G+C content differs in conserved and variable amino acid residues of flaviviruses and other evolutionary groups.

Abstract : Flaviviruses are small RNA viruses that exhibit genetic and ecological diversity and a wide range of G+C content (GC%). We discovered that, amongst flaviviruses, the GC% of nucleotides encoding conserved amino acid (AA) residues was consistently higher than that of nucleotides encoding variable AAs. This intriguing phenomenon was also identified for a wide range of other viruses, and some non-viral evolutionary groups. Here, we analyse the possible mechanisms underlying this imbalanced nucleotide content (in particular the role of the specific G content and the AA composition in flaviviral genomes) and discuss its evolutionary implications. Our findings suggest that one of the most simple characteristics of the genetic code (i.e., the G or G+C content of codons) is linked with the evolutionary behavior of the corresponding encoded AAs.
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Infection, Genetics and Evolution, Elsevier, 2016, 45, pp.332-340. 〈10.1016/j.meegid.2016.09.017.〉
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Raphaëlle Klitting, Ernest Gould, Xavier De Lamballerie. G+C content differs in conserved and variable amino acid residues of flaviviruses and other evolutionary groups.. Infection, Genetics and Evolution, Elsevier, 2016, 45, pp.332-340. 〈10.1016/j.meegid.2016.09.017.〉. 〈inserm-01375999〉

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