Motivators and barriers of tamoxifen use as risk-reducing medication amongst women at increased breast cancer risk: a systematic literature review

Abstract : AbstractBackgroundSelective estrogen receptor modulators, such as tamoxifen, reduce breast cancer risk by up to 50% in women at increased risk for breast cancer. Despite tamoxifen’s well-established efficacy, many studies show that most women are not taking up tamoxifen. This systematic literature review aimed to identify the motivators and barriers to tamoxifen use ‘s amongst high-risk women.MethodsUsing MEDLINE, PsycINFO, and Embase plus reviewing reference lists of relevant articles published between 1995 and 2016, 31 studies (published in 35 articles) were identified, which addressed high-risk women’s decisions about risk-reducing medication to prevent breast cancer and were peer-reviewed primary clinical studies.ResultsA range of factors were identified as motivators of, and barriers to, tamoxifen uptake including: perceived risk, breast-cancer-related anxiety, health professional recommendation, perceived drug effectiveness, concerns about side-effects, knowledge and access to information about side-effects, beliefs about the role of risk-reducing medication, provision of a biomarker, preference for other forms of breast cancer risk reduction, previous treatment experience, concerns about randomization in clinical trial protocols and finally altruism.ConclusionsResults indicate that the decision for high-risk women regarding tamoxifen use or non-use as a risk-reducing medication is not straightforward. Support of women making this decision is essential and needs to encompass the full range of factors, both informational and psychological.
Type de document :
Article dans une revue
Hereditary Cancer in Clinical Practice, BioMed Central, 2016, 15 (1), pp.14. 〈10.1186/s13053-017-0075-8〉
Liste complète des métadonnées

Littérature citée [53 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-01592400
Contributeur : Bmc Bmc <>
Soumis le : dimanche 24 septembre 2017 - 06:09:33
Dernière modification le : mercredi 20 juin 2018 - 11:56:11
Document(s) archivé(s) le : lundi 25 décembre 2017 - 12:20:18

Fichier

13053_2017_Article_75.pdf
Publication financée par une institution

Identifiants

Collections

Citation

Bettina Meiser, W. K. Tim Wong, Michelle Peate, Claire Julian-Reynier, Judy Kirk, et al.. Motivators and barriers of tamoxifen use as risk-reducing medication amongst women at increased breast cancer risk: a systematic literature review. Hereditary Cancer in Clinical Practice, BioMed Central, 2016, 15 (1), pp.14. 〈10.1186/s13053-017-0075-8〉. 〈inserm-01592400〉

Partager

Métriques

Consultations de la notice

27

Téléchargements de fichiers

33