Vendée and Finistère from the Ligue Nationale contre le Cancer, to EBC (2013?2014); by a grant from the Cancéropôle Grand Ouest and Région Pays de la Loire, to SH (2015?2016); by a grant from the Cancéropôle Grand Ouest and Région Centre, to EP); by NIH P50GM085273 to BW; and awards from the Gillson-Longenbaugh Foundation to RP and WA. This work has been funded, in part, by a UNM Cancer Center Support Grant (P30 CA118100) to RP and WA. The INCa financed the salary of DF, The study was supported by grant number 2010-088 from Institut National du Cancer (INCa), to SH and EBC the Cancéropôle Grand Ouest and Région Pays de la Loire financed the salary of AB (HII-GO project) and the Academic Science Education and Research Training-Institutional Research and Academic Career Development Award (ASERT IRACDA, grant number NIGMS K12 GM088021) supported the salary of Alfreda, pp.2015-2016, 2010. ,
Monoclonal gammopathy of undetermined significance, The American Journal of Medicine, vol.64, issue.5, pp.814-826, 1978. ,
DOI : 10.1016/0002-9343(78)90522-3
URL : https://hal.archives-ouvertes.fr/hal-00945713
MGUS to myeloma: a mysterious gammopathy of underexplored significance, Blood, vol.128, issue.23, pp.2599-2606, 2016. ,
DOI : 10.1182/blood-2016-09-692954
Smoldering Multiple Myeloma, New England Journal of Medicine, vol.302, issue.24, pp.1347-1349, 1980. ,
DOI : 10.1056/NEJM198006123022405
URL : https://hal.archives-ouvertes.fr/hal-00557757
International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma, The Lancet Oncology, vol.15, issue.12, pp.538-548, 2014. ,
DOI : 10.1016/S1470-2045(14)70442-5
Oligo-monoclonal immunoglobulins frequently develop during concurrent cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections in patients after renal transplantation, Clinical and Experimental Immunology, vol.377, issue.3, pp.465-472, 1999. ,
DOI : 10.1002/(SICI)1096-9071(199904)57:4<383::AID-JMV10>3.0.CO;2-3
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905451/pdf
Monoclonal gammopathy of undetermined significance (MGUS) is associated with an increased frequency of Epstein-Barr Virus (EBV) latently infected B lymphocytes in long-term renal transplant patients, Transplantation Proceedings, vol.36, issue.9, pp.2679-2682, 2004. ,
DOI : 10.1016/j.transproceed.2004.09.046
Helicobacter pylori infection and monoclonal gammopathy of undetermined significance, British Journal of Haematology, vol.31, issue.3, pp.706-708, 2002. ,
DOI : 10.1056/NEJM199510123331508
URL : http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2141.2002.03912.x/pdf
Global burden of cancers attributable to infections in 2012: a synthetic analysis, The Lancet Global Health, vol.4, issue.9, pp.609-616, 2016. ,
DOI : 10.1016/S2214-109X(16)30143-7
Origin and Pathogenesis of B Cell Lymphomas, Methods Mol Biol, vol.971, pp.1-25, 2013. ,
DOI : 10.1007/978-1-62703-269-8_1
Infection with Hepatitis B and C Viruses and Risk of Lymphoid Malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC), Cancer Epidemiology Biomarkers & Prevention, vol.20, issue.1, pp.208-214, 2011. ,
DOI : 10.1158/1055-9965.EPI-10-0889
URL : https://hal.archives-ouvertes.fr/hal-00811971
Epstein-Barr Virus-Associated B-cell Lymphomas: Pathogenesis and Clinical Outcomes, Clinical Cancer Research, vol.17, issue.10, pp.3056-3063, 2011. ,
DOI : 10.1158/1078-0432.CCR-10-2578
URL : http://clincancerres.aacrjournals.org/content/clincanres/17/10/3056.full.pdf
Hepatitis C Virus, Human Herpesvirus 8, and the Development of Plasma-Cell Leukemia, New England Journal of Medicine, vol.348, issue.2, pp.178-179, 2003. ,
DOI : 10.1056/NEJM200301093480219
Hepatitis C virus (HCV) infection, monoclonal immunoglobulin specific for HCV core protein, and plasma-cell malignancy, Blood, vol.112, issue.10, pp.4357-4358, 2008. ,
DOI : 10.1182/blood-2008-07-167569
URL : http://www.bloodjournal.org/content/bloodjournal/112/10/4357.full.pdf
Regression of a case of Multiple Myeloma with antiviral treatment in a patient with chronic HCV infection, Leukemia Research Reports, vol.2, issue.1, pp.39-40, 2013. ,
DOI : 10.1016/j.lrr.2013.01.002
Multiplexed infectious protein microarray immunoassay suitable for the study of the specificity of monoclonal immunoglobulins, Analytical Biochemistry, vol.433, issue.2, pp.202-209, 2013. ,
DOI : 10.1016/j.ab.2012.10.012
URL : https://hal.archives-ouvertes.fr/inserm-01401584
Characterization of immunoglobulins through analysis of N-glycopeptides by MALDI-TOF MS, Methods, vol.104, pp.170-181, 2016. ,
DOI : 10.1016/j.ymeth.2016.01.005
Viral immunology Comprehensive serological profiling of human populations using a synthetic human virome, Science, vol.348, issue.6239, p.698, 2015. ,
Fingerprinting the circulating repertoire of antibodies from cancer patients, Nature Biotechnology, vol.4, issue.1, pp.57-63, 2003. ,
DOI : 10.1002/pros.2990210521
Elevated serum concentrations of hepatocyte growth factor in patients with multiple myeloma. The Nordic Myeloma Study Group, Blood, vol.91, issue.3, pp.806-812, 1998. ,
Clinical significance of vascular endothelial growth factor and hepatocyte growth factor in multiple myeloma, British Journal of Haematology, vol.324, issue.4, pp.796-802, 2002. ,
DOI : 10.1074/jbc.271.2.603
Play a Significant Role in the Progression of Multiple Myeloma, Journal of Cancer, vol.5, issue.7, pp.518-524, 2014. ,
DOI : 10.7150/jca.9266
Inflammatory markers and development of symptom burden in patients with multiple myeloma during autoloinsight .jci.org https ,
The role of IL-22 in viral infections: paradigms and paradoxes, Front Immunol, vol.7, p.211, 2016. ,
Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22, Nature Immunology, vol.148, issue.5, pp.383-390, 2011. ,
DOI : 10.1164/ajrccm/148.6_Pt_1.1523
IL-26: An Emerging Proinflammatory Member of the IL-10 Cytokine Family with Multifaceted Actions in Antiviral, Antimicrobial, and Autoimmune Responses, PLOS Pathogens, vol.24, issue.et al., p.1005624, 2016. ,
DOI : 10.1371/journal.ppat.1005624.g002
URL : https://hal.archives-ouvertes.fr/hal-01340570
Interleukin-33 in health and disease, Nature Reviews Immunology, vol.2013, issue.11, pp.676-689, 2016. ,
DOI : 10.1186/ar4143
Incidence of Monoclonal Gammopathy of Undetermined Significance and Estimation of Duration Before First Clinical Recognition, Mayo Clinic Proceedings, vol.87, issue.11, pp.1071-1079, 2012. ,
DOI : 10.1016/j.mayocp.2012.06.014
The Tao of myeloma, Blood, vol.124, issue.12, pp.1873-1879, 2014. ,
DOI : 10.1182/blood-2014-05-578732
Qualitative and quantitative analysis of human herpesviruses in chronic and acute B cell lymphocytic leukemia and in multiple myeloma, Leukemia, vol.15, issue.1, pp.185-195, 2003. ,
DOI : 10.1038/sj.leu.2402049
B Cell Antigen Receptor Signaling: Roles in Cell Development and Disease, Science, vol.296, issue.5573, pp.1641-1642, 2002. ,
DOI : 10.1126/science.1071546
Insights into Herpesvirus Tegument Organization from Structural Analyses of the 970 Central Residues of HSV-1 UL36 Protein, Journal of Biological Chemistry, vol.73, issue.14, pp.8820-8833, 2015. ,
DOI : 10.1128/JVI.00971-14
URL : https://hal.archives-ouvertes.fr/hal-01448263
XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome, Nature, vol.101, issue.7115, pp.110-114, 2006. ,
DOI : 10.1016/S0092-8674(00)80828-4
XMEN disease: a new primary immunodeficiency affecting Mg2+ regulation of immunity against Epstein-Barr virus, Blood, vol.123, issue.14, pp.2148-2152, 2014. ,
DOI : 10.1182/blood-2013-11-538686
Inherited CD70 deficiency in humans reveals a critical role for the CD70???CD27 pathway in immunity to Epstein-Barr virus infection, The Journal of Experimental Medicine, vol.153, issue.1, pp.73-89, 2017. ,
DOI : 10.1128/JVI.03305-12
The role of Helicobacter pylori infection in hematological disorders, European Journal of Internal Medicine, vol.24, issue.8, pp.685-690, 2013. ,
DOI : 10.1016/j.ejim.2013.02.011
Epstein???Barr virus infection is associated to patients with multiple myeloma and monoclonal gammopathy of undetermined significance, Leukemia & Lymphoma, vol.8, issue.2, pp.466-469, 2017. ,
DOI : 10.1038/sj.onc.1207905
The spectrum of MALT lymphoma at different sites: biological and therapeutic relevance, Blood, vol.127, issue.17, pp.2082-2092, 2016. ,
DOI : 10.1182/blood-2015-12-624304
B cells under influence: transformation of B cells by Epstein???Barr virus, Nature Reviews Immunology, vol.3, issue.10, pp.801-812, 2003. ,
DOI : 10.1038/nri1201
Epstein???Barr virus latent genes, Experimental & Molecular Medicine, vol.11, issue.1, p.131, 2015. ,
DOI : 10.1371/journal.pone.0010126
URL : http://www.nature.com/emm/journal/v47/n1/pdf/emm201484a.pdf
Epstein-Barr Nuclear Antigen 1 Contributes to Nasopharyngeal Carcinoma through Disruption of PML Nuclear Bodies, PLoS Pathogens, vol.4, issue.10, p.1000170, 2008. ,
DOI : 10.1371/journal.ppat.1000170.s003
URL : https://doi.org/10.1371/journal.ppat.1000170
Contributions of Epstein???Barr Nuclear Antigen 1 (EBNA1) to Cell Immortalization and Survival, Viruses, vol.106, issue.12, pp.1537-1547, 2012. ,
DOI : 10.1128/MCB.23.19.6901-6908.2003
URL : http://www.mdpi.com/1999-4915/4/9/1537/pdf
Targeting of EBNA1 for Rapid Intracellular Degradation Overrides the Inhibitory Effects of the Gly-Ala Repeat Domain and Restores CD8+ T Cell Recognition, Journal of Biological Chemistry, vol.71, issue.36, pp.33353-33360, 2001. ,
DOI : 10.1016/S1097-2765(00)00074-5
Bortezomib Induces Apoptosis of Epstein-Barr Virus (EBV)-Transformed B Cells and Prolongs Survival of Mice Inoculated with EBV-Transformed B Cells, Journal of Virology, vol.81, issue.18, pp.10029-10036, 2007. ,
DOI : 10.1128/JVI.02241-06
Proteasome inhibitors induce the presentation of an Epstein-Barr virus nuclear antigen 1-derived cytotoxic T lymphocyte epitope in Burkitt???s lymphoma cells, Immunology, vol.81, issue.1, pp.105-114, 2011. ,
DOI : 10.1128/JVI.02241-06
Bortezomib and SAHA Synergistically Induce ROS-Driven Caspase-Dependent Apoptosis of Nasopharyngeal Carcinoma and Block Replication of Epstein-Barr Virus, Molecular Cancer Therapeutics, vol.12, issue.5, pp.747-758, 2013. ,
DOI : 10.1158/1535-7163.MCT-12-0811
Clonal Immunoglobulin against Lysolipids in the Origin of Myeloma, New England Journal of Medicine, vol.374, issue.6, pp.555-561, 2016. ,
DOI : 10.1056/NEJMoa1508808
An HSP90-mimic peptide revealed by fingerprinting the pool of antibodies from ovarian cancer patients, Oncogene, vol.23, issue.55, pp.8859-8867, 2004. ,
DOI : 10.1054/bjoc.1999.0881
The Original Pathologische Anatomie Leiden-Endothelium Monoclonal Antibody Recognizes a Vascular Endothelial Growth Factor Binding Site within Neuropilin-1, Cancer Research, vol.67, issue.20, pp.9623-9629, 2007. ,
DOI : 10.1158/0008-5472.CAN-07-2737
From combinatorial peptide selection to drug prototype (II): Targeting the epidermal growth factor receptor pathway, Proceedings of the National Academy of Sciences, vol.4, issue.5, pp.5118-5123, 2010. ,
DOI : 10.1002/pmic.200300680
Discovery and horizontal follow-up of an autoantibody signature in human prostate cancer, Proceedings of the National Academy of Sciences, vol.45, issue.8 Pt 1, pp.2515-2520, 2015. ,
DOI : 10.1126/science.1696028