Spitting out the demons: Extracellular vesicles in glioblastoma

Gwennan André-Grégoire 1, 2 Julie Gavard 1, 2, *
* Auteur correspondant
2 Equipe 15 - SOAP - Signaling in Oncogenesis, Angiogenesis and Permeability
CHU Angers, Hôtel-Dieu de Nantes, Hôpital Laennec, CNRS - Centre National de la Recherche Scientifique : UMR6299, CRCNA - Centre de Recherche en Cancérologie/Nantes - Angers
Abstract : Discovered decades ago, extracellular vesicles (EVs) emerge as dedicated organelles, able to deliver protected, specific cellular cues throughout the organism. While virtually every cell can release EVs, cancer cells co-opted this feature and efficiently unleashed them both in the tumor microenvironment and towards healthy tissues. This might contribute to tumor aggressiveness and spreading. Cancer-derived EVs that contain DNA, mRNA, miRNA, and packed and transmembrane proteins can operate locally or at distance. This review will focus on the high-grade brain tumor (i.e. glioblastoma)-derived EVs, discussing recent reports on i) their phenotype and content, ii) their putative functions, and iii) their clinical potential for improving diagnosis and therapeutics.
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Article dans une revue
Cell Adhesion and Migration, Taylor & Francis, 2016, [Epub ahead of print]. 〈10.1080/19336918.2016.1247145〉
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Soumis le : lundi 17 octobre 2016 - 09:18:34
Dernière modification le : jeudi 15 mars 2018 - 14:10:54

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Gwennan André-Grégoire, Julie Gavard. Spitting out the demons: Extracellular vesicles in glioblastoma. Cell Adhesion and Migration, Taylor & Francis, 2016, [Epub ahead of print]. 〈10.1080/19336918.2016.1247145〉. 〈inserm-01382405〉

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