Inflammatory subtypes in asthma: Assessment and identification using induced sputum, Respirology, vol.160, issue.1, pp.11-54, 2006. ,
DOI : 10.1164/ajrccm.160.5.9806170
Role of neutrophils in persistent airway obstruction due to refractory asthma, Respirology, vol.2, issue.5, pp.17-322 ,
DOI : 10.4168/aair.2010.2.3.165
Sputum inflammatory phenotypes are not stable in children with asthma, Thorax, vol.67, issue.8, pp.67-675 ,
DOI : 10.1136/thoraxjnl-2011-201064
A large subgroup of mild-to-moderate asthma is persistently noneosinophilic. American journal of respiratory and critical care medicine, pp.185-612, 2012. ,
Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes, Journal of Allergy and Clinical Immunology, vol.125, issue.5, pp.125-1028 ,
DOI : 10.1016/j.jaci.2010.02.008
on behalf of the Epidemiological study on the Genetics and Environment of A. Heterogeneity of asthma according to blood inflammatory patterns, Thorax, issue.5, pp.64-374, 2009. ,
Tackling asthma phenotypes in community studies, Thorax, vol.64, issue.5, pp.369-370, 2009. ,
DOI : 10.1136/thx.2008.109710
What is an ???eosinophilic phenotype??? of asthma?, Journal of Allergy and Clinical Immunology, vol.132, issue.1, pp.81-83 ,
DOI : 10.1016/j.jaci.2013.05.007
Asthma: defining of the persistent adult phenotypes, The Lancet, vol.368, issue.9537, pp.368-804, 2006. ,
DOI : 10.1016/S0140-6736(06)69290-8
Asthma phenotypes: the evolution from clinical to molecular approaches, Nature Medicine, vol.123, issue.5, pp.716-725 ,
DOI : 10.1016/j.jaci.2009.01.057
Asthma outcomes: Biomarkers, Journal of Allergy and Clinical Immunology, vol.129, issue.3, pp.129-138 ,
DOI : 10.1016/j.jaci.2011.12.979
Full blood count parameters for the detection of asthma inflammatory phenotypes, Clinical & Experimental Allergy, vol.29, issue.9, pp.44-1137 ,
DOI : 10.1007/s12032-012-0226-8
Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma, New England Journal of Medicine, vol.371, issue.13, pp.371-1198 ,
DOI : 10.1056/NEJMoa1403290
Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial, The Lancet Respiratory Medicine, vol.3, issue.9, 2015. ,
DOI : 10.1016/S2213-2600(15)00197-6
Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials, The Lancet Respiratory Medicine, vol.3, issue.6, pp.3-435 ,
DOI : 10.1016/S2213-2600(15)00106-X
Neutrophil recruitment by allergens contribute to allergic sensitization and allergic inflammation. Current opinion in allergy and clinical immunology 2016, pp.16-45 ,
Clinical control of asthma associates with measures of airway inflammation, Thorax, vol.68, issue.1, pp.68-87 ,
DOI : 10.1136/thoraxjnl-2012-201861
High Blood Eosinophil Count Is a Risk Factor for Future Asthma Exacerbations in Adult Persistent Asthma, The Journal of Allergy and Clinical Immunology: In Practice, vol.2, issue.6, pp.2-741 ,
DOI : 10.1016/j.jaip.2014.06.005
Importance of concomitant local and systemic eosinophilia in uncontrolled asthma. The European respiratory journal, pp.44-97, 2014. ,
EGEA (Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy)--design issues. EGEA Co-operative Group, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, issue.2, pp.25-44, 1995. ,
EGEA (Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy)--descriptive characteristics, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, vol.4, pp.29-46, 1999. ,
URL : https://hal.archives-ouvertes.fr/hal-00596450
Epidemiological Study of the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy . Phenotype Issues, Am J Respir Crit Care Med, issue.4, pp.156-123, 1997. ,
URL : https://hal.archives-ouvertes.fr/hal-00596474
The European Community Respiratory Health Survey. The European respiratory journal, pp.954-960, 1994. ,
Forced midexpiratory flow between 25% and 75% of forced vital capacity is associated with long-term persistence of asthma and poor asthma outcomes. The Journal of allergy and clinical immunology, 2015. ,
Standardisation of spirometry. The European respiratory journal, pp.26-319, 2005. ,
Full blood count normal reference values for adults in France, Journal of Clinical Pathology, vol.31, issue.4, pp.67-341 ,
DOI : 10.1111/j.1751-553X.2008.01068.x
Eosinophilic Inflammation in Asthma, New England Journal of Medicine, vol.323, issue.15, pp.323-1033, 1990. ,
DOI : 10.1056/NEJM199010113231505
Eosinophilic Phenotypes of Airway Disease, Annals of the American Thoracic Society, vol.372, issue.Supplement, pp.143-149 ,
DOI : 10.1056/NEJMoa1304048
Inflammometry to assess airway diseases. The Lancet, pp.372-1017, 2008. ,
DOI : 10.1016/s0140-6736(08)61421-x
Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects, Journal of Allergy and Clinical Immunology, vol.132, issue.4, pp.821-827 ,
DOI : 10.1016/j.jaci.2013.06.007
High blood eosinophil count is associated with more frequent asthma attacks in asthma patients Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, vol.2014, issue.1, pp.113-132 ,
Blood eosinophil count and prospective annual asthma disease burden: a UK cohort study, The Lancet Respiratory Medicine, vol.3, issue.11, pp.3-849 ,
DOI : 10.1016/S2213-2600(15)00367-7
URL : https://ueaeprints.uea.ac.uk/55452/1/THELANCETRM_D_15_00283R2_noFig2.pdf
Predicting frequent asthma exacerbations using blood eosinophil count and other patient data routinely available in clinical practice, Journal of asthma and allergy, vol.2016, issue.9, pp.1-12 ,
Stability of inflammatory phenotypes in asthma, Thorax, vol.67, issue.8, pp.67-665 ,
DOI : 10.1136/thoraxjnl-2012-201657
Variability of sputum inflammatory cells in asthmatic patients receiving corticosteroid therapy: A prospective study using multiple samples, Journal of Allergy and Clinical Immunology, vol.125, issue.5, pp.125-1161 ,
DOI : 10.1016/j.jaci.2010.02.005
Blood Eosinophil Count Is a Useful Biomarker to Identify Patients with Severe Eosinophilic Asthma, Annals of the American Thoracic Society, vol.133, issue.4, pp.531-536 ,
DOI : 10.1016/j.jaci.2013.06.007
Altered Innate Immune Responses in Neutrophils from Patients with Well- and Suboptimally Controlled Asthma, Mediators of Inflammation, vol.112, issue.6, pp.2015-219374, 2015. ,
DOI : 10.1007/s00018-013-1286-4
Effects of steroid therapy on inflammatory cell subtypes in asthma, Thorax, vol.65, issue.5, pp.65-384 ,
DOI : 10.1136/thx.2009.126722
Identifying adult asthma phenotypes using a clustering approach. The European respiratory journal, pp.38-310, 2011. ,
URL : https://hal.archives-ouvertes.fr/inserm-00728341
Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis, Journal of Allergy and Clinical Immunology, vol.133, issue.6, pp.133-1557, 1555. ,
DOI : 10.1016/j.jaci.2013.10.011
Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program American journal of respiratory and critical care medicine, pp.181-315, 2010. ,
Skin Prick Test positivity * 0 ,
for partly controlled and uncontrolled respectively in a model with adjustment for age and sex ,