Weight and weight changes throughout life and postmenopausal breast cancer risk: a case-control study in France - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue BMC Cancer Année : 2015

Weight and weight changes throughout life and postmenopausal breast cancer risk: a case-control study in France

Résumé

AbstractBackgroundOverweight and weight gain throughout adult life have been associated with increased risk of breast cancer after the menopause. However the role of body weight at a young age and of the timing of weight gain over the lifetime in postmenopausal breast cancer is not well documented.MethodsWe conducted a population-based case-control study on breast cancer in France that included 739 cases and 815 population controls in postmenopausal women. Height, weight at age 20, 40 and 50 as well as weight one year before diagnosis were obtained during in-person interviews.ResultsNo association between body mass index at the age of 20 years and breast cancer after the menopause was detected. However, we found that postmenopausal breast cancer was associated with weight gain between ages 40 and 50 years (OR per 5 kg/m2 increase in BMI: 1.45 [95%ci 1.06−1.98]). The increased risk of breast cancer associated with weight gain was more consistent in leaner women at age 20, in older postmenopausal women (>65 years), and in women who did not use menopausal hormone therapy.ConclusionsThese findings point to the importance of controlling for weight gain in middle aged-women. The role of low body weight in young adulthood in breast cancer risk after the menopause should be further scrutinized.
Fichier principal
Vignette du fichier
12885_2016_Article_2793.pdf (390.08 Ko) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

inserm-01373657 , version 1 (29-09-2016)

Identifiants

Citer

Emilie Cordina-Duverger, Thérèse Truong, Antoinette Anger, Marie Sanchez, Patrick Arveux, et al.. Weight and weight changes throughout life and postmenopausal breast cancer risk: a case-control study in France. BMC Cancer, 2015, 16 (1), pp.761. ⟨10.1186/s12885-016-2793-0⟩. ⟨inserm-01373657⟩
72 Consultations
106 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More