Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis.

Abstract : Beneficial effects of dietary fiber on glucose and energy homeostasis have long been described, focusing mostly on the production of short-chain fatty acids by the gut commensal bacteria. However, bacterial fermentation of dietary fiber also produces large amounts of succinate and, to date, no study has focused on the role of succinate on host metabolism. Here, we fed mice a fiber-rich diet and found that succinate was the most abundant carboxylic acid in the cecum. Dietary succinate was identified as a substrate for intestinal gluconeogenesis (IGN), a process that improves glucose homeostasis. Accordingly, dietary succinate improved glucose and insulin tolerance in wild-type mice, but those effects were absent in mice deficient in IGN. Conventional mice colonized with the succinate producer Prevotella copri exhibited metabolic benefits, which could be related to succinate-activated IGN. Thus, microbiota-produced succinate is a previously unsuspected bacterial metabolite improving glycemic control through activation of IGN.
Type de document :
Article dans une revue
Cell, Elsevier, 2016, 156, pp.1-13. 〈10.1016/j.cell.2013.12.016〉
Liste complète des métadonnées

Littérature citée [29 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-01350754
Contributeur : Marie-Ange Di Carlo <>
Soumis le : lundi 1 août 2016 - 15:51:47
Dernière modification le : mardi 27 mars 2018 - 14:02:02
Document(s) archivé(s) le : mercredi 2 novembre 2016 - 11:42:58

Fichier

Cell 2014.Hal.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Filipe De Vadder, Petia Kovatcheva-Datchary, Carine Zitoun, Adeline Duchampt, Fredrik Bäckhed, et al.. Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis.. Cell, Elsevier, 2016, 156, pp.1-13. 〈10.1016/j.cell.2013.12.016〉. 〈inserm-01350754〉

Partager

Métriques

Consultations de la notice

187

Téléchargements de fichiers

197