokinetic-pharmacodynamic-viral dynamics parameters of maraviroc in asymptomatic HIV subjects, Journal of Pharmacokinetics and Pharmacodynamics, vol.30, issue.6, pp.41-61, 2011. ,
DOI : 10.1023/B:JOPA.0000012998.04442.1f
A new impedance cardiograph device for the non-invasive evaluation of cardiac output at rest and during exercise: comparison with the "direct" Fick method, European Journal of Applied Physiology, vol.82, issue.4, pp.313-320, 2000. ,
DOI : 10.1007/s004210000226
The immunopathogenesis of sepsis, Nature, vol.288, issue.6917, pp.885-891, 2002. ,
DOI : 10.1038/nature01023
Corticosteroid treatment and intensive insulin therapy for septic shock in adults: a randomized controlled trial, JAMA, vol.303, pp.341-348 ,
Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: The npde add-on package for R, Computer Methods and Programs in Biomedicine, vol.90, issue.2, pp.154-166, 2008. ,
DOI : 10.1016/j.cmpb.2007.12.002
Hydrocortisone Infusion for Severe Community-acquired Pneumonia, American Journal of Respiratory and Critical Care Medicine, vol.171, issue.3, 2005. ,
DOI : 10.1001/archinte.164.6.637
, Respir. Crit. Care Med, vol.171, pp.242-248
, , 2002.
, Cytosine-phosphate-guanine (CpG) motifs are sensitizing agents for lipopolysaccharide in toxic shock model, Intensive Care Med, vol.28, pp.1340-1347
, , 1995.
, Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature, Crit. Care Med, vol.23, pp.1430-1439
, BINDING OF CORTICOSTEROIDS BY PLASMA PROTEINS. II. PAPER ELECTROPHORESIS AND EQUILIBRIUM PAPER ELECTROPHORESIS J. Clin. Invest, vol.12, issue.35, pp.1434-1438, 1956.
Comparison of four basic models of indirect pharmacodynamic responses, Journal of Pharmacokinetics and Biopharmaceutics, vol.29, issue.4, pp.457-478, 1993. ,
DOI : 10.1111/j.1365-2125.1990.tb03622.x
Surviving Sepsis Campaign, Critical Care Medicine, vol.41, issue.2, pp.165-228, 2012. ,
DOI : 10.1097/CCM.0b013e31827e83af
, , 1998.
, Pharmacokinetics and pharmacodynamics of inhaled corticosteroids, J. Allergy Clin. Immunol, vol.101, pp.440-446
Mineralocorticoid effects due to cortisol inactivation overload explain the beneficial use of hydrocortisone in septic shock, Medical Hypotheses, vol.70, issue.1, pp.56-60, 2008. ,
DOI : 10.1016/j.mehy.2007.04.031
Aldosterone and Vascular Mineralocorticoid Receptors in Murine Endotoxic and Human Septic Shock, Crit. Care Med, 2017. ,
Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations, American Journal of Respiratory and Critical Care Medicine, vol.8, issue.3, pp.259-272, 2016. ,
DOI : 10.1001/jama.2014.2637
Benchmarking the Incidence and Mortality of Severe Sepsis in the United States*, Critical Care Medicine, vol.41, issue.5, pp.1167-1174, 2013. ,
DOI : 10.1097/CCM.0b013e31827c09f8
, , 1993.
, Antithrombotic effect of recombinant human soluble thrombomodulin on endotoxininduced disseminated intravascular coagulation in rats, Thromb. Res, vol.71, pp.325-335
EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units, Intensive Care Med, vol.30, pp.580-588, 2004. ,
Population Pharmacokinetic-Pharmacodynamic Model of Oral Fludrocortisone and Intravenous Hydrocortisone in Healthy Volunteers, The AAPS Journal, vol.19, issue.3, pp.727-735, 2017. ,
DOI : 10.1208/s12248-016-0041-9
, , 2008.
, Local and systemic glucocorticoid metabolism in inflammatory arthritis
, Dis, vol.67, pp.1204-1210
Clinical effects of adding fludrocortisone to a hydrocortisone-based shock protocol in hypotensive critically ill children, Intensive Care Medicine, vol.78, issue.3, pp.518-524, 2011. ,
DOI : 10.2223/JPED.912
Population pharmacokinetic-pharmacodynamic modeling of moxonidine using 24-hour ambulatory blood pressure measurements, Clinical Pharmacology & Therapeutics, vol.7, issue.6, 1998. ,
DOI : 10.1007/BF03220008
Efficacy of selective mineralocorticoid and glucocorticoid agonists in canine septic shock, Critical Care Medicine, vol.40, issue.1, 2012. ,
DOI : 10.1097/CCM.0b013e31822efa14
Population Burden of Long-Term Survivorship After Severe Sepsis in Older Americans, Journal of the American Geriatrics Society, vol.299, issue.6, pp.1070-1077, 2012. ,
DOI : 10.1001/jama.299.19.2294
Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis, JAMA, vol.304, issue.16, pp.1787-1794, 2010. ,
DOI : 10.1001/jama.2010.1553
Immunologic and Hemodynamic Effects of ???Low-Dose??? Hydrocortisone in Septic Shock, American Journal of Respiratory and Critical Care Medicine, vol.167, issue.4, pp.512-520 ,
DOI : 10.1001/archinte.1997.00440250031004
Gluco- and mineralocorticoid biological effects of a 7-day treatment with low doses of hydrocortisone and fludrocortisone in septic shock, Intensive Care Medicine, vol.15, issue.8, pp.1306-1314, 2012. ,
DOI : 10.1186/cc10262
Low doses of fludrocortisone and hydrocortisone, alone or in combination, on vascular responsiveness to phenylephrine in healthy volunteers, British Journal of Clinical Pharmacology, vol.29, issue.2, pp.423-430, 2013. ,
DOI : 10.1007/s00134-003-1986-6
Biological and Hemodynamic Effects of Low Doses of Fludrocortisone and Hydrocortisone, Alone or in Combination, in Healthy Volunteers With Hypoaldosteronism, Clinical Pharmacology & Therapeutics, vol.22, issue.2, pp.183-190, 2010. ,
DOI : 10.1161/hy0102.099031
Fludrocortisone and Hydrocortisone, Alone or in Combination, on In Vivo Hemodynamics and In Vitro Vascular Reactivity in Normal and Endotoxemic Rats, Journal of Cardiovascular Pharmacology, vol.63, issue.6, pp.488-496, 2014. ,
DOI : 10.1097/FJC.0000000000000072
Steroid controversy in sepsis and septic shock, Critical Care Medicine, vol.23, issue.7, pp.1294-1303, 1995. ,
DOI : 10.1097/00003246-199507000-00021
, SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference, 2001.
, Crit. Care Med, vol.31, pp.1250-1256
The Epidemiology of Sepsis in the United States from 1979 through 2000, New England Journal of Medicine, vol.348, issue.16, pp.1546-1554, 1979. ,
DOI : 10.1056/NEJMoa022139
Use of Corticosteroids in Treating Infectious Diseases, Archives of Internal Medicine, vol.168, issue.10, p.1034, 2008. ,
DOI : 10.1001/archinte.168.10.1034
Comparative Studies on Adrenal Cortical Function and Cortisol Metabolism in Healthy Adults and in Patients with Shock Due to Infection, Journal of Clinical Investigation, vol.37, issue.12, pp.1791-1798, 1958. ,
DOI : 10.1172/JCI103772
The effects of steroids during sepsis depend on dose and severity of illness: an updated meta-analysis, Clinical Microbiology and Infection, vol.15, issue.4, 2009. ,
DOI : 10.1111/j.1469-0691.2009.02752.x
, Clin. Microbiol. Infect, vol.15, pp.308-318
A sensitive radioimmunoassay for fludrocortisone in human plasma, Steroids, vol.59, issue.9, pp.555-558, 1994. ,
DOI : 10.1016/0039-128X(94)90074-4
Basic Concepts in Population Modeling, Simulation, and Model-Based Drug Development, CPT: Pharmacometrics & Systems Pharmacology, vol.32, issue.9, p.6, 2012. ,
DOI : 10.1007/s10928-005-0062-y
Basic Concepts in Population Modeling, Simulation, and Model-Based Drug Development???Part 2: Introduction to Pharmacokinetic Modeling Methods, CPT: Pharmacometrics & Systems Pharmacology, vol.14, issue.4, p.38, 2013. ,
DOI : 10.1177/0091270010376965
, , 1991.
, Dexamethasone inhibits the induction of monocyte chemotactic-activating factor production by IL-1 or tumor necrosis factor, J. Immunol, vol.146, pp.1212-1215
Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model, Nature Reviews Drug Discovery, vol.3, issue.1, pp.27-41, 2004. ,
DOI : 10.1038/nrd1283
Adrenal Insufficiency, New England Journal of Medicine, vol.335, issue.16, pp.1206-1212, 1996. ,
DOI : 10.1056/NEJM199610173351607
Diagnosis and therapy surveillance in Addison's disease? rapid adrenocorticotropin (ACTH) test and measurement of plasma ACTH, renin activity, and aldosterone, J. Clin. Endocrinol. Metab, vol.75, pp.259-264, 1992. ,
Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock*, Critical Care Medicine, vol.33, issue.11, pp.2457-2464, 2005. ,
DOI : 10.1097/01.CCM.0000186370.78639.23
Molecular Physiology of the Regulation of Hepatic Gluconeogenesis and Glycolysis, Annual Review of Physiology, vol.54, issue.1, pp.885-909, 1992. ,
DOI : 10.1146/annurev.ph.54.030192.004321
Pharmacokinetics of oral fludrocortisone in septic shock, British Journal of Clinical Pharmacology, vol.51, issue.Suppl, pp.1509-1516, 2016. ,
DOI : 10.5414/CP201789
Science review: Mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids, Critical Care, vol.8, issue.4, pp.243-252, 2004. ,
DOI : 10.1186/cc2878
Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells., Proceedings of the National Academy of Sciences, vol.87, issue.24, pp.10043-10047, 1990. ,
DOI : 10.1073/pnas.87.24.10043
The mesenteric hemodynamic response to circulatory shock: an overview, Shock Augusta Ga, vol.15, pp.329-343, 2001. ,
Antiinflammatory Action of Glucocorticoids ??? New Mechanisms for Old Drugs, New England Journal of Medicine, vol.353, issue.16, pp.1711-1723, 2005. ,
DOI : 10.1056/NEJMra050541
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016, Intensive Care Medicine, vol.22, issue.4, pp.304-377, 2017. ,
DOI : 10.1155/2015/532721
Human plasma quantification of fludrocortisone using liquid chromatography coupled with atmospheric pressure chemical ionization mass spectrometry after low-dosage administration, Clinica Chimica Acta, vol.420, pp.109-113, 2013. ,
DOI : 10.1016/j.cca.2012.11.026
Low-dose hydrocortisone during severe sepsis: Effects on microalbuminuria, Critical Care Medicine, vol.34, issue.9, pp.2334-2339, 2006. ,
DOI : 10.1097/01.CCM.0000233872.04706.BB
Mineralocorticoid receptor binding, structure and function, Molecular and Cellular Endocrinology, vol.217, issue.1-2, pp.203-212, 2004. ,
DOI : 10.1016/j.mce.2003.10.021
Dynamic Modeling of Cortisol Reduction after Inhaled Administration of Fluticasone Propionate, The Journal of Clinical Pharmacology, vol.36, issue.Suppl A, pp.938-941, 1996. ,
DOI : 10.1002/j.1552-4604.1996.tb04206.x
Mathematical modeling of cortisol circadian rhythm and cortisol suppression, European Journal of Pharmaceutical Sciences, vol.4, issue.6, pp.341-350, 1996. ,
DOI : 10.1016/S0928-0987(96)00174-1
, , 1996.
Pharmacodynamic Modeling of Cortisol Suppression after Oral Administration of Fluocortolone, J. Clin. Pharmacol, vol.36, pp.311-314 ,
Cortisol response to corticotropin and survival in septic shock, The Lancet, vol.337, issue.8741, pp.582-583, 1991. ,
DOI : 10.1016/0140-6736(91)91641-7
INHIBITION OF NF-??B ACTIVITY PREVENTS DOWNREGULATION OF ??1-ADRENERGIC RECEPTORS AND CIRCULATORY FAILURE DURING CLP-INDUCED SEPSIS, Shock, vol.32, issue.3, pp.239-246, 2009. ,
DOI : 10.1097/SHK.0b013e3181994752
Pharmacologie ? Des concepts fondamentaux aux applications thérapeutiques 3e édition (Paris: Editions Frison-Roche) ,
Effects of epinephrine compared with the combination of dobutamine and norepinephrine on gastric perfusion in septic shock, Clinical Pharmacology & Therapeutics, vol.71, issue.5, pp.381-388, 2002. ,
DOI : 10.1067/mcp.2002.122471
, , 2006.
, Dopexamine and norepinephrine versus epinephrine on gastric perfusion in patients with septic shock: a randomized study, Crit. Care, vol.10, p.32
Assessment of Clinical Criteria for Sepsis, JAMA, vol.315, issue.8, pp.762-774, 2016. ,
DOI : 10.1001/jama.2016.0288
Population modelling in drug development, Statistical Methods in Medical Research, vol.46, issue.3, pp.183-193, 1999. ,
DOI : 10.1007/BF02353487
Modelling of individual pharmacokinetics for computer-aided drug dosage, Computers and Biomedical Research, vol.5, issue.5, pp.411-459, 1972. ,
DOI : 10.1016/0010-4809(72)90051-1
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3), JAMA, vol.315, issue.8, pp.801-810, 2016. ,
DOI : 10.1001/jama.2016.0287
Safety and Efficacy of Corticosteroids for the Treatment of Septic Shock: A Systematic Review and Meta???Analysis, Clinical Infectious Diseases, vol.49, issue.1, pp.93-101, 2009. ,
DOI : 10.1086/599343
, , 2008.
, Hydrocortisone Therapy for Patients with Septic Shock, N. Engl. J. Med, vol.358, pp.111-124
Martindale: the complete drug reference, 2009. ,
The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase, British Journal of Pharmacology, vol.26, issue.7, pp.2845-2851, 1995. ,
DOI : 10.1093/cvr/26.1.48
Basic Concepts in Population Modeling, Simulation, and Model-Based Drug Development: Part 3???Introduction to Pharmacodynamic Modeling Methods, CPT: Pharmacometrics & Systems Pharmacology, vol.4, issue.1, p.88, 2014. ,
DOI : 10.1016/S0009-9236(97)90160-0
, , 2007.
, Evidence of altered cortisol metabolism in critically ill patients: a prospective study, Intensive Care Med, vol.33, pp.1746-1753
The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology, Nuclear Receptor Signaling, vol.4, 2007. ,
DOI : 10.1621/nrs.05012
, Pharmacokinetics of 9 -fluorhydrocortisone]. Arzneimittelforschung, pp.1133-1143, 1971.
Glucocorticosteroids for sepsis: systematic review with meta-analysis and trial sequential analysis, Intensive Care Medicine, vol.16, issue.3, pp.1220-1234, 2015. ,
DOI : 10.1186/cc1498
URL : https://link.springer.com/content/pdf/10.1007%2Fs00134-015-3899-6.pdf
9-Alpha-Fluorocortisol-lnduced Hypertension: A Review, Journal of Hypertension, vol.4, issue.2, pp.133-139, 1986. ,
DOI : 10.1097/00004872-198604000-00002
DIFFERENTIAL BLOOD PRESSURE AND METABOLIC EFFECTS OF 9?-FLUOROCORTISOL IN MAN, Clinical and Experimental Pharmacology and Physiology, vol.39, issue.3, pp.351-354, 1983. ,
DOI : 10.1016/0026-0495(79)90201-4
Understanding the time course of pharmacological effect: a PKPD approach, Br. J. Clin. Pharmacol, vol.71, pp.815-823, 2011. ,
Population Pharmacokinetic-Pharmacodynamic Model of Oral Fludrocortisone and Intravenous Hydrocortisone in Healthy Volunteers, Publications et abstracts publiés à partir de travaux réalisés Publications internationales -Hamitouche N, Comets, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01518886
Pharmacokinetics of oral fludrocortisone in septic shock, British Journal of Clinical Pharmacology, vol.51, issue.Suppl, 2016. ,
DOI : 10.5414/CP201789
,
, Population pharmacodynamics analysis of effect of three increasing doses of fludrocortisone on phenylephrine-mean arterial pressure dose-response relationship in healthy volunteers. Oral Communication Abstracts, Fundam Clin Pharmacol, vol.31, pp.5-20, 2017.
,
Effects of ivabradine on hemodynamics and inflammation in LPS-induced endotoxemic shock in rats. Oral Communication Abstracts, Fundam Clin Pharmacol, vol.30, pp.5-24, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01310759
Population Pharmacokinetic/Pharmacodynamics Modeling of Fludrocortisone and Hydrocortisone, Administered Alone or in Combination, in Healthy Volunteers. Discussed Poster Abstracts, Fundam Clin Pharmacol, vol.29, pp.20-33, 2015. ,
Population pharmacokinetic modeling of oral fludrocortisone in septic shock patients. Poster Abstracts, Fundam Clin Pharmacol, vol.29, pp.47-61, 2015. ,