Leptin-regulated endocannabinoids are involved in maintaining food intake, Nature, vol.410, issue.6830, pp.822-825, 2001. ,
DOI : 10.1038/35071088
Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats, British Journal of Pharmacology, vol.143, issue.6, pp.1151-1154, 2001. ,
DOI : 10.1038/sj.bjp.0704379
Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors, Psychopharmacology, vol.143, issue.3, pp.315-317, 1999. ,
DOI : 10.1007/s002130050953
Rimonabant for overweight or obesity, Cochrane Database Syst Rev, vol.273, issue.4, p.6162, 2006. ,
DOI : 10.1002/14651858.CD006162.pub2
Drug treatments for obesity: orlistat, sibutramine, and rimonabant, The Lancet, vol.369, issue.9555, pp.71-77, 2007. ,
DOI : 10.1016/S0140-6736(07)60033-6
Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats, Hepatology, vol.330, issue.1, pp.122-129, 2007. ,
DOI : 10.1002/hep.21641
The anti-obesity effect of rimonabant is associated with an improved serum lipid profile, Diabetes, Obesity and Metabolism, vol.103, issue.1, pp.65-72, 2005. ,
DOI : 10.1074/jbc.M209033200
Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, vol.284, issue.2, pp.345-353, 2003. ,
DOI : 10.1152/ajpregu.00545.2002
Effects of Rimonabant on Metabolic Risk Factors in Overweight Patients with Dyslipidemia, New England Journal of Medicine, vol.353, issue.20, pp.2121-2134, 2005. ,
DOI : 10.1056/NEJMoa044537
Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study, The Lancet, vol.365, issue.9468, pp.1389-1397, 2005. ,
DOI : 10.1016/S0140-6736(05)66374-X
Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials, The Lancet, vol.370, issue.9600, pp.1706-1713, 2007. ,
DOI : 10.1016/S0140-6736(07)61721-8
CB1 antagonists for obesity???what lessons have we learned from rimonabant?, Nature Reviews Endocrinology, vol.14, issue.11, pp.633-638, 2009. ,
DOI : 10.1038/nrendo.2009.197
CB1 Antagonism Exerts Specific Molecular Effects on Visceral and Subcutaneous Fat and Reverses Liver Steatosis in Diet-Induced Obese Mice, Diabetes, vol.59, issue.4, pp.926-934, 2010. ,
DOI : 10.2337/db09-1482
URL : https://hal.archives-ouvertes.fr/inserm-01344504
Endogenous cannabinoids in the brain and peripheral tissues: regulation of their levels and control of food intake, International Journal of Obesity, vol.258, issue.1, pp.7-12, 2006. ,
DOI : 10.1038/nn1457
Peripheral, but Not Central, CB1 Antagonism Provides Food Intake-Independent Metabolic Benefits in Diet-Induced Obese Rats, Diabetes, vol.57, issue.11, pp.2977-2991, 2008. ,
DOI : 10.2337/db08-0161
Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice, Journal of Clinical Investigation, vol.118, issue.9, pp.3160-3169, 2008. ,
DOI : 10.1172/JCI34827
Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity, Journal of Clinical Investigation, vol.120, issue.8, pp.2953-2966, 2010. ,
DOI : 10.1172/JCI42551DS1
Different effects of pioglitazone and rosiglitazone on lipid metabolism in mouse cultured liver explants, Diabetes/Metabolism Research and Reviews, vol.277, issue.Pt 3, pp.297-305, 2010. ,
DOI : 10.1002/dmrr.1081
A simple method for the isolation and purification of total lipides from animal tissues, J Biol Chem, vol.226, pp.497-509, 1957. ,
Effect of dietary n???3 and n???6 polyunsaturated fatty acids on lipid-metabolizing enzymes in obese rat liver, Lipids, vol.38, issue.7, pp.481-489, 1994. ,
DOI : 10.1007/BF02578245
Liver Carbohydrate and Lipid Metabolism of Insulin-Deficient Mice Is Altered by trans-10, cis-12 Conjugated Linoleic Acid, Journal of Nutrition, vol.139, issue.10, pp.1901-1907, 2009. ,
DOI : 10.3945/jn.109.111062
Conjugated linoleic acid isomers in mitochondria: evidence for an alteration of fatty acid oxidation, The Journal of Lipid Research, vol.43, issue.12, pp.2112-2122, 2002. ,
DOI : 10.1194/jlr.M200170-JLR200
Upregulation of liver VLDL receptor and FAT/CD36 expression in LDLR-/- apoB100/100 mice fed trans-10,cis-12 conjugated linoleic acid, The Journal of Lipid Research, vol.47, issue.12, pp.2647-2655, 2006. ,
DOI : 10.1194/jlr.M600140-JLR200
Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth, The FASEB Journal, vol.15, pp.2745-2747, 2001. ,
DOI : 10.1096/fj.01-0320fje
Transcriptional Regulation of Cannabinoid Receptor-1 Expression in the Liver by Retinoic Acid Acting via Retinoic Acid Receptor-??, Journal of Biological Chemistry, vol.285, issue.25, pp.19002-19011, 2010. ,
DOI : 10.1074/jbc.M109.068460
Reduction of Hepatic Glucose Production as a Therapeutic Target in the Treatment of Diabetes, Current Drug Targets - Immune, Endocrine & Metabolic Disorders, vol.5, issue.1, pp.51-59, 2005. ,
DOI : 10.2174/1568008053174769
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity, Journal of Clinical Investigation, vol.115, issue.5, pp.1298-1305, 2005. ,
DOI : 10.1172/JCI200523057
Transcriptional induction of glucokinase gene by insulin in cultured liver cells and its repression by the glucagon-cAMP system, J Biol Chem, vol.264, pp.21824-21829, 1989. ,
Rat glucokinase gene: structure and regulation by insulin., Proceedings of the National Academy of Sciences, vol.86, issue.13, pp.4838-4842, 1989. ,
DOI : 10.1073/pnas.86.13.4838
Glucose 6-phosphate produced by glucokinase, but not hexokinase I, promotes the activation of hepatic glycogen synthase, J Biol Chem, vol.271, pp.23756-23760, 1996. ,
Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes, Proceedings of the National Academy of Sciences, vol.96, issue.22, pp.12737-12742, 1999. ,
DOI : 10.1073/pnas.96.22.12737
MECHANISMS BY WHICH CARBOHYDRATES REGULATE EXPRESSION OF GENES FOR GLYCOLYTIC AND LIPOGENIC ENZYMES, Annual Review of Nutrition, vol.17, issue.1, pp.325-352, 1997. ,
DOI : 10.1146/annurev.nutr.17.1.325
Evidence for post-transcriptional regulation by insulin of 3-hydroxy-3-methylglutaryl coenzyme A reductase and sterol synthesis in human mononuclear leucocytes, Diabetologia, vol.26, issue.5, pp.366-369, 1984. ,
DOI : 10.1007/BF00266038
Regulation of porcine granulosa cell 3-hydroxy-3-methylglutaryl coenzyme A reductase by insulin and insulin-like growth factor I: synergism with follicle-stimulating hormone or protein kinase A agonist, Endocrinology, vol.136, pp.5111-5117, 1995. ,
Phosphatidylinositol-3-Kinase Regulates Scavenger Receptor Class B Type I Subcellular Localization and Selective Lipid Uptake in Hepatocytes, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.26, issue.9, pp.2125-2131, 2006. ,
DOI : 10.1161/01.ATV.0000233335.26362.37
Santamarina-Fojo S. Hepatic lipase promotes the selective uptake of high density lipoprotein-cholesteryl esters via the scavenger receptor B1, J Lipid Res, vol.40, pp.1294-1303, 1999. ,
Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids., Journal of Clinical Investigation, vol.99, issue.10, pp.2416-2422, 1997. ,
DOI : 10.1172/JCI119424
Hepatic lipase: structure/function relationship, synthesis, and regulation, J Lipid Res, vol.43, pp.1163-1169, 2002. ,
Cannabinoid 1 Receptor Blockade Reduces Atherosclerosis with Enhances Reverse Cholesterol Transport, Journal of Atherosclerosis and Thrombosis, vol.17, issue.2, pp.141-147, 2010. ,
DOI : 10.5551/jat.2865
Hepatic carnitine palmitoyltransferase-I has two independent inhibitory binding sites for regulation of fatty acid oxidation, Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol.1212, issue.2, pp.245-252, 1994. ,
DOI : 10.1016/0005-2760(94)90259-3
Malonyl-CoA binding site and the overt carnitine palmitoyltransferase activity reside on the opposite sides of the outer mitochondrial membrane., Proceedings of the National Academy of Sciences, vol.84, issue.2, pp.378-382, 1987. ,
DOI : 10.1073/pnas.84.2.378
Regulation of acetyl-CoA carboxylase: Table 1, Biochemical Society Transactions, vol.34, issue.2, pp.223-227, 2006. ,
DOI : 10.1042/BST0340223
Rimonabant Ameliorates Insulin Resistance via both Adiponectin-dependent and Adiponectin-independent Pathways, Journal of Biological Chemistry, vol.284, issue.3, pp.1803-1812, 2009. ,
DOI : 10.1074/jbc.M807120200
Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance., Journal of Clinical Investigation, vol.84, issue.1, pp.205-213, 1989. ,
DOI : 10.1172/JCI114142
Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver, Proceedings of the National Academy of Sciences, vol.108, issue.15, pp.6323-6328, 2011. ,
DOI : 10.1073/pnas.1017689108
A Selective Inverse Agonist for Central Cannabinoid Receptor Inhibits Mitogen-activated Protein Kinase Activation Stimulated by Insulin or Insulin-like Growth Factor 1: EVIDENCE FOR A NEW MODEL OF RECEPTOR/LIGAND INTERACTIONS, Journal of Biological Chemistry, vol.272, issue.35, pp.22330-22339, 1997. ,
DOI : 10.1074/jbc.272.35.22330
Inhibitory effects of SR141716A on G-protein activation in rat brain, European Journal of Pharmacology, vol.414, issue.2-3, pp.135-143, 2001. ,
DOI : 10.1016/S0014-2999(01)00784-1
The Cannabinoid CB1 Receptor Antagonist Rimonabant Stimulates 2-Deoxyglucose Uptake in Skeletal Muscle Cells by Regulating the Expression of Phosphatidylinositol-3-kinase, Molecular Pharmacology, vol.74, issue.6, pp.1678-1686, 2008. ,
DOI : 10.1124/mol.108.049205