Low-Dose Pesticide Mixture Induces Senescence In Normal Mesenchymal Stem Cells (MSC) And Promotes Tumorigenic Phenotype In Premalignant MSC

Abstract : Humans are chronically exposed to multiple environmental pollutants such as pesticides with no significant evidence about the safety of such poly-exposures. We exposed mesenchymal stem cells (MSC) to very low doses of mixture of seven pesticides frequently detected in food samples for 21 days in vitro. We observed a permanent phenotype modification with a specific induction of an oxidative stress-related senescence. Pesticide mixture also induced a shift in MSC differentiation towards adipogenesis but did not initiate a tumorigenic transformation. In modified MSC in which a premalignant phenotype wasinduced, the exposure to pesticide mixture promoted tumorigenic phenotype both in vitro andin vivo after cell implantation, in all nude mice. Our results suggest that a commoncombination of pesticides can induce a premature ageing of adult MSC, and as such couldaccelerate age-related diseases. Exposure to pesticide mixture may also promote thetumorigenic transformation in a predisposed stromal environment.
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STEM CELLS, AlphaMed Press, 2016
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Soumis le : jeudi 17 novembre 2016 - 14:53:10
Dernière modification le : jeudi 5 avril 2018 - 10:37:01

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Mazène Hochane, Valérie Trichet, Claire Pecqueur, Pierre Avril, Lisa Oliver, et al.. Low-Dose Pesticide Mixture Induces Senescence In Normal Mesenchymal Stem Cells (MSC) And Promotes Tumorigenic Phenotype In Premalignant MSC. STEM CELLS, AlphaMed Press, 2016. 〈inserm-01398601〉

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