The role of the glucose-sensing transcription factor carbohydrate-responsive element-binding protein pathway in termite queen fertility.

Abstract : Termites are among the few animals that themselves can digest the most abundant organic polymer, cellulose, into glucose. In mice and Drosophila, glucose can activate genes via the transcription factor carbohydrate-responsive element-binding protein (ChREBP) to induce glucose utilization and de novo lipogenesis. Here, we identify a termite orthologue of ChREBP and its downstream lipogenic targets, including acetyl-CoA carboxylase and fatty acid synthase. We show that all of these genes, including ChREBP, are upregulated in mature queens compared with kings, sterile workers and soldiers in eight different termite species. ChREBP is expressed in several tissues, including ovaries and fat bodies, and increases in expression in totipotent workers during their differentiation into neotenic mature queens. We further show that ChREBP is regulated by a carbohydrate diet in termite queens. Suppression of the lipogenic pathway by a pharmacological agent in queens elicits the same behavioural alterations in sterile workers as observed in queenless colonies, supporting that the ChREBP pathway partakes in the biosynthesis of semiochemicals that convey the signal of the presence of a fertile queen. Our results highlight ChREBP as a likely key factor for the regulation and signalling of queen fertility.
Type de document :
Article dans une revue
Open Biology, Royal Society, 2016, 6 (5), 〈10.1098/rsob.160080〉
Liste complète des métadonnées

Littérature citée [76 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-01335683
Contributeur : Mireille Bos <>
Soumis le : mercredi 22 juin 2016 - 11:17:18
Dernière modification le : vendredi 26 janvier 2018 - 18:26:01
Document(s) archivé(s) le : vendredi 23 septembre 2016 - 12:55:53

Fichier

160080.full.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

Citation

David Sillam-Dussès, Robert Hanus, Michael Poulsen, Virginie Roy, Maryline Favier, et al.. The role of the glucose-sensing transcription factor carbohydrate-responsive element-binding protein pathway in termite queen fertility.. Open Biology, Royal Society, 2016, 6 (5), 〈10.1098/rsob.160080〉. 〈inserm-01335683〉

Partager

Métriques

Consultations de la notice

141

Téléchargements de fichiers

55