p38 MAP-Kinases pathway regulation, function and role in human diseases, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1773, issue.8, pp.1358-1375, 2007. ,
DOI : 10.1016/j.bbamcr.2007.03.010
Protein kinase cascades activated by stress and inflammatory cytokines, BioEssays, vol.270, issue.7, pp.567-577, 1996. ,
DOI : 10.1002/bies.950180708
(MAPK): stress responses from molecular mechanisms to therapeutics, Trends Mol. Med, vol.15, issue.8, pp.38-369, 2009. ,
DOI : 10.1016/j.molmed.2009.06.005
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016890
Oxidative Stress??Induced Actin Reorganization Mediated by the p38 Mitogen-Activated Protein Kinase/Heat Shock Protein 27 Pathway in Vascular Endothelial Cells, Circulation Research, vol.80, issue.3, pp.383-392, 1997. ,
DOI : 10.1161/01.RES.80.3.383
Activation of p38 mitogen-activated protein kinase by c-Abl-dependent and -independent mechanisms, J. Biol. Chem, issue.39, pp.271-23775, 1996. ,
Identification of anisomycin-activated kinases p45 and p55 in murine cells as MAPKAP ki- nase-2, Oncogene, vol.12, issue.4, pp.805-812, 1996. ,
Membrane Signaling Induced by High Doses of Ionizing Radiation in the Endothelial Compartment. Relevance in Radiation Toxicity, International Journal of Molecular Sciences, vol.14, issue.11, pp.22678-22696, 2013. ,
DOI : 10.3390/ijms141122678
Oxidative Stress, Antioxidants, and Endothelial Function, Current Medicinal Chemistry, vol.11, issue.9, pp.1093-1104, 2004. ,
DOI : 10.2174/0929867043365369
Oxidative Stress, Endothelial Dysfunction and Atherosclerosis, Current Pharmaceutical Design, vol.15, issue.26, pp.2988-3002, 2009. ,
DOI : 10.2174/138161209789058093
URL : http://doi.org/10.2174/138161209789058093
Role of polyphenols in improving endothelial dysfunction in diabetes, Free Radic, Biol. Med, vol.75, pp.11-12, 2014. ,
Mechanisms of lung endothelial barrier disruption induced by cigarette smoke: role of oxidative stress and ceramides, American Journal of Physiology - Lung Cellular and Molecular Physiology, vol.301, issue.6, pp.836-846, 2011. ,
DOI : 10.1152/ajplung.00385.2010
p38 MAP kinase-dependent regulation of endothelial cell permeability, AJP: Lung Cellular and Molecular Physiology, vol.287, issue.5, pp.911-918, 2004. ,
DOI : 10.1152/ajplung.00372.2003
Modulation of Radiation Injury Response in Retinal Endothelial Cells by Quinic Acid Derivative KZ-41 Involves p38 MAPK, PLoS ONE, vol.15, issue.6, p.100210, 2014. ,
DOI : 10.1371/journal.pone.0100210.g009
p38 MAPK mediates gamma-irradiation-induced endothelial cell apoptosis, and vascular endothelial growth factor protects endothelial cells through the phosphoinositide 3-kinase-Akt-Bcl-2 pathway, J. Biol. Chem, issue.41, pp.279-43352, 2004. ,
Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SirT1 axis, Journal of Endocrinological Investigation, vol.13, issue.1, pp.411-422, 2016. ,
DOI : 10.1007/s40618-015-0381-9
Oxidative stress disassembles the p38/NPM/PP2A complex, which leads to modulation of nucleophosmin-mediated signaling to DNA damage response, The FASEB Journal, vol.30, issue.8, 2016. ,
DOI : 10.1096/fj.201500194R
URL : https://hal.archives-ouvertes.fr/inserm-01312779
Human vascular endothelial cells are a rich and regulatable source of se cretory sphingomyelinase. Implications for early atherogenesis and ceramide-mediated cell signaling, J. Biol. Chem, issue.7, pp.273-4081, 1998. ,
Sphingosine-1-Phosphate Activates the AKT Pathway to Protect Small Intestines from Radiation-Induced Endothelial Apoptosis, Cancer Research, vol.70, issue.23, pp.9905-9915, 2010. ,
DOI : 10.1158/0008-5472.CAN-10-2043
Sphingosine-1-Phosphate Protects Proliferating Endothelial Cells from Ceramide-Induced Apoptosis but not from DNA Damage-Induced Mitotic Death, Cancer Research, vol.67, issue.4, pp.1803-1811, 2007. ,
DOI : 10.1158/0008-5472.CAN-06-2802
Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice, Science, vol.293, issue.5528, pp.293-297, 2001. ,
DOI : 10.1126/science.1060191
Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis, Science, vol.300, issue.5622, pp.1155-1159, 2003. ,
DOI : 10.1126/science.1082504
Adenoviral Transduction of Human Acid Sphingomyelinase into Neo-Angiogenic Endothelium Radiosensitizes Tumor Cure, PLoS ONE, vol.112, issue.8, p.69025, 2013. ,
DOI : 10.1371/journal.pone.0069025.s006
Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice, Journal of Clinical Investigation, vol.122, issue.5, pp.1786-1790, 2012. ,
DOI : 10.1172/JCI59920DS1
Lipid Rafts and Redox Signaling, Antioxidants & Redox Signaling, vol.9, issue.9, pp.1411-1415, 2007. ,
DOI : 10.1089/ars.2007.1736
Differential Activation of Acid Sphingomyelinase and Ceramide Release Determines Invasiveness of Neisseria meningitidis into Brain Endothelial Cells, PLoS Pathogens, vol.337, issue.6, p.1004160, 2014. ,
DOI : 10.1371/journal.ppat.1004160.s007
Thrombin stimulates albumin transcytosis in lung microvascular endothelial cells via activation of acid sphingomyelinase, American Journal of Physiology - Lung Cellular and Molecular Physiology, issue.8, pp.310-720, 2016. ,
DOI : 10.1152/ajplung.00157.2015
Acid Sphingomyelinase Promotes Endothelial Stress Response in Systemic Inflammation and Sepsis, Molecular Medicine, vol.22, issue.1, p.22, 2016. ,
DOI : 10.2119/molmed.2016.00140
URL : http://doi.org/10.2119/molmed.2016.00140
The structural requirements for ceramide activation of serine-threonine protein phosphatases, The Journal of Lipid Research, vol.45, issue.3, pp.496-506, 2004. ,
DOI : 10.1194/jlr.M300347-JLR200
Ceramide: A simple sphingolipid with unique biophysical properties, Progress in Lipid Research, vol.54, pp.53-67, 2014. ,
DOI : 10.1016/j.plipres.2014.01.004
Ceramide-enriched membrane domains???Structure and function, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1788, issue.1, pp.178-183, 2009. ,
DOI : 10.1016/j.bbamem.2008.07.030
URL : http://doi.org/10.1016/j.bbamem.2008.07.030
Raft ceramide in molecular medicine, Oncogene, vol.22, issue.45, pp.7070-7077, 2003. ,
DOI : 10.1038/sj.onc.1207146
Lysosomal Targeting and Trafficking of Acid Sphingomyelinase to Lipid Raft Platforms in Coronary Endothelial Cells, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.28, issue.11, pp.2056-2062, 2008. ,
DOI : 10.1161/ATVBAHA.108.172478
Lipid rafts regulate cellular CD40 receptor localization in vascular endothelial cells, Biochemical and Biophysical Research Communications, vol.361, issue.3, pp.361-768, 2007. ,
DOI : 10.1016/j.bbrc.2007.07.102
TNF-?? potentiates protein-tyrosine nitration through activation of NADPH oxidase and eNOS localized in membrane rafts and caveolae of bovine aortic endothelial cells, AJP: Heart and Circulatory Physiology, vol.292, issue.2, pp.954-962, 2007. ,
DOI : 10.1152/ajpheart.00758.2006
Visfatin-induced lipid raft redox signaling platforms and dysfunction in glomerular endothelial cells, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol.1801, issue.12, pp.1294-1304, 2010. ,
DOI : 10.1016/j.bbalip.2010.09.001
Endostatin Associates with Lipid Rafts and Induces Reorganization of the Actin Cytoskeleton via Down-regulation of RhoA Activity, Journal of Biological Chemistry, vol.278, issue.39, pp.37895-37901, 2003. ,
DOI : 10.1074/jbc.M303569200
Formation of lipid raft redox signalling platforms in glomerular endothelial cells: an early event of homocysteine-induced glomerular injury, Journal of Cellular and Molecular Medicine, vol.19, issue.9b, pp.13-3303, 2009. ,
DOI : 10.1111/j.1582-4934.2009.00743.x
Shiga toxin glycosphingolipid receptors in microvascular and macrovascular endothelial cells: differential association with membrane lipid raft microdomains, The Journal of Lipid Research, vol.52, issue.4, pp.618-634, 2011. ,
DOI : 10.1194/jlr.M010819
Hu- man immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway, J. Virol, issue.13, pp.76-6689, 2002. ,
Membrane raft redox signalosomes in endothelial cells, Free Radical Research, vol.43, issue.8, pp.831-842, 2010. ,
DOI : 10.1161/01.CIR.0000115644.35804.8B
TRAIL death receptor 4 signaling via lysosome fusion and membrane raft clustering in coronary arterial endothelial cells: evidence from ASM knockout mice, Journal of Molecular Medicine, vol.46, issue.1, pp.25-36, 2013. ,
DOI : 10.1007/s00109-012-0968-y
Acid Sphingomyelinase and Its Redox Amplification in Formation of Lipid Raft Redox Signaling Platforms in Endothelial Cells, Antioxidants & Redox Signaling, vol.9, issue.7, pp.817-828, 2007. ,
DOI : 10.1089/ars.2007.1509
Hypoxia induces apoptosis of HUVECs in an in vitro capillary model by activating proapoptotic signal p38 through suppression of ERK1/2, Cellular Signalling, vol.19, issue.6, pp.1121-1131, 2007. ,
DOI : 10.1016/j.cellsig.2006.12.004
Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53, Oncogene, vol.54, issue.46, pp.6653-6664, 2007. ,
DOI : 10.1074/jbc.M502974200
The Antiapoptotic Effect of Heme Oxygenase-1 in Endothelial Cells Involves the Degradation of p38?? MAPK Isoform, The Journal of Immunology, vol.177, issue.3, pp.1894-1903, 2006. ,
DOI : 10.4049/jimmunol.177.3.1894
Reactive nitrogen and oxygen species activate different sphingomyelinases to induce apoptosis in airway epithelial cells, Experimental Cell Research, vol.313, issue.12, pp.2680-2686, 2007. ,
DOI : 10.1016/j.yexcr.2007.04.002
RhoA GTPase regulates radiation-induced alterations in endothelial cell adhesion and migration, Biochemical and Biophysical Research Communications, vol.414, issue.4, pp.750-755, 2011. ,
DOI : 10.1016/j.bbrc.2011.09.150
Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelin, J. Biol. Chem, vol.265, issue.25, pp.14917-14921, 1990. ,
Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): A Novel Pharmacological Group of Drugs with Broad Clinical Applications, Cellular Physiology and Biochemistry, vol.26, issue.1, pp.9-20, 2010. ,
DOI : 10.1159/000315101
TAO kinases mediate activation of p38 in response to DNA damage, The EMBO Journal, vol.4, issue.8, pp.2005-2014, 2007. ,
DOI : 10.1038/sj.emboj.7601668
p53-Deficient Cells Rely on ATM- and ATR-Mediated Checkpoint Signaling through the p38MAPK/MK2 Pathway for Survival after DNA Damage, Cancer Cell, vol.11, issue.2, pp.175-189, 2007. ,
DOI : 10.1016/j.ccr.2006.11.024
Ceramide-rich platforms in transmembrane signaling, FEBS Letters, vol.11, issue.9, pp.1728-1740, 2010. ,
DOI : 10.1016/j.febslet.2010.02.026
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440589
Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis, Journal of Experimental Medicine, vol.180, issue.2, pp.525-535, 1994. ,
DOI : 10.1084/jem.180.2.525
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191598
Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation, European Journal of Neuroscience, vol.275, issue.11, pp.13-2037, 2001. ,
DOI : 10.1006/excr.2000.4939
Activation of p38 Mitogen-Activated Protein Kinase and Caspases in UVB-Induced Apoptosis of Human Keratinocyte HaCaT Cells, Journal of Investigative Dermatology, vol.112, issue.5, pp.769-774, 1999. ,
DOI : 10.1046/j.1523-1747.1999.00582.x
Fas- or Ceramide-induced Apoptosis Is Mediated by a Rac1-regulated Activation of Jun N-terminal Kinase/p38 Kinases and GADD153, Journal of Biological Chemistry, vol.272, issue.35, pp.272-22173, 1997. ,
DOI : 10.1074/jbc.272.35.22173
Radioresistance of human carcinoma cells is correlated to a defect in raft membrane clustering, Free Radic, Biol. Med, vol.43, issue.5, pp.681-694, 2007. ,
Localized Irradiation of Cell Membrane by Auger Electrons Is Cytotoxic Through Oxidative Stress-Mediated Nontargeted Effects, Antioxidants & Redox Signaling, vol.25, issue.8, 2016. ,
DOI : 10.1089/ars.2015.6309
Mechanisms and functions of p38 MAPK signalling, Biochemical Journal, vol.180, issue.3, pp.403-417, 2010. ,
DOI : 10.2174/138161209788682299
Regulation of Rac1 translocation and activation by membrane domains and their boundaries, Journal of Cell Science, vol.127, issue.11, pp.2565-2576, 2014. ,
DOI : 10.1242/jcs.149088
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1, The EMBO Journal, vol.17, issue.9, pp.2596-2606, 1998. ,
DOI : 10.1093/emboj/17.9.2596
Activation of Human Acid Sphingomyelinase through Modification or Deletion of C-terminal Cysteine, Journal of Biological Chemistry, vol.278, issue.35, pp.278-32744, 2003. ,
DOI : 10.1074/jbc.M303022200
Anisomycin uses multiple mechanisms to stimulate mitogen-activated protein kinases and gene expression and to inhibit neuronal differentiation in PC12 phaeochromocytoma cells, European Journal of Neuroscience, vol.94, issue.2, pp.527-532, 2000. ,
DOI : 10.1046/j.1460-9568.2000.00933.x
p38 MAPK downregulates phosphorylation of Bad in doxorubicin-induced endothelial apoptosis, Biochemical and Biophysical Research Communications, vol.347, issue.3, pp.781-790, 2006. ,
DOI : 10.1016/j.bbrc.2006.06.159
Effects of p38 and p42/p44 CCDPK signaling on H 2 O 2 -induced apoptosis in bovine aortic endothelial cells, Acta Pharmacol. Sin, vol.21, issue.11, pp.991-996, 2000. ,
Pathological neoangiogenesis depends on oxidative stress regulation by ATM, Nat. Med, vol.18, issue.8, pp.1208-1216, 2012. ,
Attenuation by Statins of Membrane Raft-Redox Signaling in Coronary Arterial Endothelium, Journal of Pharmacology and Experimental Therapeutics, vol.345, issue.2, pp.170-179, 2013. ,
DOI : 10.1124/jpet.112.201442
Statins and the vascular endothelial inflammatory response, Trends in Immunology, vol.28, issue.2, pp.88-98, 2007. ,
DOI : 10.1016/j.it.2006.12.003
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839264
Pravastatin limits radiation-induced vascular dysfunction in the skin, J. Invest. Dermatol, vol.129, issue.5, pp.1280-1291, 2009. ,