J. Capeau, J. Magré, M. Caron-debarle, and C. Lagathu, Human Lipodystrophies: Genetic and Acquired Diseases of Adipose Tissue, Endocr Dev, vol.19, pp.1-20, 2010.
DOI : 10.1159/000316893

URL : https://hal.archives-ouvertes.fr/inserm-00848148

A. Garg, Lipodystrophies: Genetic and Acquired Body Fat Disorders, The Journal of Clinical Endocrinology & Metabolism, vol.96, issue.11, pp.3313-3325, 2011.
DOI : 10.1210/jc.2011-1159

J. Magré, M. Delépine, E. Khallouf, and T. J. Gedde-dahl, Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13, Nature Genetics, vol.28, issue.4, pp.365-370, 2001.
DOI : 10.1038/ng585

W. Chen, V. K. Yechoor, B. H. Chang, and M. V. Li, The Human Lipodystrophy Gene Product Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Plays a Key Role in Adipocyte Differentiation, Endocrinology, vol.150, issue.10, pp.4552-4561, 2009.
DOI : 10.1210/en.2009-0236

V. A. Payne, N. Grimsey, A. Tuthill, and S. Virtue, The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation, Diabetes, vol.57, issue.8, pp.2055-2060, 2008.
DOI : 10.2337/db08-0184

W. Fei, G. Shui, B. Gaeta, and X. Du, Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast, The Journal of Cell Biology, vol.13, issue.3, pp.473-482, 2008.
DOI : 10.1046/j.1432-1327.2000.01103.x

K. M. Szymanski, D. Binns, R. Bartz, and N. V. Grishin, The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology, Proceedings of the National Academy of Sciences, vol.104, issue.52, pp.20890-20895, 2007.
DOI : 10.1073/pnas.0704154104

W. Fei, G. Shui, Y. Zhang, and N. Krahmer, A Role for Phosphatidic Acid in the Formation of ???Supersized??? Lipid Droplets, PLoS Genetics, vol.121, issue.7, p.1002201, 2011.
DOI : 10.1371/journal.pgen.1002201.s008

E. Boutet, H. Mourabit, M. Prot, and M. Nemani, Seipin deficiency alters fatty acid ??9 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophy, Biochimie, vol.91, issue.6, pp.796-803, 2009.
DOI : 10.1016/j.biochi.2009.01.011

B. R. Cartwright, D. D. Binns, C. L. Hilton, and S. Han, Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology, Molecular Biology of the Cell, vol.26, issue.4, pp.726-739, 2015.
DOI : 10.1091/mbc.E14-08-1303

M. F. Sim, M. U. Talukder, R. J. Dennis, J. M. Edwardson, and J. J. Rochford, Analyzing the Functions and Structure of the Human Lipodystrophy Protein Seipin, Methods Enzymol, vol.537, pp.161-175, 2014.
DOI : 10.1016/B978-0-12-411619-1.00009-4

M. M. Talukder, M. F. Sim, S. O-'rahilly, J. M. Edwardson, and J. J. Rochford, Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis, Molecular Metabolism, vol.4, issue.3, pp.199-209, 2015.
DOI : 10.1016/j.molmet.2014.12.013

J. Bi, W. Wang, Z. Liu, and X. Huang, Seipin Promotes Adipose Tissue Fat Storage through the ER Ca2+-ATPase SERCA, Cell Metabolism, vol.19, issue.5, pp.861-871, 2014.
DOI : 10.1016/j.cmet.2014.03.028

X. Cui, Y. Wang, Y. Tang, and Y. Liu, Seipin ablation in mice results in severe generalized lipodystrophy, Human Molecular Genetics, vol.20, issue.15, pp.3022-3030, 2011.
DOI : 10.1093/hmg/ddr205

URL : http://hmg.oxfordjournals.org/cgi/content/short/20/15/3022

W. Chen, B. Chang, P. Saha, and S. M. Hartig, Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is a Cell-Autonomous Regulator of Lipolysis Essential for Adipocyte Differentiation, Molecular and Cellular Biology, vol.32, issue.6, pp.1099-1111, 2012.
DOI : 10.1128/MCB.06465-11

X. Prieur, L. Dollet, M. Takahashi, and M. Nemani, Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice, Diabetologia, vol.162, issue.8, pp.1813-1825, 2013.
DOI : 10.1007/s00125-013-2926-9

L. Liu, Q. Jiang, X. Wang, and Y. Zhang, Adipose-Specific Knockout of Seipin/Bscl2 Results in Progressive Lipodystrophy, Diabetes, vol.63, issue.7, 2014.
DOI : 10.2337/db13-0729

M. Gao, M. Wang, X. Guo, and X. Qiu, Expression of seipin in adipose tissue rescues lipodystrophy, hepatic steatosis and insulin resistance in seipin null mice, Biochemical and Biophysical Research Communications, vol.460, issue.2, pp.143-150, 2015.
DOI : 10.1016/j.bbrc.2015.02.147

W. Chen, H. Zhou, S. Liu, and C. J. Fhaner, Altered Lipid Metabolism in Residual White Adipose Tissues of Bscl2 Deficient Mice, PLoS ONE, vol.2, issue.12, p.82526, 2013.
DOI : 10.1371/journal.pone.0082526.s001

S. Virtue and A. Vidal-puig, Assessment of brown adipose tissue function, Frontiers in Physiology, vol.4, p.128, 2013.
DOI : 10.3389/fphys.2013.00128

G. P. Webb, S. A. Jagot, and M. E. Jakobson, Fasting-induced torpor in Mus musculus and its implications in the use of murine models for human obesity studies, Comparative Biochemistry and Physiology Part A: Physiology, vol.72, issue.1, pp.211-219, 1982.
DOI : 10.1016/0300-9629(82)90035-4

B. Cannon and J. Nedergaard, Brown Adipose Tissue: Function and Physiological Significance, Physiological Reviews, vol.84, issue.1, pp.277-359, 2004.
DOI : 10.1152/physrev.00015.2003

H. Zhou, S. M. Black, T. W. Benson, N. L. Weintraub, and W. Chen, Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is Not Required for Brown Adipogenesis but Regulates Brown Adipose Tissue Development and Function, Molecular and Cellular Biology, vol.36, issue.15, pp.2027-2038, 2016.
DOI : 10.1128/MCB.01120-15

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946430

V. Peirce, S. Carobbio, and A. Vidal-puig, The different shades of fat, Nature, vol.123, issue.7503, pp.76-83, 2014.
DOI : 10.1038/nature13477

L. Dollet, J. Magré, B. Cariou, and X. Prieur, Function of seipin: New insights from Bscl2/seipin knockout mouse models, Biochimie, vol.96, pp.166-172, 2014.
DOI : 10.1016/j.biochi.2013.06.022

C. Ebihara, K. Ebihara, M. Aizawa-abe, and T. Mashimo, Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis, Human Molecular Genetics, vol.24, issue.15, 2015.
DOI : 10.1093/hmg/ddv156

P. J. Scarpace and M. Matheny, Leptin induction of UCP1 gene expression is dependent on sympathetic innervation, Am J Physiol, vol.275, pp.259-264, 1998.

B. Cariou, E. Bouchaert, M. Abdelkarim, and J. Dumont, FXR-deficiency confers increased susceptibility to torpor, FEBS Letters, vol.70, issue.27, pp.5191-5198, 2007.
DOI : 10.1016/j.febslet.2007.09.064

URL : https://hal.archives-ouvertes.fr/inserm-00409558

I. W. Asterholm and P. Scherer, Enhanced Metabolic Flexibility Associated with Elevated Adiponectin Levels, The American Journal of Pathology, vol.176, issue.3, pp.1364-1376, 2010.
DOI : 10.2353/ajpath.2010.090647

C. Guerra, P. Navarro, A. M. Valverde, and M. Arribas, Brown adipose tissue???specific insulin receptor knockout shows diabetic phenotype without insulin resistance, Journal of Clinical Investigation, vol.108, issue.8, pp.1205-1213, 2001.
DOI : 10.1172/JCI13103

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC209529

S. W. Mercer and P. Trayhurn, Effects of ciglitazone on insulin resistance and thermogenic responsiveness to acute cold in brown adipose tissue of genetically obese (ob/ob) mice, FEBS Letters, vol.94, issue.1-2, pp.12-16, 1986.
DOI : 10.1016/0014-5793(86)80120-X

A. Whittle, J. Relat-pardo, and A. Vidal-puig, Pharmacological strategies for targeting BAT thermogenesis, Trends in Pharmacological Sciences, vol.34, issue.6, pp.347-355, 2013.
DOI : 10.1016/j.tips.2013.04.004

W. Chen, H. Zhou, P. Saha, L. Li, and L. Chan, /Seipin-Deficient Mice, Endocrinology, vol.155, issue.11, pp.4215-4225, 2014.
DOI : 10.1210/en.2014-1292

Y. Tian, J. Bi, G. Shui, and Z. Liu, Tissue-Autonomous Function of Drosophila Seipin in Preventing Ectopic Lipid Droplet Formation, PLoS Genetics, vol.6, issue.4, p.1001364, 2011.
DOI : 10.1371/journal.pgen.1001364.s008