K. Fearon, F. Strasser, S. Anker, I. Bosaeus, E. Bruera et al., Definition and classification of cancer cachexia: an international consensus, The Lancet Oncology, vol.12, issue.5, pp.489-95, 2011.
DOI : 10.1016/S1470-2045(10)70218-7

A. Laviano, M. Meguid, A. Inui, M. Muscaritoli, and F. Rossi-fanelli, Therapy Insight: cancer anorexia???cachexia syndrome???when all you can eat is yourself, Nature Clinical Practice Oncology, vol.59, issue.3, pp.158-6510, 1038.
DOI : 10.1002/cncr.20160

K. Fearon, J. Arends, and V. Baracos, Understanding the mechanisms and treatment options in cancer cachexia, Nature Reviews Clinical Oncology, vol.34, issue.2, pp.90-99, 2013.
DOI : 10.1038/nrclinonc.2012.209

H. Suzuki, A. Asakawa, H. Amitani, N. Nakamura, and A. Inui, Cancer cachexia???pathophysiology and management, Journal of Gastroenterology, vol.104, issue.7, pp.574-94, 2013.
DOI : 10.1007/s00535-013-0787-0

D. Osoba, B. Zee, D. Warr, L. Kaizer, J. Latreille et al., Quality of Life Studies in Chemotherapy-Induced Emesis, Oncology, vol.53, issue.1, pp.92-97, 1996.
DOI : 10.1159/000227647

S. Sonis, Mucositis as a biological process: a new hypothesis for the development of chemotherapy-induced stomatotoxicity, Oral Oncology, vol.34, issue.1, pp.39-4310, 1998.
DOI : 10.1016/S1368-8375(97)00053-5

N. Blijlevens, Implications of treatment-induced mucosal barrier injury, Curr Opin Oncol, vol.17, issue.6, pp.605-615, 2005.

M. Hofman, G. Morrow, J. Roscoe, J. Hickok, K. Mustian et al., Cancer patients' expectations of experiencing treatment-related side effects, Cancer, vol.65, issue.4, pp.851-858, 2004.
DOI : 10.1002/cncr.20423

P. Gordon, S. Legrand, and D. Walsh, Nausea and vomiting in advanced cancer, European Journal of Pharmacology, vol.722, pp.187-91, 2014.
DOI : 10.1016/j.ejphar.2013.10.010

L. Bricon, T. Gugins, S. Cynober, L. Baracos, and V. , Negative impact of cancer chemotherapy on protein metabolism in healthy and tumor-bearing rats, Metabolism, vol.44, issue.10, pp.1340-1348, 1995.
DOI : 10.1016/0026-0495(95)90040-3

M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo et al., Ghrelin is a growth-hormone-releasing acylated peptide from stomach, Nature, vol.402, issue.6762, pp.656-601045230, 1038.
DOI : 10.1038/45230

M. Nakazato, N. Murakami, Y. Date, M. Kojima, H. Matsuo et al., A role for ghrelin in the central regulation of feeding, Nature, vol.409, issue.6817, pp.194-202, 2001.
DOI : 10.1038/35051587

M. Satou, Y. Nishi, J. Yoh, Y. Hattori, and H. Sugimoto, Identification and Characterization of Acyl-Protein Thioesterase 1/Lysophospholipase I As a Ghrelin Deacylation/Lysophospholipid Hydrolyzing Enzyme in Fetal Bovine Serum and Conditioned Medium, Endocrinology, vol.151, issue.10, pp.4765-752010, 2010.
DOI : 10.1210/en.2010-0412

H. Hosoda, M. Kojima, H. Matsuo, and K. Kangawa, Ghrelin and Des-acyl Ghrelin: Two Major Forms of Rat Ghrelin Peptide in Gastrointestinal Tissue, Biochemical and Biophysical Research Communications, vol.279, issue.3, pp.909-922, 2000.
DOI : 10.1006/bbrc.2000.4039

T. Müller and M. Tschöp, Ghrelin - A Key Pleiotropic Hormone-Regulating Systemic Energy Metabolism, Endocr Dev, vol.25, pp.91-100, 2013.
DOI : 10.1159/000346590

J. Chuang and J. Zigman, Ghrelin's Roles in Stress, Mood, and Anxiety Regulation, International Journal of Peptides, vol.109, issue.5, p.460549, 2010.
DOI : 10.1152/ajpendo.00196.2004

M. Lutter, I. Sakata, S. Osborne-lawrence, S. Rovinsky, J. Anderson et al., The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress, Nature Neuroscience, vol.9, issue.7, pp.752-755, 2008.
DOI : 10.1210/en.2005-1182

S. Spencer, L. Xu, M. Clarke, M. Lemus, A. Reichenbach et al., Ghrelin Regulates the Hypothalamic-Pituitary-Adrenal Axis and Restricts Anxiety After Acute Stress, Biological Psychiatry, vol.72, issue.6, pp.457-65, 2012.
DOI : 10.1016/j.biopsych.2012.03.010

N. Fujitsuka, A. Asakawa, Y. Uezono, K. Minami, T. Yamaguchi et al., Potentiation of ghrelin signaling attenuates cancer anorexia???cachexia and prolongs survival, Translational Psychiatry, vol.264, issue.7, 2011.
DOI : 10.1038/tp.2011.25

C. Pietra, Y. Takeda, N. Tazawa-ogata, M. Minami, X. Yuanfeng et al., Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexia syndrome: preclinical profile, Journal of Cachexia, Sarcopenia and Muscle, vol.97, issue.4, pp.329-366, 2014.
DOI : 10.1007/s13539-014-0159-5

H. Takeda, C. Sadakane, T. Hattori, T. Katsurada, T. Ohkawara et al., Rikkunshito, an Herbal Medicine, Suppresses Cisplatin-Induced Anorexia in Rats Via 5-HT2 Receptor Antagonism, Gastroenterology, vol.134, issue.7, pp.2004-2017, 2008.
DOI : 10.1053/j.gastro.2008.02.078

Y. Hiura, S. Takiguchi, K. Yamamoto, Y. Kurokawa, M. Yamasaki et al., Fall in plasma ghrelin concentrations after cisplatin-based chemotherapy in esophageal cancer patients, International Journal of Clinical Oncology, vol.22, issue.4, pp.316-339, 2012.
DOI : 10.1007/s10147-011-0289-0

Y. Hiura, S. Takiguchi, K. Yamamoto, T. Takahashi, Y. Kurokawa et al., Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients, Cancer, vol.7, issue.19, pp.4785-94, 2012.
DOI : 10.1002/cncr.27430

S. Perboni, C. Bowers, S. Kojima, A. Asakawa, and A. Inui, Growth hormone releasing peptide 2 reverses anorexia associated with chemotherapy with 5-fluoruracil in colon cancer cell-bearing mice, World Journal of Gastroenterology, vol.14, issue.41, pp.6303-6308, 2008.
DOI : 10.3748/wjg.14.6303

G. Longo-sorbello and J. Bertino, Current understanding of methotrexate pharmacology and efficacy in acute leukemias. Use of newer antifolates in clinical trials, Haematologica, vol.86, issue.2, pp.121-128, 2001.

J. Leblond, L. Pessot, F. Hubert-buron, A. Duclos, C. Vuichoud et al., Chemotherapy-Induced Mucositis Is Associated with Changes in Proteolytic Pathways, Experimental Biology and Medicine, vol.233, issue.2, pp.219-247, 2008.
DOI : 10.3181/0702-RM-49

N. Boukhettala, J. Leblond, S. Claeyssens, M. Faure, L. Pessot et al., Methotrexate induces intestinal mucositis and alters gut protein metabolism independently of reduced food intake, AJP: Endocrinology and Metabolism, vol.296, issue.1, pp.182-90, 2008.
DOI : 10.1152/ajpendo.90459.2008

I. Alamir, N. Boukhettala, M. Aziz, D. Breuillé, P. Déchelotte et al., Beneficial effects of cathepsin inhibition to prevent chemotherapy-induced intestinal mucositis, Clinical & Experimental Immunology, vol.82, issue.2, pp.298-305, 2010.
DOI : 10.1111/j.1365-2249.2010.04220.x

S. Beutheu, W. Ouelaa, C. Guérin, L. Belmonte, M. Aziz et al., Glutamine supplementation, but not combined glutamine and arginine supplementation, improves gut barrier function during chemotherapy-induced intestinal mucositis in rats, Clinical Nutrition, vol.33, issue.4, pp.694-701, 2014.
DOI : 10.1016/j.clnu.2013.09.003

H. Sinno, M. Coquerel, Q. Boukhettala, N. Coëffier, M. Gallas et al., Chemotherapy-induced anorexia is accompanied by activation of brain pathways signaling dehydration, Physiology & Behavior, vol.101, issue.5, pp.639-687, 2010.
DOI : 10.1016/j.physbeh.2010.09.016

K. Takagi, R. Legrand, A. Asakawa, H. Amitani, M. François et al., Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans, Nature Communications, vol.789, 2013.
DOI : 10.1038/35038090

Q. Coquerel, H. Sinno, M. Boukhettala, N. Coëffier, M. Terashi et al., Intestinal inflammation influences ??-MSH reactive autoantibodies: Relevance to food intake and body weight, Psychoneuroendocrinology, vol.37, issue.1, pp.94-106, 2012.
DOI : 10.1016/j.psyneuen.2011.05.008

K. Bailey and J. Crawley, Anxiety-related behaviors in mice Methods of Behavior Analysis in Neuroscience, 2009.

S. Fetissov, Neuropeptide Autoantibodies Assay, Methods Mol Biol, vol.789, pp.295-302, 2011.
DOI : 10.1007/978-1-61779-310-3_19

R. Legrand, K. Takagi, and S. Fetissov, Immunoglobulin G preparation from plasma samples and analysis of its affinity kinetic binding to peptide hormones, Protoc Exch, 2014.

T. Shiiya, M. Nakazato, M. Mizuta, Y. Date, M. Mondal et al., Plasma Ghrelin Levels in Lean and Obese Humans and the Effect of Glucose on Ghrelin Secretion, The Journal of Clinical Endocrinology & Metabolism, vol.87, issue.1, pp.240-244, 2002.
DOI : 10.1210/jcem.87.1.8129

V. Coiro, G. Saccani-jotti, P. Rubino, G. Manfredi, P. Vacca et al., Oxytocin inhibits the stimulatory effect of ghrelin on circulating neuropeptide Y levels in humans, Journal of Neural Transmission, vol.25, issue.9, pp.1265-1272, 2008.
DOI : 10.1007/s00702-008-0057-0

D. Atasoy, J. Betley, H. Su, S. Sternson, J. Nedvídková et al., Deconstruction of a neural circuit for hunger doi:10.1038/nature11270 40 Loss of meal-induced decrease in plasma ghrelin levels in patients with anorexia nervosa, Nature J Clin Endocrinol Metab, vol.488, issue.884, pp.172-71678, 2003.

M. Misra, K. Miller, K. Kuo, K. Griffin, V. Stewart et al., Secretory dynamics of ghrelin in adolescent girls with anorexia nervosa and healthy adolescents, AJP: Endocrinology and Metabolism, vol.289, issue.2, pp.347-56, 2004.
DOI : 10.1152/ajpendo.00615.2004

V. Tolle, M. Kadem, M. Bluet-pajot, D. Frere, C. Foulon et al., Balance in Ghrelin and Leptin Plasma Levels in Anorexia Nervosa Patients and Constitutionally Thin Women, The Journal of Clinical Endocrinology & Metabolism, vol.88, issue.1, pp.109-162002, 2003.
DOI : 10.1210/jc.2002-020645

N. Germain, B. Galusca, D. Grouselle, D. Frere, V. Tolle et al., Ghrelin/obestatin ratio in two populations with low bodyweight: Constitutional thinness and anorexia nervosa, Psychoneuroendocrinology, vol.34, issue.3, pp.413-422, 2009.
DOI : 10.1016/j.psyneuen.2008.10.001

J. Goldstein, T. Zhao, R. Li, D. Sherbet, G. Liang et al., Surviving Starvation: Essential Role of the Ghrelin-Growth Hormone Axis, Cold Spring Harbor Symposia on Quantitative Biology, vol.76, issue.0, pp.121-128, 2011.
DOI : 10.1101/sqb.2011.76.010447

L. Verhagen, E. Egecioglu, M. Luijendijk, J. Hillebrand, R. Adan et al., Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity, European Neuropsychopharmacology, vol.21, issue.5, pp.384-92, 2011.
DOI : 10.1016/j.euroneuro.2010.06.005

M. Méquinion, E. Caron, S. Zgheib, A. Stievenard, P. Zizzari et al., Physical activity: benefit or weakness in metabolic adaptations in a mouse model of chronic food restriction?, American Journal of Physiology - Endocrinology And Metabolism, vol.308, issue.3, pp.241-55, 2015.
DOI : 10.1152/ajpendo.00340.2014

R. Legrand, N. Lucas, J. Breton, S. Azhar, J. Do-rego et al., Ghrelin treatment prevents development of activity based anorexia in mice, European Neuropsychopharmacology, vol.26, issue.6, pp.948-58, 2016.
DOI : 10.1016/j.euroneuro.2016.03.010

M. François, S. Barde, N. Achamrah, J. Breton, J. Do-rego et al., The number of preproghrelin mRNA expressing cells is increased in mice with activity-based anorexia, Neuropeptides, vol.51, pp.17-23, 2015.
DOI : 10.1016/j.npep.2015.04.003

J. Yang, M. Brown, G. Liang, N. Grishin, and J. Goldstein, Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone, Cell, vol.132, issue.3, pp.387-96, 2008.
DOI : 10.1016/j.cell.2008.01.017

Y. Shanado, M. Kometani, H. Uchiyama, S. Koizumi, and N. Teno, Lysophospholipase I identified as a ghrelin deacylation enzyme in rat stomach, Biochemical and Biophysical Research Communications, vol.325, issue.4, pp.1487-94, 2004.
DOI : 10.1016/j.bbrc.2004.10.193

M. François, S. Barde, R. Legrand, N. Lucas, S. Azhar et al., High-fat diet increases ghrelin-expressing cells in stomach, contributing to obesity, Nutrition, vol.32, issue.6, pp.709-724, 2016.
DOI : 10.1016/j.nut.2015.12.034

M. Terashi, A. Asakawa, T. Harada, M. Ushikai, Q. Coquerel et al., Ghrelin reactive autoantibodies in restrictive anorexia nervosa, Nutrition, vol.27, issue.4, pp.407-420, 2011.
DOI : 10.1016/j.nut.2011.01.002

R. Dantzer, M. Meagher, and C. Cleeland, Translational approaches to treatment-induced symptoms in cancer patients, Nature Reviews Clinical Oncology, vol.16, issue.7, pp.414-440, 2012.
DOI : 10.1038/nrclinonc.2012.88

M. Pandey, G. Sarita, N. Devi, B. Thomas, B. Hussain et al., Distress, anxiety, and depression in cancer patients undergoing chemotherapy, World Journal of Surgical Oncology, vol.4, issue.1, pp.68-78, 2006.
DOI : 10.1186/1477-7819-4-68

D. Mastro, L. Costantini, M. Morasso, G. Bonci, F. Bergaglio et al., Impact of two different dose-intensity chemotherapy regimens on psychological distress in early breast cancer patients, European Journal of Cancer, vol.38, issue.3, pp.359-66, 2002.
DOI : 10.1016/S0959-8049(01)00380-X

E. Haroon, C. Raison, and A. Miller, Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior, Neuropsychopharmacology, vol.31, issue.1, pp.137-62, 2011.
DOI : 10.1038/nm0602-625

R. Luna and J. Foster, Gut brain axis: diet microbiota interactions and implications for modulation of anxiety and depression, Current Opinion in Biotechnology, vol.32, pp.35-41, 2015.
DOI : 10.1016/j.copbio.2014.10.007

S. Fetissov and P. Déchelotte, The new link between gut???brain axis and neuropsychiatric disorders, Current Opinion in Clinical Nutrition and Metabolic Care, vol.14, issue.5, pp.477-82, 2011.
DOI : 10.1097/MCO.0b013e32834936e7

M. François, J. Schaefer, C. Bole-feysot, P. Déchelotte, F. Verhulst et al., Ghrelin-reactive immunoglobulins and anxiety