The 2008 World Health Organization classification system for myeloproliferative neoplasms, Cancer, vol.22, issue.17, pp.3842-3847, 2009. ,
DOI : 10.1002/cncr.24440
Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22, Cell, vol.36, issue.1, pp.93-99, 1984. ,
DOI : 10.1016/0092-8674(84)90077-1
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera, Nature, vol.100, issue.7037, pp.1144-1148, 2005. ,
DOI : 10.1182/blood-2002-09-2839
in Myeloproliferative Disorders, New England Journal of Medicine, vol.352, issue.17, pp.1779-1790, 2005. ,
DOI : 10.1056/NEJMoa051113
MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia, PLoS Medicine, vol.102, issue.7, 2006. ,
DOI : 10.1371/journal.pmed.0030270.st001
Exon 12 Mutations in Polycythemia Vera and Idiopathic Erythrocytosis, New England Journal of Medicine, vol.356, issue.5, pp.459-468, 2007. ,
DOI : 10.1056/NEJMoa065202
Characterization of 35 new cases with four different MPLW515 mutations and essential thrombocytosis or primary myelofibrosis, Haematologica, vol.94, issue.1, pp.141-144, 2009. ,
DOI : 10.3324/haematol.13224
Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms, New England Journal of Medicine, vol.369, issue.25, pp.2379-2390, 2013. ,
DOI : 10.1056/NEJMoa1311347
The JAK2-V617F mutation is frequently present at diagnosis in patients with essential thrombocythemia and polycythemia vera, Blood, vol.108, issue.6, pp.1865-1867, 2006. ,
DOI : 10.1182/blood-2006-01-013540
JAK2 mutation and disease phenotype: a double L611V/V617F in cis mutation of JAK2 is associated with isolated erythrocytosis and increased activation of AKT and ERK1/2 rather than STAT5, Leukemia, vol.24, issue.5, pp.1069-1073, 2010. ,
DOI : 10.3324/haematol.13081
Molecular Pathways Linking Inflammation and Cancer, Current Molecular Medicine, vol.10, issue.4, pp.369-373, 2010. ,
DOI : 10.2174/156652410791316968
AG490 Promotes HIF-1α Accumulation by Inhibiting Its Hydroxylation, Current Medicinal Chemistry, vol.19, issue.23, pp.4014-4023, 2012. ,
DOI : 10.2174/092986712802002554
Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders, Blood, vol.108, issue.4, pp.1377-1380, 2006. ,
DOI : 10.1182/blood-2005-11-009605
Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms, Blood, vol.115, issue.10, pp.2003-2007, 2010. ,
DOI : 10.1182/blood-2009-09-245381
Homologous recombination of wild-type JAK2, a novel early step in the development of myeloproliferative neoplasm, Blood, vol.118, issue.24, pp.6468-6470, 2011. ,
DOI : 10.1182/blood-2011-08-372813
In essential thrombocythemia, multiple JAK2-V617F clones are present in most mutant-positive patients: a new disease paradigm, Blood, vol.114, issue.14, pp.3018-3023, 2009. ,
DOI : 10.1182/blood-2009-03-209916
Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms, Blood, vol.123, issue.14, pp.2220-2228, 2014. ,
DOI : 10.1182/blood-2013-11-537167
Perspectives on the impact of JAK-inhibitor therapy upon inflammation-mediated comorbidities in myelofibrosis and related neoplasms, Expert Review of Hematology, vol.7, issue.2, pp.203-216, 2014. ,
DOI : 10.1586/17474086.2013.876356
A Phase I/II Study of the Janus Kinase (JAK)1 and 2 Inhibitor Ruxolitinib in Patients With Relapsed or Refractory Acute Myeloid Leukemia, Clinical Lymphoma Myeloma and Leukemia, vol.15, issue.3, pp.171-176, 2015. ,
DOI : 10.1016/j.clml.2014.08.003
Cancer-related inflammation, Nature, vol.342, issue.7203, pp.436-444, 2008. ,
DOI : 10.1038/nature07205
Inflammation Versus Adaptive Immunity in Cancer Pathogenesis, Critical Reviews??? in Oncogenesis, vol.15, issue.1-2, pp.43-63, 2009. ,
DOI : 10.1615/CritRevOncog.v15.i1-2.20
Inflammation and cancer: advances and new agents, Nature Reviews Clinical Oncology, vol.11, issue.10, 2015. ,
DOI : 10.1038/nature07205
High-Altitude Illness, New England Journal of Medicine, vol.345, issue.2, pp.107-114, 2001. ,
DOI : 10.1056/NEJM200107123450206
HIGH ALTITUDE INCREASES CIRCULATING INTERLEUKIN-6, INTERLEUKIN-1 RECEPTOR ANTAGONIST AND C-REACTIVE PROTEIN, Cytokine, vol.12, issue.3, pp.246-252, 2000. ,
DOI : 10.1006/cyto.1999.0533
Altered cytokine profiles in patients with Chuvash polycythemia, American Journal of Hematology, vol.163, issue.2, pp.74-78, 2009. ,
DOI : 10.1002/ajh.21327
The role of hypoxia in inflammatory disease (Review), International Journal of Molecular Medicine, vol.35, issue.4, pp.859-869, 2015. ,
DOI : 10.3892/ijmm.2015.2079
Hypoxia-inducible factor-2í µí»¼ is an essential catabolic regulator of inflammatory rheumatoid arthritis, PLoS Biology, vol.12, issue.6, pp.1-16, 2014. ,
HIF-1?? Is Essential for Myeloid Cell-Mediated Inflammation, Cell, vol.112, issue.5, pp.645-657, 2003. ,
DOI : 10.1016/S0092-8674(03)00154-5
Evidence that the JAK2 G1849T (V617F) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis, Blood, vol.109, issue.1, pp.71-77, 2007. ,
DOI : 10.1182/blood-2006-03-007146
Kaposi's Sarcoma???Associated Herpesvirus-Like DNA Sequences in AIDS-Related Body-Cavity???Based Lymphomas, New England Journal of Medicine, vol.332, issue.18, pp.1186-1191, 1995. ,
DOI : 10.1056/NEJM199505043321802
Infection As a Cause of Human Cancers, 1999. ,
Epstein???Barr Virus Infection, New England Journal of Medicine, vol.343, issue.7, pp.481-492, 2000. ,
DOI : 10.1056/NEJM200008173430707
Gastric MALT lymphoma: from aetiology to treatment, The Lancet Oncology, vol.3, issue.2, pp.97-104, 2002. ,
DOI : 10.1016/S1470-2045(02)00651-4
The Lymphoid System in Hepatitis C Virus Infection: Autoimmunity, Mixed Cryoglobulinemia, and Overt B-Cell Malignancy, Seminars in Liver Disease, vol.20, issue.02, pp.143-157, 2000. ,
DOI : 10.1055/s-2000-9613
HCV and tumors correlated with immune system: a case-control study in an area of hyperendemicity, Leukemia Research, vol.25, issue.9, pp.775-781, 2001. ,
DOI : 10.1016/S0145-2126(01)00027-3
Pathogenesis, Journal of Cellular Physiology, vol.40, issue.8, pp.1702-1707, 2015. ,
DOI : 10.1002/jcp.24933
Signalling: STATs: transcriptional control and biological impact, Nature Reviews Molecular Cell Biology, vol.93, issue.9, pp.651-662, 2002. ,
DOI : 10.1038/nrm909
Regulation of Hypoxia???Inducible Factors During Inflammation, Methods in Enzymology, vol.435, pp.403-419, 2007. ,
DOI : 10.1016/S0076-6879(07)35021-0
Hypoxia regulates inflammatory gene expression in endothelial cells, Experimental Cell Research, vol.315, issue.5, pp.733-747, 2008. ,
DOI : 10.1016/j.yexcr.2008.11.020
Integration of Oxygen Signaling at the Consensus HRE, Science Signaling, vol.2005, issue.306, 2005. ,
DOI : 10.1126/stke.3062005re12
Transforming growth factor-?? signalling: Role and consequences of Smad linker region phosphorylation, Cellular Signalling, vol.25, issue.10, pp.2017-2024, 2013. ,
DOI : 10.1016/j.cellsig.2013.06.001
FGF2 translationally induced by hypoxia is involved in negative and positive feedback loops with HIF-1í µí»¼, PLoS ONE, vol.3, issue.8, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00317714
The JAK-STAT Pathway at Twenty, Immunity, vol.36, issue.4, pp.503-514, 2012. ,
DOI : 10.1016/j.immuni.2012.03.013
URL : http://doi.org/10.1016/j.immuni.2012.03.013
Erythropoietin in heart and vessels: focus on transcription and signalling pathways, Journal of Thrombosis and Thrombolysis, vol.72, issue.1, pp.183-187, 2008. ,
DOI : 10.1007/s11239-008-0212-3
Regulation of colony-stimulating factor-induced human myelopoiesis by transforming growth factor-?? isoforms, Cytokines, Cellular & Molecular Therapy, vol.7, issue.1, pp.31-36, 2002. ,
DOI : 10.1080/13684730216400
The regulation of TGF-??/SMAD signaling by protein deubiquitination, Protein & Cell, vol.400, issue.5, pp.503-517, 2014. ,
DOI : 10.1007/s13238-014-0058-8
Plasma cytokines in polycythemia vera: Phenotypic correlates, prognostic relevance, and comparison with myelofibrosis, American Journal of Hematology, vol.117, issue.11, pp.1003-1005, 2012. ,
DOI : 10.1002/ajh.23295
Cytokine profiles in polycythemia vera and essential thrombocythemia patients: Clinical implications, Experimental Hematology, vol.42, issue.5, pp.360-368, 2014. ,
DOI : 10.1016/j.exphem.2014.01.006
URL : https://hal.archives-ouvertes.fr/hal-00949162
Interleukin-8 and other agonists of Gi2 proteins: autocrine paracrine growth factors for human hematopoietic progenitors acting in synergy with colony stimulating factors, Leukemia and Lymphoma, vol.38, issue.12, pp.39-48, 2000. ,
ABNORMAL PRODUCTION OF INTERLEUKIN (IL)-11 AND IL-8 IN POLYCYTHAEMIA VERA, Cytokine, vol.20, issue.4, pp.178-183, 2002. ,
DOI : 10.1006/cyto.2002.1994
Anti-inflammatory cytokines hepatocyte growth factor and interleukin-11 are over-expressed in Polycythemia vera and contribute to the growth of clonal erythroblasts independently of JAK2V617F, Oncogene, vol.82, issue.8, pp.990-1001, 2011. ,
DOI : 10.1007/s00005-008-0022-5
Circulating Interleukin (IL)-8, IL-2R, IL-12, and IL-15 Levels Are Independently Prognostic in Primary Myelofibrosis: A Comprehensive Cytokine Profiling Study, Journal of Clinical Oncology, vol.29, issue.10, pp.1356-1363, 2011. ,
DOI : 10.1200/JCO.2010.32.9490
The HSC niche concept has turned 31, Annals of the New York Academy of Sciences, vol.113, issue.1, pp.12-18, 2010. ,
DOI : 10.1111/j.1749-6632.2009.05223.x
Primary myelofibrosis and the 'bad seeds in bad soil' concept, Fibrogenesis and Tissue Repair, vol.5, 2012. ,
Does primary myelofibrosis involve a defective stem cell niche? From concept to evidence, Blood, vol.112, issue.8, pp.3026-3035, 2008. ,
DOI : 10.1182/blood-2008-06-158386
Erythropoietin-independent erythroid colony formation by bone marrow progenitors exposed to interleukin-11 and interleukin-8, Experimental Hematology, vol.33, issue.11, pp.1299-1308, 2005. ,
DOI : 10.1016/j.exphem.2005.07.002
TNF?? facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms, Blood, vol.118, issue.24, pp.6392-6398, 2011. ,
DOI : 10.1182/blood-2011-04-348144
Diagnostic value of serum erythropoietin level in patients with absolute erythrocytosis, Haematologica, vol.89, issue.10, pp.1194-1279, 2004. ,
IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms, Journal of Clinical Investigation, vol.125, issue.7, pp.2579-2591, 2015. ,
DOI : 10.1172/JCI77347DS1
Autoimmunity and the risk of myeloproliferative neoplasms, Haematologica, vol.95, issue.7, pp.1216-1220, 2010. ,
DOI : 10.3324/haematol.2009.020412
Dual implication of fibrogenic cytokines in the pathogenesis of fibrosis and myeloproliferation in myeloid metaplasia with myelofibrosis, Annals of Hematology, vol.78, issue.10, pp.437-444, 1999. ,
DOI : 10.1007/s002770050595
Inflammation and thrombosis in essential thrombocythemia and polycythemia vera: different role of C-reactive protein and pentraxin 3, Haematologica, vol.96, issue.2, pp.315-318, 2011. ,
DOI : 10.3324/haematol.2010.031070
Elevated C-reactive protein is associated with shortened leukemia-free survival in patients with myelofibrosis, Leukemia, vol.37, issue.10, pp.2084-2086, 2013. ,
DOI : 10.1038/leu.2013.207
The JAK2V617F allele burden and STAT3- and STAT5 phosphorylation in myeloproliferative neoplasms: early prefibrotic myelofibrosis compared with essential thrombocythemia, polycythemia vera and myelofibrosis, APMIS, vol.35, issue.8, pp.498-504, 2011. ,
DOI : 10.1111/j.1600-0463.2011.02754.x
Effects of Clinically Relevant MPL Mutations in the Transmembrane Domain Revealed at the Atomic Level through Computational Modeling, PLoS ONE, vol.137, issue.8, 2011. ,
DOI : 10.1371/journal.pone.0023396.t001
Thrombopoietin from beginning to end, British Journal of Haematology, vol.84, issue.2, pp.259-268, 2014. ,
DOI : 10.1111/bjh.12772
TPO signal for stem cell genomic integrity, Blood, vol.123, issue.4, pp.459-460, 2014. ,
DOI : 10.1182/blood-2013-11-537084
LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations, Leukemia, vol.118, issue.10, pp.1713-1718, 2010. ,
DOI : 10.1158/0008-5472.CAN-09-3783
250K Single Nucleotide Polymorphism Array Karyotyping Identifies Acquired Uniparental Disomy and Homozygous Mutations, Including Novel Missense Substitutions of c-Cbl, in Myeloid Malignancies, Cancer Research, vol.68, issue.24, pp.10349-10357, 2008. ,
DOI : 10.1158/0008-5472.CAN-08-2754
Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms, Blood, vol.113, issue.24, pp.6182-6192, 2009. ,
DOI : 10.1182/blood-2008-12-194548
Lnk constrains myeloproliferative diseases in mice, Journal of Clinical Investigation, vol.120, issue.6, pp.2058-2069, 2010. ,
DOI : 10.1172/JCI42032DS1
in Myeloid Cancers, New England Journal of Medicine, vol.360, issue.22, pp.2289-2301, 2009. ,
DOI : 10.1056/NEJMoa0810069
Mutations of ASXL1 gene in myeloproliferative neoplasms, Leukemia, vol.23, issue.11, pp.2183-2186, 2009. ,
DOI : 10.1038/ng.349
Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome, New England Journal of Medicine, vol.361, issue.11, pp.1058-1066, 2009. ,
DOI : 10.1056/NEJMoa0903840
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201812
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders, Nature Genetics, vol.8, issue.8, pp.722-726, 2010. ,
DOI : 10.1016/j.molcel.2008.10.016
Leukemic IDH1 and IDH2 Mutations Result in??a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation, Cancer Cell, vol.18, issue.6, pp.553-567, 2010. ,
DOI : 10.1016/j.ccr.2010.11.015
URL : http://doi.org/10.1016/j.ccr.2010.11.015
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1, Science, vol.324, issue.5929, pp.930-935, 2009. ,
DOI : 10.1126/science.1170116
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification, Nature, vol.22, issue.7310, pp.1129-1133, 2010. ,
DOI : 10.1038/nature09303
Genetics of Myeloproliferative Neoplasms, The Cancer Journal, vol.20, issue.1, pp.61-65, 2014. ,
DOI : 10.1097/PPO.0000000000000013
Recurring mutations in myeloproliferative neoplasms alter epigenetic regulation of gene expression, American Journal of Cancer Research, vol.1, issue.6, pp.752-762, 2011. ,
JAK-STAT Pathway Activation in Malignant and Nonmalignant Cells Contributes to MPN Pathogenesis and Therapeutic Response, Cancer Discovery, vol.5, issue.3, pp.316-331, 2015. ,
DOI : 10.1158/2159-8290.CD-14-0736
Identification of oncostatin M as a JAK2 V617F-dependent amplifier of cytokine production and bone marrow remodeling in myeloproliferative neoplasms, The FASEB Journal, vol.26, issue.2, pp.894-906, 2012. ,
DOI : 10.1096/fj.11-193078
Soluble Calreticulin Induces Tumor Necrosis Factor-?? (TNF-??) and Interleukin (IL)-6 Production by Macrophages through Mitogen-Activated Protein Kinase (MAPK) and NF??B Signaling Pathways, International Journal of Molecular Sciences, vol.15, issue.2, pp.2916-2928, 2014. ,
DOI : 10.3390/ijms15022916
URL : http://doi.org/10.3390/ijms15022916
IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis, Leukemia, vol.114, issue.7, pp.1302-1309, 2010. ,
DOI : 10.1182/blood-2008-12-194548
Mutations and prognosis in primary myelofibrosis, Leukemia, vol.27, issue.9, pp.1861-1869, 2013. ,
DOI : 10.1200/JCO.2010.32.9490
SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS, Leukemia, 2014. ,
DOI : 10.1038/leu.2014.301
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501574
A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms, Nature Genetics, vol.57, issue.4, pp.450-454, 2009. ,
DOI : 10.1093/bioinformatics/bth457
JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms, Nature Genetics, vol.447, issue.4, pp.446-449, 2009. ,
DOI : 10.1182/blood-2005-09-3917
A germline JAK2 SNP is associated with predisposition to the development of JAK2V617F-positive myeloproliferative neoplasms, Nature Genetics, vol.447, issue.4, pp.455-459, 2009. ,
DOI : 10.1038/ng1847
locus contributes to familial clustering of myeloproliferative neoplasms, American Journal of Hematology, vol.112, issue.12, pp.1107-1110, 2014. ,
DOI : 10.1002/ajh.23842
Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms, Nature Communications, vol.26, p.6691, 2015. ,
DOI : 10.1038/ncomms7691
URL : http://doi.org/10.1038/ncomms7691
The prognostic impact of germline 46/1 haplotype of Janus kinase 2 in cytogenetically normal acute myeloid leukemia, Haematologica, vol.96, issue.11, pp.1613-1618, 2011. ,
DOI : 10.3324/haematol.2011.043885
The JAK2 46/1 haplotype: a marker of inappropriate myelomonocytic response to cytokine stimulation, leading to increased risk of inflammation, myeloid neoplasm, and impaired defense against infection?, Haematologica, vol.96, issue.11, pp.1575-1579, 2011. ,
DOI : 10.3324/haematol.2011.055392
A ???telomere-associated secretory phenotype??? cooperates with BCR-ABL to drive malignant proliferation of leukemic cells, Leukemia, vol.51, issue.10, pp.2028-2039, 2014. ,
DOI : 10.1038/leu.2014.95
MDS1/EVI1 enhances TGF-??1 signaling and strengthens its growth-inhibitory effect, but the leukemia-associated fusion protein AML1/MDS1/EVI1, product of the t(3;21), abrogates growth-inhibition in response to TGF-??1, Leukemia, vol.13, issue.3, pp.348-357, 1999. ,
DOI : 10.1038/sj.leu.2401360
, a target gene for amplification at 3q26, antagonizes transforming growth factor-??-mediated growth inhibition in hepatocellular carcinoma, Cancer Science, vol.74, issue.7, pp.929-937, 2015. ,
DOI : 10.1111/cas.12694
Th1/Th2 cytokines and their genotypes as predictors of hepatitis B virus related hepatocellular carcinoma, World Journal of Hepatology, vol.7, issue.11, pp.1572-1580, 2015. ,
DOI : 10.4254/wjh.v7.i11.1572
gene promoter polymorphisms contribute to periodontitis susceptibility: evidence from 46 studies, Journal of Clinical Periodontology, vol.42, issue.Suppl 1, pp.748-759, 2014. ,
DOI : 10.1111/jcpe.12279
Cytokine Gene Considerations in Giant Cell Arteritis: IL10 Promoter Polymorphisms and a Review of the Literature, Clinical Reviews in Allergy & Immunology, vol.6, issue.12 suppl, pp.56-64, 2012. ,
DOI : 10.1007/s12016-013-8405-8
???251 T/A polymorphism of the interleukin-8 gene and cancer risk: a HuGE review and meta-analysis based on 42 case???control studies, Molecular Biology Reports, vol.36, issue.6, pp.2831-2841, 2012. ,
DOI : 10.1007/s11033-011-1042-5
IL-10 and TNFí µí»¼ genotypes in SLE, Journal of Biomedicine and Biotechnology, vol.2010, 2010. ,
IL-8 ???251A/T polymorphism is associated with decreased cancer risk among population-based studies: Evidence from a meta-analysis, European Journal of Cancer, vol.46, issue.8, pp.1333-1343, 2010. ,
DOI : 10.1016/j.ejca.2010.03.011
Chapter 5 Proinflammatory cytokines in CRP baseline regulation, Advances in Clinical Chemistry, vol.48, pp.111-136, 2009. ,
DOI : 10.1016/S0065-2423(09)48005-3
MCP-1/CCL2: a new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy, AJP: Renal Physiology, vol.294, issue.4, pp.697-701, 2008. ,
DOI : 10.1152/ajprenal.00016.2008
Could single-nucleotide polymorphisms (SNPs) affecting the tumour necrosis factor promoter be considered as part of rheumatoid arthritis evolution?, Immunobiology, vol.211, issue.1-2, pp.75-84, 2006. ,
DOI : 10.1016/j.imbio.2005.09.005
Cytokine Promoter Polymorphisms in Severe Sepsis, Clinical Infectious Diseases, vol.41, issue.Supplement 7, pp.416-420, 2005. ,
DOI : 10.1086/431991
Tumor necrosis factor alpha genetic polymorphism as a risk factor in disease, Revista Medica de Chile, vol.130, issue.9, pp.1043-1050, 2002. ,
Genetic association of interleukin-6 polymorphism (-174 G/C) with chronic liver diseases and hepatocellular carcinoma, World Journal of Gastroenterology, vol.19, issue.16, pp.2449-2455, 2013. ,
DOI : 10.3748/wjg.v19.i16.2449
Decoding asthma: Translating genetic variation in IL33 and IL1RL1 into disease pathophysiology, Journal of Allergy and Clinical Immunology, vol.131, issue.3, pp.856-865, 2013. ,
DOI : 10.1016/j.jaci.2012.11.028
Genetics of Interleukin 1 Receptor-Like 1 in Immune and Inflammatory Diseases, Current Genomics, vol.11, issue.8, pp.591-606, 2010. ,
DOI : 10.2174/138920210793360907
Identification of 21 single nucleotide polymorphisms in human hepatocyte growth factor gene and association with blood pressure and carotid atherosclerosis in the Japanese population, Atherosclerosis, vol.173, issue.2, pp.301-307, 2004. ,
DOI : 10.1016/j.atherosclerosis.2003.12.020
Prognostic and predictive role of vascular??endothelial growth factor polymorphisms in breast cancer, Pharmacogenomics, vol.16, issue.1, pp.79-94, 2015. ,
DOI : 10.2217/pgs.14.148
Interleukin-6 polymorphisms and hematologic malignancy: a re-appraisal of evidence from genetic association studies, Biomarkers, vol.11, issue.7, pp.625-631, 2013. ,
DOI : 10.1080/02664763.2012.722611
Interleukin 6 ???174G>C polymorphism and cancer risk: Meta-analysis reveals a site dependent differential influence in Ancestral North Indians, Human Immunology, vol.75, issue.8, pp.901-908, 2014. ,
DOI : 10.1016/j.humimm.2014.06.018
The Hepatocyte Growth Factor (HGF)/Met Axis: A Neglected Target in the Treatment of Chronic Myeloproliferative Neoplasms?, Cancers, vol.6, issue.3, pp.1631-1669, 2014. ,
DOI : 10.3390/cancers6031631
URL : https://hal.archives-ouvertes.fr/inserm-01401601
Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?, Leukemia Research, vol.37, issue.2, pp.214-220, 2013. ,
DOI : 10.1016/j.leukres.2012.10.020
Chronic myeloproliferative neoplasms and subsequent cancer risk: a Danish population-based cohort study, Blood, vol.118, issue.25, pp.6515-6520, 2011. ,
DOI : 10.1182/blood-2011-04-348755
JAK Inhibition Impairs NK Cell Function in Myeloproliferative Neoplasms, Cancer Research, vol.75, issue.11, pp.2187-2199, 2015. ,
DOI : 10.1158/0008-5472.CAN-14-3198
Cryoglobulinemia, Blood Reviews, vol.21, issue.4, pp.183-200, 2007. ,
DOI : 10.1016/j.blre.2006.12.002
Hepatitis C Virus, Human Herpesvirus 8, and the Development of Plasma-Cell Leukemia, New England Journal of Medicine, vol.348, issue.2, pp.178-179, 2003. ,
DOI : 10.1056/NEJM200301093480219
Hepatitis C virus (HCV) infection, monoclonal immunoglobulin specific for HCV core protein, and plasma-cell malignancy, Blood, vol.112, issue.10, pp.4357-4358, 2008. ,
DOI : 10.1182/blood-2008-07-167569
Chronic viral infection, virus-specific monoclonal immunoglobulin, and development of plasma cell malignancy, Blood, vol.118, issue.21, pp.1240-1241, 2011. ,
Multiplexed infectious protein microarray immunoassay suitable for the study of the specificity of monoclonal immunoglobulins, Analytical Biochemistry, vol.433, issue.2, pp.202-209, 2013. ,
DOI : 10.1016/j.ab.2012.10.012
URL : https://hal.archives-ouvertes.fr/inserm-01401584
Regression of a case of Multiple Myeloma with antiviral treatment in a patient with chronic HCV infection, Leukemia Research Reports, vol.2, issue.1, pp.39-40, 2013. ,
DOI : 10.1016/j.lrr.2013.01.002
Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2-V617F mouse model of MPN, Blood, vol.125, issue.13, pp.2131-2140, 2015. ,
DOI : 10.1182/blood-2014-08-594572
The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis, Blood, vol.105, issue.9, pp.3512-3520, 2005. ,
DOI : 10.1182/blood-2004-09-3751
Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis, Blood, vol.109, issue.6, pp.2380-2388, 2007. ,
DOI : 10.1182/blood-2006-08-040352
BCR-ABL induces opposite phenotypes in murine ES cells according to STAT3 activation levels, Cellular Signalling, vol.21, issue.1, pp.52-60, 2009. ,
DOI : 10.1016/j.cellsig.2008.09.006
Transcription Factor NF-??B Inhibitors as Single Therapeutic Agents or in Combination with Classical Chemotherapeutic Agents for the Treatment of Hematologic Malignancies, Current Molecular Pharmacology, vol.3, issue.3, pp.98-122, 2010. ,
DOI : 10.2174/1874467211003030098
Pristimerin induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation by blocking NF-í µí¼ B signaling and depleting Bcr-Abl Strategic targeting of the PI3K-NFí µí¼ B axis in cisplatin-resistant NSCLC, Molecular Cancer Cancer Biology and Therapy, vol.9, issue.15 10, pp.1367-1377, 2010. ,
HIF-1 as a Target for Cancer Chemotherapy, Chemosensitization and Chemoprevention, Current Molecular Pharmacology, vol.4, issue.1, pp.62-77, 2011. ,
DOI : 10.2174/1874467211104010062
Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors, European Journal of Medicinal Chemistry, vol.49, pp.24-40, 2012. ,
DOI : 10.1016/j.ejmech.2012.01.033
Design, synthesis and biological evaluation of novel HIF1í µí»¼ Inhibitors, Anticancer Research, vol.35, issue.7, pp.3849-3859, 2015. ,
Phase I/II study of single-agent bortezomib for the treatment of patients with myelofibrosis. Clinical and biological effects of proteasome inhibition, American Journal of Hematology, vol.21, issue.8, pp.616-619, 2010. ,
DOI : 10.1002/ajh.21754
Inhibition of interleukin-11 by interferon-í µí»¼ in human bone marrow stromal cells, Experimental Hematology, vol.24, issue.8, pp.863-867, 1996. ,
Interferon-?? activates multiple STAT signals and down-regulates c-Met in primary human hepatocytes, Gastroenterology, vol.122, issue.4, pp.1020-1034, 2002. ,
DOI : 10.1053/gast.2002.32388
Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial, The Lancet Oncology, vol.15, issue.13, pp.1451-1459, 2014. ,
DOI : 10.1016/S1470-2045(14)71017-4
MET inhibitors for treatment of advanced hepatocellular carcinoma: A review, World Journal of Gastroenterology, vol.21, issue.18, pp.5445-5453, 2015. ,
DOI : 10.3748/wjg.v21.i18.5445
Tumour necrosis factor inhibitors versus combination intensive therapy with conventional disease modifying anti-rheumatic drugs in established rheumatoid arthritis: TACIT non-inferiority randomised controlled trial, BMJ, vol.350, issue.mar13 19, 2015. ,
DOI : 10.1136/bmj.h1046
Pathogenesis beyond the cancer clone(s) in multiple myeloma, Blood, vol.125, issue.20, pp.3049-3058, 2015. ,
DOI : 10.1182/blood-2014-11-568881
The human microbiome in hematopoiesis and hematologic disorders, Blood, vol.126, issue.3, pp.311-318, 2015. ,
DOI : 10.1182/blood-2015-04-574392
Viral immunology Comprehensive serological profiling of human populations using a synthetic human virome, Science, vol.348, issue.6239, 2015. ,
Chronic Exposure to a TLR Ligand Injures Hematopoietic Stem Cells, The Journal of Immunology, vol.186, issue.9, pp.5367-5375, 2011. ,
DOI : 10.4049/jimmunol.1003438
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086167