Epidemiological assessment of the severity of dengue epidemics in French Guiana

Abstract : BACKGROUND: Dengue fever is the most important arboviral infection that affects humans, particularly in tropical and subtropical regions. Here, we provide the first comprehensive overview of the severity of dengue epidemics in French Guiana. METHODOLOGY/PRINCIPAL FINDINGS: We monitored hospitalized cases between 2008 and 2013. Detailed clinical features and biological parameters were collected on a daily basis from all cases. Among the 1,356 cases, 216 (16%) were classified according to the WHO 2009 classification as dengue without warning signs (WS), 926 (68%) were classified as dengue with WS and 214 (16%) were classified as severe dengue. The severity rates were similar between the three major epidemics that occurred during the study period, whereas the hospitalization rate was highest in 2013. Fluid accumulation, aspartate aminotransferase (ASAT) counts>193 IU/L and platelet counts<75,000 cells/mm3 were associated with dengue severity. CONCLUSIONS/SIGNIFICANCE: Our findings provide a recent epidemiological description of the severity of dengue epidemics in French Guiana. These results highlight the potential impacts and consequences of implementing the WHO 2009 classification on hospital activity. Future studies should include virological and immunological investigations of well-documented serum samples
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PLoS ONE, Public Library of Science, 2017, 12 (2), pp.e0172267. 〈10.1371/journal.pone.0172267.t003〉
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Contributeur : Inserm Cic1424 Centre d'Investigation Clinique Antilles Guyane <>
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Claude Flamand, Camille Fritzell, Christelle Prince, Philippe Abboud, Vanessa Ardillon, et al.. Epidemiological assessment of the severity of dengue epidemics in French Guiana. PLoS ONE, Public Library of Science, 2017, 12 (2), pp.e0172267. 〈10.1371/journal.pone.0172267.t003〉. 〈inserm-01481447〉

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