The mitochondrial respiratory chain: A metabolic rheostat of innate immune cell-mediated antibacterial responses

Abstract : Upon microbial infection, cells of the innate immune system undergo profound metabolic reprogramming in order to eradicate pathogens, promote inflammation, and eventually restore tissue homeostasis. Mitochondria are at the core of these adaptations, given their dual role as metabolic hubs and innate immune signaling platforms. The mitochondrial electron transport chain (ETC) is very well characterized at the genetic, molecular, structural, and biochemical level. In contrast, the role for mitochondrial ETC and metabolites beyond fulfilling cellular ATP synthesis in innate immune cell biology was not understood until recently. Here we discuss the latest advances in our understanding of immune functions of mitochondria and particularly the mitochondrial respiratory chain.
Type de document :
Article dans une revue
Mitochondrion, Elsevier, 2017, 17 (9), pp.1037 - 1045. 〈10.1016/j.mito.2017.10.008〉
Liste complète des métadonnées

Littérature citée [108 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-01621406
Contributeur : Johan Garaude <>
Soumis le : lundi 23 octobre 2017 - 13:40:08
Dernière modification le : mercredi 25 octobre 2017 - 17:20:33
Document(s) archivé(s) le : mercredi 24 janvier 2018 - 14:37:50

Fichier

Garaude_review-Mitochondrion-R...
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Leif E Sander, Johan Garaude. The mitochondrial respiratory chain: A metabolic rheostat of innate immune cell-mediated antibacterial responses. Mitochondrion, Elsevier, 2017, 17 (9), pp.1037 - 1045. 〈10.1016/j.mito.2017.10.008〉. 〈inserm-01621406〉

Partager

Métriques

Consultations de la notice

28

Téléchargements de fichiers

5