F. Gaudin, M. Bachelerie, A. Espéli, and K. Dalloul, Balabanian are members of the LabEx LER MIT supported by ANR grant ANR-10-LABX-33 under the program Investissements d'Avenir ANR-11-IDEX-0003-01 This study was supported bythe Fondation de France (grant 2013 00038290) to F. Louache. C. Freitas was supported by DIM Biotherapies and the Sociéte Française d'Hématologie. J. Nguyen was a PhD fellow from the DIM Cancéropôle. V. Rondeau was supported by the Fondation pour la Recherche Médicale (FRM, grant ECO20160736102). V. Biajoux was supported by fellowships from the French Ministry for Education and the FRM. The authors declare no competing financial interests. Author contributions: C. Freitas designed and performed most of the experiments and contributed to manuscript writing, and V. Biajoux performed some of the experiments, analyzed data, and reviewed the manuscript ; M.-L. Aknin and F. Gaudin performed some of the experiments and analyzed data; S. Beaussant-Cohen, Y. Bertrand, and J. Donadieu provided blood samples from healthy and patients with WS and reviewed the manuscript; C. Bellanné-Chantelot performed the genetic analyses and reviewed the manuscript; F. Bachelerie and M

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