Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Cell Année : 2016

Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis.

Résumé

Beneficial effects of dietary fiber on glucose and energy homeostasis have long been described, focusing mostly on the production of short-chain fatty acids by the gut commensal bacteria. However, bacterial fermentation of dietary fiber also produces large amounts of succinate and, to date, no study has focused on the role of succinate on host metabolism. Here, we fed mice a fiber-rich diet and found that succinate was the most abundant carboxylic acid in the cecum. Dietary succinate was identified as a substrate for intestinal gluconeogenesis (IGN), a process that improves glucose homeostasis. Accordingly, dietary succinate improved glucose and insulin tolerance in wild-type mice, but those effects were absent in mice deficient in IGN. Conventional mice colonized with the succinate producer Prevotella copri exhibited metabolic benefits, which could be related to succinate-activated IGN. Thus, microbiota-produced succinate is a previously unsuspected bacterial metabolite improving glycemic control through activation of IGN.
Fichier principal
Vignette du fichier
Cell 2014.Hal.pdf (1.94 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

inserm-01350754 , version 1 (01-08-2016)

Identifiants

Citer

Filipe de Vadder, Petia Kovatcheva-Datchary, Carine Zitoun, Adeline Duchampt, Fredrik Bäckhed, et al.. Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis.. Cell, 2016, 156, pp.1-13. ⟨10.1016/j.cell.2013.12.016⟩. ⟨inserm-01350754⟩
325 Consultations
443 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More