Deforestation-driven food-web collapse linked to emerging tropical infectious disease, Mycobacterium ulcerans

Abstract : Generalist microorganisms are the agents of many emerging infectious diseases (EIDs), but their natural life cycles are difficult to predict due to the multiplicity of potential hosts and environmental reservoirs. Among 250 known human EIDs, many have been traced to tropical rain forests and specifically freshwater aquatic systems, which act as an interface between microbe-rich sediments or substrates and terrestrial habitats. Along with the rapid urbanization of developing countries, population encroachment, deforestation, and land-use modifications are expected to increase the risk of EID outbreaks. We show that the freshwater food-web collapse driven by land-use change has a nonlinear effect on the abundance of preferential hosts of a generalist bacterial pathogen, Mycobacterium ulcerans. This leads to an increase of the pathogen within systems at certain levels of environmental disturbance. The complex link between aquatic, terrestrial, and EID processes highlights the potential importance of species community composition and structure and species life history traits in disease risk estimation and mapping. Mechanisms such as the one shown here are also central in predicting how human-induced environmental change, for example, deforestation and changes in land use, may drive emergence.
Type de document :
Article dans une revue
Science Advances , American Association for the Advancement of Science (AAAS), 2016, 2 (12), pp.e1600387. 〈10.1126/sciadv.1600387〉
Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-01421033
Contributeur : Elizabeth Bernardo <>
Soumis le : mercredi 21 décembre 2016 - 14:17:56
Dernière modification le : mardi 5 juin 2018 - 10:14:32
Document(s) archivé(s) le : mardi 21 mars 2017 - 02:25:42

Fichier

deforstationMarsollier2016.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Citation

Aaron Morris, Jean-François Guégan, Demetra Andreou, Laurent Marsollier, Kevin Carolan, et al.. Deforestation-driven food-web collapse linked to emerging tropical infectious disease, Mycobacterium ulcerans. Science Advances , American Association for the Advancement of Science (AAAS), 2016, 2 (12), pp.e1600387. 〈10.1126/sciadv.1600387〉. 〈inserm-01421033〉

Partager

Métriques

Consultations de la notice

144

Téléchargements de fichiers

274