?. Stanley, E. Chitu, and V. , CSF-1 Receptor Signaling in Myeloid Cells, Cold Spring Harbor Perspectives in Biology, vol.6, issue.6, p.21857, 2014.
DOI : 10.1101/cshperspect.a021857

?. Dai, X. Ryan, G. Hapel, A. Dominiguez, M. Russel et al., Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects, Blood, vol.99, issue.1, pp.111-120, 2002.
DOI : 10.1182/blood.V99.1.111

?. Wiktor-jedrzejczak, W. Bartocci, A. Ferrante, A. Jr, A. Ahemd-ansari et al., Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse., Proceedings of the National Academy of Sciences, vol.87, issue.12, pp.4828-4832, 1990.
DOI : 10.1073/pnas.87.12.4828

?. Yoshida, H. Hayashi, S. Kunisada, T. Ogawa, M. Nishikawa et al., The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene, Nature, vol.345, issue.6274, pp.442-444
DOI : 10.1038/345442a0

?. Wei, S. Nandi, S. Chitu, V. Yeung, Y. Yu et al., Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells, Journal of Leukocyte Biology, vol.88, issue.3, pp.495-505, 2010.
DOI : 10.1189/jlb.1209822

?. Lin, H. Lee, E. Hestir, K. Leo, C. Huang et al., Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome, Science, vol.2, issue.1, pp.807-811, 2008.
DOI : 10.1182/blood.V99.1.111

?. Foucher, E. Blanchard, S. Preisser, L. Garo, E. Ifrah et al., IL-34 Induces the Differentiation of Human Monocytes into Immunosuppressive Macrophages. Antagonistic Effects of GM-CSF and IFN??, PLoS ONE, vol.145, issue.2, p.56045, 2013.
DOI : 10.1371/journal.pone.0056045.s004

?. Baud-'huin, M. , R. R. Charrier, C. Riet, A. Moreau et al., Interleukin-34 is expressed by giant cell tumours of bone and plays a key role in RANKL-induced osteoclastogenesis, The Journal of Pathology, vol.102, issue.1, pp.77-86, 2010.
DOI : 10.1016/S0002-9440(10)64556-7

?. Nandi, S. Gokhan, S. Dai, X. Wei, S. Enikolopov et al., The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation, Developmental Biology, vol.367, issue.2, pp.100-113, 2012.
DOI : 10.1016/j.ydbio.2012.03.026

URL : https://doi.org/10.1016/j.ydbio.2012.03.026

?. Wang, Y. Szretter, K. Vermi, W. Gilfillan, S. Rossini et al., IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia, Nature Immunology, vol.165, issue.8, pp.753-760, 2012.
DOI : 10.1016/j.immuni.2011.06.005

?. Chihara, T. Suzu, S. Hassan, R. Chutiwitoonchai, N. Hiyoshi et al., IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation, Cell Death and Differentiation, vol.145, issue.12, pp.1917-1927
DOI : 10.1093/nar/22.22.4673

?. Liu, H. Leo, C. Chen, X. Wong, B. Williams et al., The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, vol.1824, issue.7, pp.938-945, 2012.
DOI : 10.1016/j.bbapap.2012.04.012

?. Pandit, J. Bohm, A. Jancarik, J. Halenbeck, R. Koths et al., Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor, Science, vol.258, issue.5086, pp.1358-1362, 1992.
DOI : 10.1126/science.1455231

?. Garceau, V. Smith, J. Paton, I. Davey, M. Fares et al., Pivotal Advance: Avian colony-stimulating factor 1 (CSF-1), interleukin-34 (IL-34), and CSF-1 receptor genes and gene products, Journal of Leukocyte Biology, vol.87, issue.5, pp.753-764, 2010.
DOI : 10.1189/jlb.0909624

?. Ma, X. Lin, W. Chen, Y. Stawicki, S. Mukhyala et al., Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R, Structure, vol.20, issue.4, pp.676-687, 2012.
DOI : 10.1016/j.str.2012.02.010

?. Price, K. Choi, H. Rosenberg, L. Stanley, and E. , The predominant form of secreted colony stimulating factor-1 is a proteoglycan, J. Biol. Chem, vol.267, pp.2190-2199, 1992.

?. Verstraete, K. Savvides, and S. , Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases, Nature Reviews Cancer, vol.12, issue.11, pp.753-766, 2012.
DOI : 10.1016/j.ccr.2007.11.005

?. Elegheert, J. Desfosses, A. Shkumatov, A. Wu, X. Bracke et al., Extracellular Complexes of the Hematopoietic Human and Mouse CSF-1 Receptor Are Driven by Common Assembly Principles, Structure, vol.19, issue.12, pp.1762-1772, 2011.
DOI : 10.1016/j.str.2011.10.012

URL : https://hal.archives-ouvertes.fr/hal-01243659

?. Reynolds, A. Leake, D. Boese, Q. Scaringe, S. Marshall et al., Rational siRNA design for RNA interference, Nature Biotechnology, vol.94, issue.3, pp.326-330, 2004.
DOI : 10.1073/pnas.94.9.4360

?. Naito, Y. Ui-tei, and K. , Designing Functional siRNA with Reduced Off-Target Effects, Methods Mol Biol, vol.942, pp.57-68, 2013.
DOI : 10.1007/978-1-62703-119-6_3

?. Hellemans, J. Vandesompele, and J. , Selection of Reliable Reference Genes for RT-qPCR Analysis, Methods Mol Biol, vol.1160, pp.19-26, 2014.
DOI : 10.1007/978-1-4939-0733-5_3

?. Bustin, S. Benes, V. Garson, J. Hellemans, J. Huggett et al., The need for transparency and good practices in the qPCR literature, Nature Methods, vol.496, issue.11, pp.1063-1067, 2013.
DOI : 10.1038/nrd1012

. Sa, The digital MIQE guidelines: Minimum Information for Publication of Quantitative Digital PCR Experiments, Clin Chem, vol.59, pp.892-902, 2013.

?. Chen, R. Weng, and Z. , Docking unbound proteins using shape complementarity, desolvation, and electrostatics, Proteins: Structure, Function, and Genetics, vol.8, issue.3, pp.281-294, 2002.
DOI : 10.1110/ps.8.3.603

?. Momany, F. Rone, and R. , Validation of the general purpose QUANTA ??3.2/CHARMm?? force field, Journal of Computational Chemistry, vol.24, issue.7, pp.888-900, 1992.
DOI : 10.1002/jcc.540090105

?. Chen, X. Liu, H. Focia, P. Shim, A. He et al., Structure of macrophage colony stimulating factor bound to FMS: Diverse signaling assemblies of class III receptor tyrosine kinases, Proceedings of the National Academy of Sciences, vol.272, issue.10, pp.18267-18272, 2008.
DOI : 10.1074/jbc.272.10.6311

?. Li, L. Chen, R. Weng, and Z. , RDOCK: Refinement of rigid-body protein docking predictions, Proteins: Structure, Function, and Genetics, vol.288, issue.3, pp.693-707, 2003.
DOI : 10.1002/prot.10460

URL : http://zlab.umassmed.edu/zdock/RDOCK.pdf

?. Pierce, B. Weng, and Z. , ZRANK: Reranking protein docking predictions with an optimized energy function, Proteins: Structure, Function, and Bioinformatics, vol.16, issue.4, pp.1078-1086, 2007.
DOI : 10.1103/PhysRevE.73.061902

?. Barve, B. Zack, M. Weiss, D. Song, R. Beidler et al., Transcriptional profiling and pathway analysis of CSF-1 and IL-34 effects on human monocyte differentiation, Cytokine, vol.63, issue.1, pp.10-17
DOI : 10.1016/j.cyto.2013.04.019

?. Kozakov, D. Beglov, D. Bohnuud, T. Mottarella, S. Xia et al., How good is automated protein docking?, Proteins: Structure, Function, and Bioinformatics, vol.70, issue.12, pp.2159-2166
DOI : 10.1002/prot.24343

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934018/pdf

?. Kozakov, D. Brenke, R. Comeau, S. Vajda, and S. , PIPER: An FFT-based protein docking program with pairwise potentials, Proteins: Structure, Function, and Bioinformatics, vol.100, issue.2, pp.392-406, 2006.
DOI : 10.1110/ps.8.3.603

URL : http://arxiv.org/pdf/q-bio/0605018

?. Söderberg, O. Gullberg, M. Jarvius, M. Ridderstråle, K. Leuchowius et al., Direct observation of individual endogenous protein complexes in situ by proximity ligation, Nature Methods, vol.42, issue.12, pp.995-1000, 2006.
DOI : 10.1177/42.8.8027531

?. Goodsell, D. Olson, and A. , Structural Symmetry and Protein Function, Annual Review of Biophysics and Biomolecular Structure, vol.29, issue.1, pp.105-153, 2000.
DOI : 10.1146/annurev.biophys.29.1.105

?. Atanasova, M. Whitty, and A. , Understanding cytokine and growth factor receptor activation mechanisms, Critical Reviews in Biochemistry and Molecular Biology, vol.354, issue.2, pp.502-530, 2012.
DOI : 10.1016/j.jmb.2005.10.014

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537265/pdf

?. Gately, M. Renzetti, L. Magram, J. Stern, A. Adorini et al., THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses, Annual Review of Immunology, vol.16, issue.1, pp.495-521, 1998.
DOI : 10.1146/annurev.immunol.16.1.495

?. Kawasaki, E. Ladner, and M. , Molecular biology of macrophage colony-stimulating factor, Immunol Ser, vol.49, pp.155-176, 1990.

?. Hassan, R. Suzu, S. Hiyoshi, M. Takahashi-makise, N. Ueno et al., -glycosylation of a cytokine receptor Fms, Journal of Cellular Physiology, vol.136, issue.2, pp.458-468, 2009.
DOI : 10.4049/jimmunol.180.2.1107

?. Hiyoshi, M. Suzu, S. Yoshidomi, Y. Hassan, R. Harada et al., Interaction between Hck and HIV-1 Nef negatively regulates cell surface expression of M-CSF receptor, Blood, vol.111, issue.1, pp.243-250, 2008.
DOI : 10.1182/blood-2007-04-086017

?. Price, N. Tsvetanova, and B. , Biosynthesis of the Tunicamycins: A Review, The Journal of Antibiotics, vol.176, issue.8, pp.485-491, 2007.
DOI : 10.1042/bj2260817

?. Nebenführ, A. Ritzenthaler, C. Robinson, and D. , Brefeldin A: Deciphering an Enigmatic Inhibitor of Secretion, PLANT PHYSIOLOGY, vol.130, issue.3, pp.1102-1108, 2002.
DOI : 10.1104/pp.011569

A. Verbert and R. Cacan, Trafficking of oligomannosides released during N-glycosylation: a clearing mechanism of the rough endoplasmic reticulum, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1473, issue.1, pp.137-146, 1999.
DOI : 10.1016/S0304-4165(99)00174-9

?. Nandi, S. Cioce, M. Yeung, Y. Nieves, E. Tesfa et al., Receptor-type Protein-tyrosine Phosphatase ?? Is a Functional Receptor for Interleukin-34, Journal of Biological Chemistry, vol.269, issue.30, pp.21972-21986, 2013.
DOI : 10.1038/74805

?. Masteller, E. Wong, and B. , Targeting IL-34 in chronic inflammation, Drug Discovery Today, vol.19, issue.8, pp.1212-1216, 2014.
DOI : 10.1016/j.drudis.2014.05.016

URL : https://doi.org/10.1016/j.drudis.2014.05.016

?. Chemel, M. , L. Goff, B. Brion, R. Cozic et al., Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patients, Annals of the Rheumatic Diseases, vol.71, issue.1, pp.71150-154, 2012.
DOI : 10.1136/annrheumdis-2011-200096

URL : https://hal.archives-ouvertes.fr/inserm-00667486

?. Preisser, L. Miot, C. , L. Guillou-guillemette, H. Beaumont et al., IL-34 and macrophage colony-stimulating factor are overexpressed in hepatitis C virus fibrosis and induce profibrotic macrophages that promote collagen synthesis by hepatic stellate cells, Hepatology, vol.176, issue.1, pp.601879-1090, 2014.
DOI : 10.1164/rccm.200609-1279OC

A. Ortenzi, F. Laudisi, G. Sica, P. Sileri, F. Pallone et al., Interleukin-34 sustains inflammatory pathways in the gut, Clin Sci

?. Fend, L. Accart, N. Kintz, J. Cochin, S. Reymann et al., Therapeutic Effects of Anti-CD115 Monoclonal Antibody in Mouse Cancer Models through Dual Inhibition of Tumor-Associated Macrophages and Osteoclasts, PLoS ONE, vol.5, issue.9, p.73310, 2013.
DOI : 10.1371/journal.pone.0073310.s004