Z. Chen, C. Fillmore, P. Hammerman, C. Kim, and K. Wong, Non-small-cell lung cancers: a heterogeneous set of diseases, Nature Reviews Cancer, vol.8, issue.8, pp.535-581, 2014.
DOI : 10.1038/nrc3775

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers et al., Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012, International Journal of Cancer, vol.13, issue.5, pp.359-86, 2015.
DOI : 10.1002/ijc.29210

D. Ettinger, NCCN guidelines insights: Non-small cell lung cancer, version 4.2016, J Natl Compr Canc Netw, vol.14, pp.255-64, 2016.

S. Coughlin, Thrombin signalling and protease-activated receptors, Nature, vol.407, issue.6801, pp.258-64, 2000.
DOI : 10.1038/35025229

T. Vu, D. Hung, V. Wheaton, and S. Coughlin, Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation, Cell, vol.64, issue.6, pp.1057-68, 1991.
DOI : 10.1016/0092-8674(91)90261-V

A. Boire, L. Covic, A. Agarwal, S. Jacques, S. Sherifi et al., PAR1 Is a Matrix Metalloprotease-1 Receptor that Promotes Invasion and Tumorigenesis of Breast Cancer Cells, Cell, vol.120, issue.3, pp.303-316, 2005.
DOI : 10.1016/j.cell.2004.12.018

S. Grisaru-granovsky, Z. Salah, M. Maoz, D. Pruss, U. Beller et al., Differential expression ofProtease activated receptor 1 (Par1) and pY397FAK in benign and malignant human ovarian tissue samples, International Journal of Cancer, vol.160, issue.3, pp.372-380, 2005.
DOI : 10.1002/ijc.20607

D. Massi, A. Naldini, C. Ardinghi, F. Carraro, A. Franchi et al., Expression of protease-activated receptors 1 and 2 in melanocytic nevi and malignant melanoma, Human Pathology, vol.36, issue.6, pp.676-85, 2005.
DOI : 10.1016/j.humpath.2005.04.008

P. Black, G. Mize, P. Karlin, D. Greenberg, S. Hawley et al., Overexpression of protease-activated receptors-1,-2, and-4 (PAR-1, -2, and -4) in prostate cancer, The Prostate, vol.59, issue.7, pp.743-56, 2007.
DOI : 10.1002/pros.20503

J. Cisowski, O. Callaghan, K. Kuliopulos, A. Yang, J. Nguyen et al., Targeting Protease-Activated Receptor-1 with Cell-Penetrating Pepducins in Lung Cancer, The American Journal of Pathology, vol.179, issue.1, pp.513-536, 2011.
DOI : 10.1016/j.ajpath.2011.03.025

D. Fujimoto, Y. Hirono, T. Goi, K. Katayama, and A. Yamaguchi, Prognostic value of protease-activated receptor-1 (PAR-1) and matrix metalloproteinase-1 (MMP- 1) in gastric cancer, Anticancer Res, vol.28, pp.847-54, 2008.

G. Villares, M. Zigler, H. Wang, V. Melnikova, H. Wu et al., Targeting Melanoma Growth and Metastasis with Systemic Delivery of Liposome-Incorporated Protease-Activated Receptor-1 Small Interfering RNA, Cancer Research, vol.68, issue.21, pp.9078-86, 2008.
DOI : 10.1158/0008-5472.CAN-08-2397

M. Zigler, T. Kamiya, E. Brantley, G. Villares, and M. Bar-eli, PAR-1 and Thrombin: The Ties That Bind the Microenvironment to Melanoma Metastasis, Cancer Research, vol.71, issue.21, pp.6561-6567, 2011.
DOI : 10.1158/0008-5472.CAN-11-1432

M. Reck, D. Heigener, T. Mok, J. Soria, and K. Rabe, Management of non-small-cell lung cancer: recent developments, The Lancet, vol.382, issue.9893, pp.709-728, 2013.
DOI : 10.1016/S0140-6736(13)61502-0

N. El-nikhely, L. Larzabal, W. Seeger, A. Calvo, and R. Savai, Tumor???stromal interactions in lung cancer: novel candidate targets for therapeutic intervention, Expert Opinion on Investigational Drugs, vol.9, issue.8, pp.1107-1129, 2012.
DOI : 10.1158/1078-0432.CCR-10-2805

D. Quail and J. Joyce, Microenvironmental regulation of tumor progression and metastasis, Nature Medicine, vol.87, issue.11, pp.1423-1460, 2013.
DOI : 10.1016/j.ccr.2013.02.013

G. Adams, L. Rosenfeldt, M. Frederick, W. Miller, D. Waltz et al., Colon Cancer Growth and Dissemination Relies upon Thrombin, Stromal PAR-1, and Fibrinogen, Cancer Research, vol.75, issue.19, pp.4235-4278, 2015.
DOI : 10.1158/0008-5472.CAN-15-0964

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809049

K. Queiroz, K. Shi, J. Duitman, H. Aberson, J. Wilmink et al., Protease-activated receptor-1 drives pancreatic cancer progression and chemoresistance, International Journal of Cancer, vol.11, issue.Suppl 1, pp.2294-304, 2014.
DOI : 10.1002/ijc.28726

J. Weinstein, A. Lau, L. Brass, and D. Cunningham, Injury-Related Factors and Conditions Down-Regulate the Thrombin Receptor (PAR-1) in a Human Neuronal Cell Line, Journal of Neurochemistry, vol.71, issue.3, pp.1034-50, 1998.
DOI : 10.1046/j.1471-4159.1998.71031034.x

O. Brien, P. Prevost, N. Molino, M. Hollinger, M. Woolkalis et al., Thrombin Responses in Human Endothelial Cells. CONTRIBUTIONS FROM RECEPTORS OTHER THAN PAR1 INCLUDE THE TRANSACTIVATION OF PAR2 BY THROMBIN-CLEAVED PAR1, Journal of Biological Chemistry, vol.275, issue.18, pp.13502-13511, 2000.
DOI : 10.1074/jbc.275.18.13502

S. Lau, P. Chu, and L. Weiss, CD163, American Journal of Clinical Pathology, vol.122, issue.5, pp.794-801, 2004.
DOI : 10.1309/QHD6YFN81KQXUUH6

J. Tomasek, G. Gabbiani, B. Hinz, C. Chaponnier, and R. Brown, Myofibroblasts and mechano-regulation of connective tissue remodelling, Nature Reviews Molecular Cell Biology, vol.3, issue.5, pp.349-63, 2002.
DOI : 10.1038/nrm809

D. Andrea, M. Derian, C. Santulli, R. Andrade-gordon, and P. , Differential expression of protease-activated receptors-1 and ?2 in stromal fibroblasts of normal, benign, and malignant human tissues, Am J Pathol, vol.158, pp.2031-2072, 2001.

X. Zhang, W. Wang, L. True, R. Vessella, and T. Takayama, Protease-activated receptor-1 is upregulated in reactive stroma of primary prostate cancer and bone metastasis, The Prostate, vol.166, issue.7, pp.727-763, 2009.
DOI : 10.1002/pros.20920

W. Wang, G. Mize, X. Zhang, and T. Takayama, Kallikrein-related peptidase-4 initiates tumor??????stroma interactions in prostate cancer through protease-activated receptor-1, International Journal of Cancer, vol.121, issue.3, pp.599-610, 2010.
DOI : 10.1002/ijc.24904

E. Jin, M. Fujiwara, X. Pan, M. Ghazizadeh, S. Arai et al., Protease-activated receptor (PAR)-1 and PAR-2 participate in the cell growth of alveolar capillary endothelium in primary lung adenocarcinomas, Cancer, vol.28, issue.3, pp.703-716, 2003.
DOI : 10.1002/cncr.11087

C. Lin, F. Rezaee, M. Waasdorp, K. Shi, T. Van-der-poll et al., Protease activated receptor-1 regulates macrophage-mediated cellular senescence: a risk for idiopathic pulmonary fibrosis, Oncotarget, vol.6, pp.35304-35318, 2015.

D. Howell, R. Johns, J. Lasky, B. Shan, C. Scotton et al., Absence of Proteinase-Activated Receptor-1 Signaling Affords Protection from Bleomycin-Induced Lung Inflammation and Fibrosis, The American Journal of Pathology, vol.166, issue.5, pp.1353-65, 2005.
DOI : 10.1016/S0002-9440(10)62354-1

C. Lin, J. Duitman, J. Daalhuisen, T. Brink, M. et al., Targeting protease activated receptor-1 with P1pal-12 limits bleomycin-induced pulmonary fibrosis, Thorax, vol.25, issue.2, pp.152-60, 2014.
DOI : 10.1136/thoraxjnl-2013-203877

Z. Wu, Y. Zeng, M. Zhong, and B. Wang, Targeting A549 lung adenocarcinoma cell growth and invasion with protease???activated receptor???1 siRNA, Molecular Medicine Reports, vol.9, pp.1787-93, 2014.
DOI : 10.3892/mmr.2014.2023

J. Tchou and J. Conejo-garcia, Targeting the Tumor Stroma as a Novel Treatment Strategy for Breast Cancer, Adv Pharmacol, vol.65, pp.45-61, 2012.
DOI : 10.1016/B978-0-12-397927-8.00003-8

K. Olive, M. Jacobetz, C. Davidson, A. Gopinathan, D. Mcintyre et al., Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer, Science, vol.324, issue.5933, pp.1457-61, 2009.
DOI : 10.1126/science.1171362

M. Lopez, A. Rivera, D. Viale, L. Benedetti, N. Cuneo et al., A Tumor-stroma Targeted Oncolytic Adenovirus Replicated in Human Ovary Cancer Samples and Inhibited Growth of Disseminated Solid Tumors in Mice, Molecular Therapy, vol.20, issue.12, pp.2222-2255, 2012.
DOI : 10.1038/mt.2012.147

K. Erturk, D. Tastekin, E. Bilgin, F. Tas, R. Disci et al., Clinical significance of serum protease activated receptor1 levels in patients with lung cancer, Eur Rev Med Pharmacol Sci, vol.20, pp.243-252, 2016.

P. Ghio, S. Cappia, G. Selvaggi, S. Novello, P. Lausi et al., Prognostic Role of Protease-Activated Receptors 1 and 4 in Resected Stage IB Non-Small-Cell Lung Cancer, Clinical Lung Cancer, vol.7, issue.6, pp.395-400, 2006.
DOI : 10.3816/CLC.2006.n.023

E. De-meis, D. Azambuja, J. Ayres-silva, M. Zamboni, V. Pinheiro et al., Increased expression of tissue factor and protease-activated receptor-1 does not correlate with thrombosis in human lung adenocarcinoma, Brazilian Journal of Medical and Biological Research, vol.43, issue.4, pp.403-411, 2010.
DOI : 10.1590/S0100-879X2010007500017