Postow reports receiving honoraria from Bristol-Myers Squibb and Merck, and is a consultant/advisory board member for and reports receiving commercial research grants from ,
Ascierto is a consultant/advisory board member for Amgen, Array, Bristol-Myers Squibb, MSD, Novartis, Roche-Genentech, and Ventana, and reports receiving commercial research grants from Bristol-Myers Squibb, Roche-Genentech, and Ventana. J.D. Wolchok is a consultant/advisory board member for and reports receiving commercial research grants from Bristol-Myers Squibb and Medimmune. G. Pawelec reports receiving speakers bureau honoraria from Astellas, Cellgene, Clasado, and Pfizer. C. Garbe is a consultant/advisory board member for Amgen, and reports receiving commercial research grants from Bristol-Myers Squibb, Novartis, and Roche, and speakers bureau honoraria and travel reimbursement from Amgen Weide reports receiving commercial research grants, honoraria, and travel support from Bristol-Myers Squibb. No potential conflicts of interest were disclosed by the other authors ,
Weide Acquisition of data (provided animals, acquired and managed patients, provided facilities Weide Analysis and interpretation of data (e.g., statistical analysis, biostatistics, computational analysis Weide Administrative, technical, or material support (i.e., reporting or organizing data, N Engl J Med, vol.363, pp.711-734, 2010. ,
Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma, New England Journal of Medicine, vol.364, issue.26, pp.2517-2543, 2011. ,
DOI : 10.1056/NEJMoa1104621
Pooled Analysis of Long-Term Survival Data From Phase II and Phase III Trials of Ipilimumab in Unresectable or Metastatic Melanoma, Journal of Clinical Oncology, vol.33, issue.17, pp.1889-94, 2015. ,
DOI : 10.1200/JCO.2014.56.2736
Novel cancer immunotherapy agents with survival benefit: recent successes and next steps, Nature Reviews Cancer, vol.208, issue.11, pp.805-817, 2011. ,
DOI : 10.1038/nrc3153
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426440
Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib, New England Journal of Medicine, vol.372, issue.1, pp.30-39, 2015. ,
DOI : 10.1056/NEJMoa1412690
Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial, The Lancet, vol.384, issue.9948, pp.1109-1126, 2014. ,
DOI : 10.1016/S0140-6736(14)60958-2
Frequencies of circulating MDSC correlate with clinical outcome of melanoma patients treated with ipilimumab, Cancer Immunology, Immunotherapy, vol.60, issue.10, pp.247-57, 2014. ,
DOI : 10.1007/s00262-013-1508-5
Ipilimumab Treatment Results in an Early Decrease in the Frequency of Circulating Granulocytic Myeloid-Derived Suppressor Cells as well as Their Arginase1 Production, Cancer Immunology Research, vol.1, issue.3, pp.158-62, 2013. ,
DOI : 10.1158/2326-6066.CIR-13-0016
Computational Algorithm-Driven Evaluation of Monocytic Myeloid-Derived Suppressor Cell Frequency for Prediction of Clinical Outcomes, Cancer Immunology Research, vol.2, issue.8, pp.812-833, 2014. ,
DOI : 10.1158/2326-6066.CIR-14-0013
Immune Monitoring of the Circulation and the Tumor Microenvironment in Patients with Regionally Advanced Melanoma Receiving Neoadjuvant Ipilimumab, PLoS ONE, vol.72, issue.2, p.87705, 2014. ,
DOI : 10.1371/journal.pone.0087705.s007
Immunological and biological changes during ipilimumab treatment and their potential correlation with clinical response and survival in patients with advanced melanoma, Cancer Immunology, Immunotherapy, vol.60, issue.7, pp.675-83, 2014. ,
DOI : 10.1007/s00262-014-1545-8
Experience in daily practice with ipilimumab for the treatment of patients with metastatic melanoma: an early increase in lymphocyte and eosinophil counts is associated with improved survival, Annals of Oncology, vol.24, issue.6, pp.1697-703, 2013. ,
DOI : 10.1093/annonc/mdt027
Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting, Cancer, vol.27, issue.22 pt 1, pp.1767-75, 2010. ,
DOI : 10.1002/cncr.24951
Single-Center Experience With Ipilimumab in an Expanded Access Program for Patients With Pretreated Advanced Melanoma, Journal of Immunotherapy, vol.36, issue.3, pp.215-237, 2013. ,
DOI : 10.1097/CJI.0b013e31828eed39
Lactate dehydrogenase as a selection criterion for ipilimumab treatment in metastatic melanoma, Cancer Immunology, Immunotherapy, vol.369, issue.2, pp.449-58, 2014. ,
DOI : 10.1007/s00262-014-1528-9
Extended Dose Ipilimumab with a Peptide Vaccine: Immune Correlates Associated with Clinical Benefit in Patients with Resected High-Risk Stage IIIc/IV Melanoma, Clinical Cancer Research, vol.17, issue.4, pp.896-906, 2011. ,
DOI : 10.1158/1078-0432.CCR-10-2463
Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with Ipilimumab, Clinical Cancer Research, vol.21, issue.24, pp.5453-5462, 2015. ,
DOI : 10.1158/1078-0432.CCR-15-0676
Coordinated regulation of myeloid cells by tumours, Nature Reviews Immunology, vol.205, issue.4, pp.253-68, 2012. ,
DOI : 10.1038/nri3175
Myeloid-Derived Suppressor Cells Predict Survival of Patients with Advanced Melanoma: Comparison with Regulatory T Cells and NY-ESO-1- or Melan-A-Specific T Cells, Clinical Cancer Research, vol.20, issue.6, pp.1601-1610, 2014. ,
DOI : 10.1158/1078-0432.CCR-13-2508
Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival, Nature Medicine, vol.174, issue.8, pp.1254-61, 2012. ,
DOI : 10.1016/j.cll.2007.05.002
Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with Surrogate Markers for Ipilimumab-Treated Patients www significant elevation of the Th2 cytokine interleukin-13, aacrjournals.org Clin Cancer Res Cancer Immunol Immunother, vol.2260, pp.1419-1449, 2011. ,
Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor, Immunity, vol.30, issue.6, pp.899-911, 2009. ,
DOI : 10.1016/j.immuni.2009.03.019
Biomarkers on melanoma patient T Cells associated with ipilimumab treatment, Journal of Translational Medicine, vol.10, issue.1, p.146, 2012. ,
DOI : 10.1002/eji.200939261
Increased Frequency of ICOS+ CD4 T Cells as a Pharmacodynamic Biomarker for Anti-CTLA-4 Therapy, Cancer Immunology Research, vol.1, issue.4, pp.229-263, 2013. ,
DOI : 10.1158/2326-6066.CIR-13-0020
Long-term survival and immunological parameters in metastatic melanoma patients who responded to ipilimumab 10??mg/kg within an expanded access programme, Cancer Immunology, Immunotherapy, vol.91, issue.Suppl 7, pp.1021-1029, 2013. ,
DOI : 10.1007/s00262-013-1418-6
Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab, Clinical Cancer Research, vol.22, issue.12, 2016. ,
DOI : 10.1158/1078-0432.CCR-15-2412
URL : https://hal.archives-ouvertes.fr/inserm-01409624
Guidelines for the Evaluation of Immune Therapy Activity in Solid Tumors: Immune-Related Response Criteria, Clinical Cancer Research, vol.15, issue.23, pp.7412-7432, 2009. ,
DOI : 10.1158/1078-0432.CCR-09-1624
Ipilimumab treatment decreases circulating Tregs and GrMDSC while enhancing CD4+ T cell activation, Journal of Translational Medicine, vol.13, issue.Suppl 1, p.7, 2015. ,
DOI : 10.1186/1479-5876-13-S1-O7
Ipilimumab Increases Activated T Cells and Enhances Humoral Immunity in Patients With Advanced Melanoma, Journal of Immunotherapy, vol.35, issue.1, pp.89-97, 2012. ,
DOI : 10.1097/CJI.0b013e31823aa41c
Autoimmunity Correlates With Tumor Regression in Patients With Metastatic Melanoma Treated With Anti???Cytotoxic T-Lymphocyte Antigen-4, Journal of Clinical Oncology, vol.23, issue.25, pp.6043-53, 2005. ,
DOI : 10.1200/JCO.2005.06.205
Pharmacodynamic effect of ipilimumab on absolute lymphocyte count (ALC) and association with overall survival in patients with advanced melanoma, ASCO Meeting Abstracts, vol.31, p.9052, 2013. ,
Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab, Proceedings of the National Academy of Sciences, vol.108, issue.40, pp.16723-16731, 2011. ,
DOI : 10.1073/pnas.1110814108
CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit, Proceedings of the National Academy of Sciences, vol.105, issue.51, pp.20410-20415, 2008. ,
DOI : 10.1073/pnas.0810114105
Prognostic value of intratumoral natural killer cells in gastric carcinoma, Cancer, vol.88, issue.3, pp.577-83, 2000. ,
DOI : 10.1002/(SICI)1097-0142(20000201)88:3<577::AID-CNCR13>3.3.CO;2-M
The prognostic significance of intratumoral natural killer cells in patients with colorectal carcinoma, Cancer, vol.3, issue.12, pp.2320-2328, 1997. ,
DOI : 10.1002/(SICI)1097-0142(19970615)79:12<2320::AID-CNCR5>3.0.CO;2-P
Prognostic significance of tumor infiltrating natural killer cells subset CD57 in patients with squamous cell lung cancer, Lung Cancer, vol.35, issue.1, pp.23-31, 2002. ,
DOI : 10.1016/S0169-5002(01)00292-6
Identification and characterization of a tumor infiltrating CD56+/CD16??? NK cell subset with specificity for pancreatic and prostate cancer cell lines, Cancer Immunology, Immunotherapy, vol.214, issue.12, pp.1757-69, 2010. ,
DOI : 10.1007/s00262-010-0897-y
NK cells and CD8+ T cells cooperate to improve therapeutic responses in melanoma treated with interleukin-2 (IL-2) and CTLA-4 blockade, Journal for ImmunoTherapy of Cancer, vol.14, issue.5, p.18, 2015. ,
DOI : 10.1186/s40425-015-0063-3
The engagement of CTLA-4 on primary melanoma cell lines induces antibody-dependent cellular cytotoxicity and TNF-?? production, Journal of Translational Medicine, vol.11, issue.1, p.108, 2013. ,
DOI : 10.1007/s00262-005-0668-3
Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients, Proceedings of the National Academy of Sciences, vol.112, issue.19, pp.6140-6145, 2015. ,
DOI : 10.1073/pnas.1417320112
B Cells Are Required for Optimal CD4+ and CD8+ T Cell Tumor Immunity: Therapeutic B Cell Depletion Enhances B16 Melanoma Growth in Mice, The Journal of Immunology, vol.184, issue.7, pp.4006-4022, 2010. ,
DOI : 10.4049/jimmunol.0903009
CTLA-4 blockade increases IFN??-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients, Proceedings of the National Academy of Sciences, vol.105, issue.39, pp.14987-92, 2008. ,
DOI : 10.1073/pnas.0806075105
Anti-CTLA-4 therapy broadens the melanoma-reactive CD8þ T cell response, Sci Transl Med, vol.6, pp.254-128, 2014. ,
DOI : 10.1126/scitranslmed.3008918
Genomic correlates of response to CTLA-4 blockade in metastatic melanoma, Science, vol.350, issue.6257, pp.207-218, 2015. ,
DOI : 10.1126/science.aad0095
Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma, New England Journal of Medicine, vol.371, issue.23, pp.2189-99, 2014. ,
DOI : 10.1056/NEJMoa1406498
Pembrolizumab versus Ipilimumab in Advanced Melanoma, New England Journal of Medicine, vol.372, issue.26, pp.2521-2553, 2015. ,
DOI : 10.1056/NEJMoa1503093
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma, New England Journal of Medicine, vol.373, issue.1, pp.23-34, 2015. ,
DOI : 10.1056/NEJMoa1504030
URL : http://www.zora.uzh.ch/113016/1/608_Larkin%20et%20al%20_NEJM%202015.pdf
Myeloid-derived suppressor cell measurements in fresh and cryopreserved blood samples, Journal of Immunological Methods, vol.381, issue.1-2, pp.14-22, 2012. ,
DOI : 10.1016/j.jim.2012.04.004