Measurement of pediatric regional cerebral blood flow from 6 months to 15 years of age in a clinical population

Aline Carsin-Vu 1, 2, 3 Isabelle Corouge 1, 3 Olivier Commowick 1, 3 Guillaume Bouzillé 4, 5 Christian Barillot 1, 3 Jean-Christophe Ferré 1, 5 Maia Proisy 5, 1
1 VisAGeS - Vision, Action et Gestion d'informations en Santé
INSERM - Institut National de la Santé et de la Recherche Médicale : U1228, Inria Rennes – Bretagne Atlantique , IRISA_D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE
Abstract : Objectives To investigate changes in cerebral blood flow (CBF) in gray matter (GM) between 6 months and 15 years of age and to provide CBF values for the brain, GM, white matter (WM), hemispheres and lobes. Methods Between 2013 and 2016, we retrospectively included all clinical MRI examinations with arterial spin labeling (ASL). We excluded subjects with a condition potentially affecting brain perfusion. For each subject, mean values of CBF in the brain, GM, WM, hemispheres and lobes were calculated. GM CBF was fitted using linear, quadratic and cubic polynomial regression against age. Regression models were compared with Akaike’s information criterion (AIC), and Likelihood Ratio tests. Results 84 children were included (44 females/40 males). Mean CBF values were 64.2 ± 13.8 mL/100 g/min in GM, and 29.3 ± 10.0 mL/100 g/min in WM. The best-fit model of brain perfusion was the cubic polynomial function (AIC = 672.7, versus respectively AIC = 673.9 and AIC = 674.1 with the linear negative function and the quadratic polynomial function). A statistically significant difference between the tested models demonstrating the superiority of the quadratic (p = 0.18) or cubic polynomial model (p = 0.06), over the negative linear regression model was not found. No effect of general anesthesia (p = 0.34) or of gender (p = 0.16) was found. Conclusion we provided values for ASL CBF in the brain, GM, WM, hemispheres, and lobes over a wide pediatric age range, approximately showing inverted U-shaped changes in GM perfusion over the course of childhood.
Type de document :
Article dans une revue
European Journal of Radiology, Elsevier, 2018, 101, pp.38-44. 〈10.1016/j.ejrad.2018.02.003〉
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Contributeur : Isabelle Corouge <>
Soumis le : mercredi 14 février 2018 - 12:14:38
Dernière modification le : mercredi 21 février 2018 - 01:31:26

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Aline Carsin-Vu, Isabelle Corouge, Olivier Commowick, Guillaume Bouzillé, Christian Barillot, et al.. Measurement of pediatric regional cerebral blood flow from 6 months to 15 years of age in a clinical population. European Journal of Radiology, Elsevier, 2018, 101, pp.38-44. 〈10.1016/j.ejrad.2018.02.003〉. 〈inserm-01708945〉

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