A. Abeliovich, Y. Schmitz, I. Fariñas, D. Choi-lundberg, W. H. Ho et al., Mice Lacking ??-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System, Neuron, vol.25, issue.1, pp.239-252, 2000.
DOI : 10.1016/S0896-6273(00)80886-7

L. Alvarez-erviti, M. C. Rodriguez-oroz, J. M. Cooper, C. Caballero, I. Ferrer et al., Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains, Archives of Neurology, vol.67, issue.12, pp.1464-1472, 2010.
DOI : 10.1001/archneurol.2010.198

D. Alvarez-fischer, C. Noelker, F. Vulinovi´c, A. Grünewald, C. Chevarin et al., Bee Venom and Its Component Apamin as Neuroprotective Agents in a Parkinson Disease Mouse Model, PLoS ONE, vol.20, issue.2, 2013.
DOI : 10.1371/journal.pone.0061700.s005

I. Ahmed, Y. Liang, S. Schools, V. L. Dawson, T. M. Dawson et al., Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired Autophagy, Journal of Neuroscience, vol.32, issue.46, pp.16503-16509, 2012.
DOI : 10.1523/JNEUROSCI.0209-12.2012

P. Anglade, S. Vyas, F. Javoy-agid, M. T. Herrero, P. P. Michel et al., Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease, Histol. Histopathol, vol.12, pp.25-31, 1997.

M. Assous, L. Had-aissouni, P. Gubellini, C. Melon, I. Nafia et al., Progressive Parkinsonism by acute dysfunction of excitatory amino acid transporters in the rat substantia nigra, Neurobiology of Disease, vol.65, pp.69-81, 2014.
DOI : 10.1016/j.nbd.2014.01.011

URL : https://hal.archives-ouvertes.fr/hal-01112500

C. Balducci, L. Pierguidi, E. Persichetti, L. Parnetti, M. Sbaragli et al., Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease, Movement Disorders, vol.349, issue.10, pp.1481-1484, 2007.
DOI : 10.1002/mds.21399

G. Bertolin, R. Ferrando-miguel, M. Jacoupy, S. Traver, K. Grenier et al., The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance, Autophagy, vol.269, issue.11, pp.1801-1817, 2013.
DOI : 10.1093/hmg/ddl131

G. Filomeni, D. De-zio, C. , and F. , Oxidative stress and autophagy: the clash between damage and metabolic needs, Cell Death and Differentiation, vol.942, issue.3, pp.377-88, 2015.
DOI : 10.1038/nrm3735

A. Fouillet, C. Levet, A. Virgone, M. Robin, P. Dourlen et al., ER stress inhibits neuronal death by promoting autophagy, Autophagy, vol.267, issue.6, pp.915-926, 2012.
DOI : 10.1111/j.1471-4159.2008.05217.x

URL : https://hal.archives-ouvertes.fr/ensl-00807628

L. G. Friedman, M. L. Lachenmayer, J. Wang, L. He, S. M. Poulose et al., Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of ??-Synuclein and LRRK2 in the Brain, Journal of Neuroscience, vol.32, issue.22, pp.7585-7593, 2012.
DOI : 10.1523/JNEUROSCI.5809-11.2012

K. A. Fujita, M. Ostaszewski, Y. Matsuoka, S. Ghosh, E. Glaab et al., Integrating Pathways of Parkinson's Disease in a Molecular Interaction Map, Molecular Neurobiology, vol.27, issue.Suppl 1, pp.88-102, 2014.
DOI : 10.1007/s12035-013-8489-4

C. Funke, S. A. Schneider, D. Berg, and D. B. Kell, Genetics and iron in the systems biology of Parkinson???s disease and some related disorders, Neurochemistry International, vol.62, issue.5, pp.637-652, 2013.
DOI : 10.1016/j.neuint.2012.11.015

S. Gandhi, . A. Wood-kaczmar, Z. Yao, H. Plun-favreau, E. Deas et al., PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death, Molecular Cell, vol.33, issue.5, pp.627-638, 2009.
DOI : 10.1016/j.molcel.2009.02.013

C. A. Gautier, T. Kitada, and J. Shen, Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress, Proceedings of the National Academy of Sciences, vol.105, issue.32, pp.11364-11369, 2008.
DOI : 10.1073/pnas.0802076105

S. Geisler, K. M. Holmström, D. Skujat, F. C. Fiesel, O. C. Rothfuss et al., PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1, Nature Cell Biology, vol.278, issue.2, pp.119-131, 2010.
DOI : 10.1038/ncb2012

S. Janezic, S. Threlfell, P. D. Dodson, M. J. Dowie, T. N. Taylor et al., Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model, Proc. Natl. Acad. Sci. U S A, pp.4016-4025, 2013.
DOI : 10.1073/pnas.1309143110

P. Jenner and C. W. Olanow, Oxidative stress and the pathogenesis of Parkinson's disease, Neurology, vol.47, issue.Issue 6, Supplement 3, pp.161-70, 1996.
DOI : 10.1212/WNL.47.6_Suppl_3.161S

F. Kamp, N. Exner, A. K. Lutz, N. Wender, J. Hegermann et al., Inhibition of mitochondrial fusion by ??-synuclein is rescued by PINK1, Parkin and DJ-1, The EMBO Journal, vol.1193, issue.20, pp.3571-3589, 2010.
DOI : 10.1038/emboj.2010.223

C. Kim, L. , and S. J. , Controlling the mass action of alphasynuclein in Parkinson's disease, 2008.

R. H. Kim, P. D. Smith, H. Aleyasin, S. Hayley, M. P. Mount et al., Hypersensitivity of DJ-1-deficient mice to 1-methyl-4, MPTP) and oxidative stress. Proc. Natl. Acad. Sci. USA, pp.6-5215, 2003.

J. W. Langston, E. B. Langston, I. , and I. , MPTP-induced parkinsonism in human and nonhuman primates -clinical and experimental aspects, Acta Neurol Scand, vol.100, pp.49-54, 1984.

A. Lannuzel, M. Ruberg, M. , and P. P. , Atypical parkinsonism in the Caribbean island of Guadeloupe: Etiological role of the mitochondrial complex I inhibitor annonacin, Movement Disorders, vol.48, issue.15, pp.2122-2128, 2008.
DOI : 10.1002/mds.22300

H. A. Lashuel, C. R. Overk, A. Oueslati, and E. Masliah, The many faces of ??-synuclein: from structure and toxicity to therapeutic target, Nature Reviews Neuroscience, vol.418, issue.1, pp.38-48, 2013.
DOI : 10.1038/nrn3406

C. Lausted, I. Lee, Y. Zhou, S. Qin, J. Sung et al., Systems Approach to Neurodegenerative Disease Biomarker Discovery, Annual Review of Pharmacology and Toxicology, vol.54, issue.1, pp.457-481, 2014.
DOI : 10.1146/annurev-pharmtox-011613-135928

J. R. Mazzulli, Y. H. Xu, Y. Sun, A. L. Knight, P. J. Mclean et al., Gaucher Disease Glucocerebrosidase and ??-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies, Cell, vol.146, issue.1, pp.37-52, 2011.
DOI : 10.1016/j.cell.2011.06.001

A. Mcneill, J. Magalhaes, C. Shen, K. Chau, D. Hughes et al., Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells, Brain, vol.137, issue.5, pp.1481-1495, 2014.
DOI : 10.1093/brain/awu020

P. P. Michel and F. Hefti, Toxicity of 6-hydroxydopamine and dopamine for dopaminergic neurons in culture, Journal of Neuroscience Research, vol.17, issue.4, pp.428-435, 1990.
DOI : 10.1002/jnr.490260405

P. P. Michel, D. Toulorge, S. Guerreiro, H. , and E. C. , Specific needs of dopamine neurons for stimulation in order to survive: implication for Parkinson disease, The FASEB Journal, vol.27, issue.9, pp.3414-3423, 2013.
DOI : 10.1096/fj.12-220418

Y. Mizuno, S. Ikebe, N. Hattori, Y. Nakagawa-hattori, H. Mochizuki et al., Role of mitochondria in the etiology and pathogenesis of Parkinson's disease, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1271, issue.1, pp.265-274, 1995.
DOI : 10.1016/0925-4439(95)00038-6

K. E. Murphy, L. Cottle, A. M. Gysbers, A. A. Cooper, and G. M. Halliday, ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies, Acta Neuropathologica Communications, vol.1, issue.1, p.11, 2013.
DOI : 10.1016/S1474-4422(09)70238-8

K. E. Murphy, A. M. Gysbers, S. K. Abbott, N. Tayebi, W. S. Kim et al., Reduced glucocerebrosidase is associated with increased ??-synuclein in sporadic Parkinson's disease, Brain, vol.137, issue.3, pp.834-882, 2014.
DOI : 10.1093/brain/awt367

K. Nakamura, V. M. Nemani, F. Azarbal, G. Skibinski, J. M. Levy et al., Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein ??-Synuclein, Journal of Biological Chemistry, vol.286, issue.23, pp.20710-20736, 2011.
DOI : 10.1074/jbc.M110.213538

D. P. Narendra, S. M. Jin, A. Tanaka, D. F. Suen, C. A. Gautier et al., PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin, PLoS Biology, vol.126, issue.1, 2010.
DOI : 10.1371/journal.pbio.1000298.s013

M. Subramaniam, D. Althof, S. Gispert, J. Schwenk, G. Auburger et al., Mutant ??-Synuclein Enhances Firing Frequencies in Dopamine Substantia Nigra Neurons by Oxidative Impairment of A-Type Potassium Channels, Journal of Neuroscience, vol.34, issue.41, pp.13586-99, 2014.
DOI : 10.1523/JNEUROSCI.5069-13.2014

A. Sugiura, G. L. Mclelland, E. A. Fon, and H. M. Mcbride, A new pathway for mitochondrial quality control: mitochondrial-derived vesicles, The EMBO Journal, vol.33, issue.19, pp.2142-2156, 2014.
DOI : 10.15252/embj.201488104

D. Jr, R. E. , P. , and W. D. Jr, Origin and functional consequences of the complex I defect in Parkinson's disease, Ann. Neurol, vol.40, pp.663-671, 1996.

M. Szelechowski, A. Bétourné, Y. Monnet, C. A. Ferré, A. Thouard et al., A viral peptide that targets mitochondria protects against neuronal degeneration in models of Parkinson???s disease, Nature Communications, vol.18, p.5181, 2014.
DOI : 10.1006/neur.1996.0041

S. W. Tait and D. R. Green, Mitochondrial Regulation of Cell Death, Cold Spring Harbor Perspectives in Biology, vol.5, issue.9, p.8706, 2013.
DOI : 10.1101/cshperspect.a008706

A. Tanaka, M. M. Cleland, S. Xu, D. P. Narendra, D. F. Suen et al., Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin, The Journal of Cell Biology, vol.19, issue.7, 2010.
DOI : 10.1083/jcb.201007013.dv

F. L. Tang, J. R. Erion, Y. Tian, W. Liu, D. M. Yin et al., VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for ??-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease, Journal of Neuroscience, vol.35, issue.29, pp.10613-10628, 2015.
DOI : 10.1523/JNEUROSCI.0042-15.2015

M. Y. Teo, M. Van-wyk, J. Lin, and J. Lipski, Differential effects of nicotine on the activity of substantia nigra and ventral tegmental area dopaminergic neurons in vitro, Acta Neurobiol. Exp, vol.64, pp.119-130, 2004.

K. J. Thomas, M. K. Mccoy, J. Blackinton, A. Beilina, M. Van-der-brug et al., DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy, Human Molecular Genetics, vol.20, issue.1, pp.40-50, 2011.
DOI : 10.1093/hmg/ddq430

E. Tsika, L. Glauser, R. Moser, A. Fiser, G. Daniel et al., Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration, Human Molecular Genetics, vol.23, issue.17, pp.4621-4238, 2014.
DOI : 10.1093/hmg/ddu178

T. Tyson, J. A. Steiner, and P. Brundin, Sorting out release, uptake and processing of alpha-synuclein during prion-like spread of pathology, Journal of Neurochemistry, vol.89, 2015.
DOI : 10.1111/jnc.13449

J. Ugolino, S. Fang, C. Kubisch, and M. J. Monteiro, Mutant Atp13a2 proteins involved in parkinsonism are degraded by ER-associated degradation and sensitize cells to ER-stress induced cell death, Human Molecular Genetics, vol.20, issue.18, pp.3565-3577, 2011.
DOI : 10.1093/hmg/ddr274

M. Usenovic and D. Krainc, Lysosomal dysfunction in neurodegeneration, Autophagy, vol.8, issue.6, pp.987-988, 2012.
DOI : 10.4161/auto.20256

V. S. Van-laar and S. B. Berman, The interplay of neuronal mitochondrial dynamics and bioenergetics: Implications for Parkinson's disease, Neurobiology of Disease, vol.51, pp.43-55, 2013.
DOI : 10.1016/j.nbd.2012.05.015

B. D. Van-rooijen, M. M. Claessens, and V. Subramaniam, Membrane Permeabilization by Oligomeric ??-Synuclein: In Search of the Mechanism, PLoS ONE, vol.28, issue.12, 2010.
DOI : 10.1371/journal.pone.0014292.s001

P. Verstreken, C. V. Ly, K. J. Venken, T. W. Koh, Y. Zhou et al., Synaptic Mitochondria Are Critical for Mobilization of Reserve Pool Vesicles at Drosophila Neuromuscular Junctions, Neuron, vol.47, issue.3, pp.365-378, 2005.
DOI : 10.1016/j.neuron.2005.06.018

C. Vilariño-güell, C. Wider, O. A. Ross, J. C. Dachsel, J. M. Kachergus et al., VPS35 Mutations in Parkinson Disease, The American Journal of Human Genetics, vol.89, issue.1, pp.162-169, 2011.
DOI : 10.1016/j.ajhg.2011.06.001

C. Vives-bauza, C. Zhou, Y. Huang, M. Cui, R. L. De-vries et al., PINK1-dependent recruitment of Parkin to mitochondria in mitophagy, Proceedings of the National Academy of Sciences, vol.107, issue.1, pp.378-383, 2010.
DOI : 10.1073/pnas.0911187107

X. Wang, D. Winter, G. Ashrafi, J. Schlehe, Y. L. Wong et al., PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility, Cell, vol.147, issue.4, pp.893-906, 2011.
DOI : 10.1016/j.cell.2011.10.018

B. Winner, R. Jappelli, S. K. Maji, P. A. Desplats, L. Boyer et al., In vivo demonstration that alpha-synuclein oligomers are toxic, Proc. Natl. Acad. Sci. U S A, pp.4194-4199, 2011.

A. R. Winslow, C. W. Chen, S. Corrochano, A. Acevedo-arozena, D. E. Gordon et al., ??-Synuclein impairs macroautophagy: implications for Parkinson???s disease, The Journal of Cell Biology, vol.190, issue.6, pp.1023-1037, 2010.
DOI : 10.1083/jcb.201003122.dv

J. Wolfart, H. Neuhoff, O. Franz, and J. Roeper, Differential expression of the smallconductance , calcium-activated potassium channel SK3 is critical for pacemaker control in dopaminergic midbrain neurons, J Neurosci, vol.21, pp.3443-3456, 2001.

M. Xilouri, T. Vogiatzi, K. Vekrellis, D. Park, and L. Stefanis, Abberant ??-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy, PLoS ONE, vol.22, issue.5, p.5515, 2009.
DOI : 10.1371/journal.pone.0005515.s005

T. L. Yap, A. Velayati, E. Sidransky, L. , and J. C. , Membrane-bound ??-synuclein interacts with glucocerebrosidase and inhibits enzyme activity, Molecular Genetics and Metabolism, vol.108, issue.1, pp.56-64, 2013.
DOI : 10.1016/j.ymgme.2012.11.010

A. G. Yee, S. M. Lee, M. R. Hunter, M. Glass, P. S. Freestone et al., Effects of the Parkinsonian toxin MPP+ on electrophysiological properties of nigral dopaminergic neurons, NeuroToxicology, vol.45, pp.1-11, 2014.
DOI : 10.1016/j.neuro.2014.08.009

R. J. Youle and A. M. Van-der-bliek, Mitochondrial Fission, Fusion, and Stress, Science, vol.337, issue.6098, pp.1062-1065, 2012.
DOI : 10.1126/science.1219855

Y. Yuan, P. Cao, M. A. Smith, K. Kramp, Y. Huang et al., Dysregulated LRRK2 Signaling in Response to Endoplasmic Reticulum Stress Leads to Dopaminergic Neuron Degeneration in C. elegans, PLoS ONE, vol.27, issue.8, 2011.
DOI : 10.1371/journal.pone.0022354.s008

A. Zimprich, A. Benet-pagès, W. Struhal, E. Graf, S. H. Eck et al., A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease, The American Journal of Human Genetics, vol.89, issue.1, pp.168-175, 2011.
DOI : 10.1016/j.ajhg.2011.06.008