Vasoactive intestinal peptide is a local mediator in a gut-brain neural axis activating intestinal gluconeogenesis

Abstract : Intestinal gluconeogenesis (IGN) promotes metabolic benefits through activation of a gut-brain neural axis. However, the local mediator activating gluconeogenic genes in the enterocytes remains unknown. We show that (1) VIP signaling through VPAC1 receptor activates the intestinal glucose-6-phosphatase gene in vivo, (2) the activation of IGN by propionate is counteracted by VPAC1 antagonism, and (3) VIP-positive intrinsic neurons in the submucosal plexus are increased under the action of propionate. These data support the role of VIP as a local neuromodulator released by intrinsic enteric neurons and responsible for the induction through a VPAC1 receptor-dependent mechanism in enterocytes.
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Neurogastroenterology and Motility, Wiley, 2015, 27 (3), pp.443-448. 〈10.1016/j.molmet.2014.12.009〉
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Filipe De Vadder, Flora Plessier, Amandine Gautier-Stein, Gilles Mithieux. Vasoactive intestinal peptide is a local mediator in a gut-brain neural axis activating intestinal gluconeogenesis. Neurogastroenterology and Motility, Wiley, 2015, 27 (3), pp.443-448. 〈10.1016/j.molmet.2014.12.009〉. 〈inserm-01350922〉

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