The Epidemiology of Osteosarcoma, Cancer Treat Res, vol.152, pp.3-13, 2009. ,
DOI : 10.1007/978-1-4419-0284-9_1
A novel orthotopic murine model provides insights into cellular and molecular characteristics contributing to human osteosarcoma, Clinical & Experimental Metastasis, vol.8, issue.1, pp.367-80, 2006. ,
DOI : 10.1093/oxfordjournals.jbchem.a002824
Current Therapeutic Strategies and Novel Approaches in Osteosarcoma, Cancers, vol.2012, issue.4, pp.591-616, 2013. ,
DOI : 10.1155/2012/523432
Chemotherapeutic adjuvant treatment for osteosarcoma: Where do we stand?, European Journal of Cancer, vol.47, issue.16, pp.2431-2476, 1990. ,
DOI : 10.1016/j.ejca.2011.05.030
Dose-Intense Ifosfamide/Doxorubicin/Cisplatin Based Chemotherapy for Osteosarcoma in Adults, American Journal of Clinical Oncology, vol.25, issue.5, pp.489-95, 2002. ,
DOI : 10.1097/00000421-200210000-00014
A review of clinical and molecular prognostic factors in osteosarcoma, Journal of Cancer Research and Clinical Oncology, vol.25, issue.1, pp.281-97, 2008. ,
DOI : 10.3748/wjg.v10.i13.1984
Similarities and Differences in Tumor Growth, Skeletal Remodeling and Pain in an Osteolytic and Osteoblastic Model of Bone Cancer, The Clinical Journal of Pain, vol.22, issue.7, pp.587-600, 2006. ,
DOI : 10.1097/01.ajp.0000210902.67849.e6
Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis., Journal of Clinical Investigation, vol.98, issue.7, pp.1544-1553, 1996. ,
DOI : 10.1172/JCI118947
Breast Cancer Cell Line MDA-231 Stimulates Osteoclastogenesis and Bone Resorption in Human Osteoclasts, Biochemical and Biophysical Research Communications, vol.270, issue.3, pp.1097-100, 2000. ,
DOI : 10.1006/bbrc.2000.2569
The dynamic roles of TGF-?? in cancer, The Journal of Pathology, vol.403, issue.2, pp.205-223, 2011. ,
DOI : 10.1038/35000501
Overexpression of Smad7 Blocks Primary Tumor Growth and Lung Metastasis Development in Osteosarcoma, Clinical Cancer Research, vol.20, issue.19, pp.5097-112, 2014. ,
DOI : 10.1158/1078-0432.CCR-13-3191
Halofuginone: A Novel Antifibrotic Therapy, General Pharmacology: The Vascular System, vol.30, issue.4, pp.445-50, 1998. ,
DOI : 10.1016/S0306-3623(97)00307-8
Phase II AIDS Malignancy Consortium Trial of Topical Halofuginone in AIDS-Related Kaposi Sarcoma, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.56, issue.1, pp.64-72, 1999. ,
DOI : 10.1097/QAI.0b013e3181fc0141
Halofuginone induces the apoptosis of breast cancer cells and inhibits migration via downregulation of matrix metalloproteinase-9, International Journal of Oncology, vol.44, issue.1, pp.309-327, 2014. ,
DOI : 10.3892/ijo.2013.2157
Halofuginone Inhibits the Establishment and Progression of Melanoma Bone Metastases, Cancer Research, vol.72, issue.23, pp.6247-56, 2012. ,
DOI : 10.1158/0008-5472.CAN-12-1444
Halofuginone inhibits multiple myeloma growth in vitro and in vivo and enhances cytotoxicity of conventional and novel agents, British Journal of Haematology, vol.64, issue.6, pp.718-749, 2012. ,
DOI : 10.1124/mol.64.3.707
Inhibition of Pancreatic Stellate Cell Activation by Halofuginone Prevents Pancreatic Xenograft Tumor Development, Pancreas, vol.39, issue.7, pp.1008-1023, 2010. ,
DOI : 10.1097/MPA.0b013e3181da8aa3
INHIBITION OF WILMS TUMOR XENOGRAFT PROGRESSION BY HALOFUGINONE IS ACCOMPANIED BY ACTIVATION OF WT-1 GENE EXPRESSION, The Journal of Urology, vol.174, issue.4, pp.1527-1558, 2005. ,
DOI : 10.1097/01.ju.0000179218.16587.d2
Suppression of hepatocellular carcinoma growth in mice by the alkaloid coccidiostat halofuginone, European Journal of Cancer, vol.40, issue.9, pp.1397-403, 1990. ,
DOI : 10.1016/j.ejca.2003.11.036
Halofuginone: a potent inhibitor of critical steps in angiogenesis progression, The FASEB Journal, vol.14, issue.15, pp.2477-85, 2000. ,
DOI : 10.1007/BF02631124
Inhibition of Neovascularization and Tumor Growth, Facilitation of Wound Repair, by Halofuginone, an Inhibitor of Collagen Type I Synthesis, Neoplasia, vol.1, issue.4, pp.321-330, 1999. ,
DOI : 10.1038/sj.neo.7900043
Growth inhibition of prostate cancer xenografts by halofuginone, The Prostate, vol.51, issue.2, pp.73-83, 2002. ,
DOI : 10.1159/000058059
Amelioration of Radiation-induced Fibrosis, Journal of Biological Chemistry, vol.282, issue.15, pp.15167-76, 2004. ,
DOI : 10.1074/jbc.M300777200
Halofuginone Has Anti-Proliferative Effects in Acute Promyelocytic Leukemia by Modulating the Transforming Growth Factor Beta Signaling Pathway, PLoS ONE, vol.6, issue.10, p.26713, 2011. ,
DOI : 10.1371/journal.pone.0026713.s001
Therapy for Osteosarcoma, Pediatric Drugs, vol.25, issue.31, pp.315-342, 2008. ,
DOI : 10.1007/978-3-642-72643-9_3
Emerging drugs for high-grade osteosarcoma, Expert Opinion on Emerging Drugs, vol.24, issue.4, pp.615-649, 2010. ,
DOI : 10.1586/era.09.7
Update on Targets and Novel Treatment Options for High-Grade Osteosarcoma and Chondrosarcoma, Hematology/Oncology Clinics of North America, vol.27, issue.5, pp.1021-1069, 2013. ,
DOI : 10.1016/j.hoc.2013.07.012
A phase II trial of sorafenib in relapsed and unresectable high-grade osteosarcoma after failure of standard multimodal therapy: an Italian Sarcoma Group study, Annals of Oncology, vol.65, issue.6, pp.508-524, 2012. ,
DOI : 10.1158/0008-5472.CAN-04-3135
Apoptosis: A Review of Programmed Cell Death, Toxicologic Pathology, vol.135, issue.4, pp.495-516, 2007. ,
DOI : 10.1038/sj.embor.7400622
Molecular Mechanisms of Tumor-Bone Interactions in Osteolytic Metastases, Critical Reviews?? in Eukaryotic Gene Expression, vol.10, issue.2, pp.159-78, 2000. ,
DOI : 10.1615/CritRevEukarGeneExpr.v10.i2.50
Tumor-bone cellular interactions in skeletal metastases, J Musculoskelet Neuronal Interact, vol.4, pp.308-326, 2004. ,
Stable overexpression of Smad7 in human melanoma cells inhibits their tumorigenicity in vitro and in vivo, Oncogene, vol.24, issue.51, pp.7624-7633, 2005. ,
DOI : 10.1074/jbc.M309798200
URL : https://hal.archives-ouvertes.fr/inserm-00147458
Stable Overexpression of Smad7 in Human Melanoma Cells Impairs Bone Metastasis, Cancer Research, vol.67, issue.5, pp.2317-2341, 2007. ,
DOI : 10.1158/0008-5472.CAN-06-3950
URL : https://hal.archives-ouvertes.fr/inserm-00147397
TGF?? Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4, Cell, vol.133, issue.1, pp.66-77, 2008. ,
DOI : 10.1016/j.cell.2008.01.046
URL : https://doi.org/10.1016/j.cell.2008.01.046
Inhibition of Breast Cancer Metastasis by Selective Synthetic Polypeptide against CXCR4, Cancer Research, vol.64, issue.12, pp.4302-4310, 2004. ,
DOI : 10.1158/0008-5472.CAN-03-3958
Enhanced tumor regression and tissue repair when zoledronic acid is combined with ifosfamide in rat osteosarcoma, Bone, vol.37, issue.1, pp.74-86, 2005. ,
DOI : 10.1016/j.bone.2005.02.020