Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma. Cancer research, pp.7385-7392, 2009. ,
Wnt-pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib. Clinical cancer research, pp.4997-5007, 2012. ,
Wnt/??-Catenin Signaling and Disease, Cell, vol.149, issue.6, pp.1192-1205, 2012. ,
DOI : 10.1016/j.cell.2012.05.012
Signaling pathway cooperation in TGF-beta-induced epithelialmesenchymal transition. Current opinion in cell biology, pp.56-66, 2014. ,
Network modeling of TGFbeta signaling in hepatocellular carcinoma epithelialto-mesenchymal transition reveals joint sonic hedgehog and Wnt pathway activation. Cancer research, pp.5963-5977, 2014. ,
Wnt signaling and hepatocarcinogenesis: Molecular targets for the development of innovative anticancer drugs, Journal of Hepatology, vol.59, issue.5, pp.1107-1117, 2013. ,
DOI : 10.1016/j.jhep.2013.07.001
Secreted frizzled related proteins: Implications in cancers, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol.1845, issue.1, pp.53-65, 2014. ,
DOI : 10.1016/j.bbcan.2013.11.004
A Cryptic Frizzled Module in Cell Surface Collagen 18 Inhibits Wnt/?????Catenin Signaling, PLoS ONE, vol.98, issue.4, p.1878, 2008. ,
DOI : 10.1371/journal.pone.0001878.s006
Inhibition of Wnt/??-Catenin Signaling by a Soluble Collagen-Derived Frizzled Domain Interacting with Wnt3a and the Receptors Frizzled 1 and 8, PLoS ONE, vol.29, issue.1, p.30601, 2012. ,
DOI : 10.1371/journal.pone.0030601.s009
URL : https://hal.archives-ouvertes.fr/hal-00866379
Blocking Wnt signaling by SFRP-like molecules inhibits in vivo cell proliferation and tumor growth in cells carrying active ??-catenin, Oncogene, vol.281, issue.4, pp.423-433, 2011. ,
DOI : 10.1038/onc.2010.432
URL : https://hal.archives-ouvertes.fr/inserm-00522121
Blockade of Wnt Signaling Inhibits Angiogenesis and Tumor Growth in Hepatocellular Carcinoma, Cancer Research, vol.69, issue.17, pp.6951-6959, 2009. ,
DOI : 10.1158/0008-5472.CAN-09-0541
Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma, New England Journal of Medicine, vol.359, issue.19, pp.1995-2004, 2008. ,
DOI : 10.1056/NEJMoa0804525
Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver, Cell, vol.160, issue.1-2, pp.299-312, 2015. ,
DOI : 10.1016/j.cell.2014.11.050
Wnt proteins are lipid-modified and can act as stem cell growth factors, Nature, vol.367, issue.6938, pp.448-452, 2003. ,
DOI : 10.1084/jem.192.12.1707
Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity, BMC Biology, vol.12, issue.1, p.44, 2014. ,
DOI : 10.1002/prot.340230412
Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor, Hepatology, vol.103, issue.4, pp.957-967, 2007. ,
DOI : 10.1002/hep.21536
URL : https://hal.archives-ouvertes.fr/hal-00690471
Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells, Hepatology, vol.58, issue.2, pp.700-714, 2014. ,
DOI : 10.1002/hep.27165
URL : https://hal.archives-ouvertes.fr/hal-01169803
Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells, Hepatology, vol.7, issue.29, pp.2077-2090, 2014. ,
DOI : 10.1002/hep.27353
URL : https://hal.archives-ouvertes.fr/hal-01134747
Mice lacking link protein develop dwarfism and craniofacial abnormalities, Nature genetics, vol.21, pp.225-229, 1999. ,
The Different Roles of Aggrecan Interaction Domains, Journal of Histochemistry & Cytochemistry, vol.8, issue.3, pp.987-996, 2012. ,
DOI : 10.1242/dev.030742
Next generation software for functional trend analysis, Bioinformatics, vol.25, issue.22, pp.3043-3044, 2009. ,
DOI : 10.1093/bioinformatics/btp498
Multiple effects of electroporation on the adhesive behaviour of breast cancer cells and fibroblasts, Cancer Cell International, vol.12, issue.1, p.9, 2012. ,
DOI : 10.1091/mbc.E04-04-0353
A Human Model of Epithelial to Mesenchymal Transition to Monitor Drug Efficacy in Hepatocellular Carcinoma Progression, Molecular Cancer Therapeutics, vol.10, issue.5, pp.850-860, 2011. ,
DOI : 10.1158/1535-7163.MCT-10-0917
An expression atlas of human primary cells: inference of gene function from coexpression networks, BMC Genomics, vol.14, issue.1, p.632, 2013. ,
DOI : 10.1038/ni.2516
The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor www.impactjournals.com/oncotarget extracellular matrices, Mol Cell Proteomics, vol.11, pp.111-014647, 2012. ,
Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells, Proceedings of the National Academy of Sciences, vol.107, issue.31, pp.13742-13747, 2010. ,
DOI : 10.1073/pnas.1002077107
DACH1 is a novel predictive and prognostic biomarker in hepatocellular carcinoma as a negative regulator of Wnt/??-catenin signaling, Oncotarget, vol.6, issue.11, pp.8621-8634, 2015. ,
DOI : 10.18632/oncotarget.3281
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration, Nature, vol.422, issue.7436, pp.247-250, 2013. ,
DOI : 10.1038/nature11826
Notch and Wnt/beta-catenin signaling pathway play important roles in activating liver cancer stem cells, Oncotarget, vol.7, pp.5754-5768, 2016. ,
G-Protein-Coupled Receptor GPR49 is Up-regulated in Basal Cell Carcinoma and Promotes Cell Proliferation and Tumor Formation, The American Journal of Pathology, vol.173, issue.3, pp.835-843, 2008. ,
DOI : 10.2353/ajpath.2008.071091
Lin28b Is Sufficient to Drive Liver Cancer and Necessary for Its Maintenance in Murine Models, Cancer Cell, vol.26, issue.2, pp.248-261, 2014. ,
DOI : 10.1016/j.ccr.2014.06.018
The Four and a Half LIM-Domain 2 Controls Early Cardiac Cell Commitment and Expansion Via Regulating ??-Catenin-Dependent Transcription, STEM CELLS, vol.109, issue.5, pp.928-940, 2013. ,
DOI : 10.1002/stem.1332
The Emerging Role of Insulin and Insulin-Like Growth Factor Signaling in Cancer Stem Cells, Frontiers in Endocrinology, vol.5, p.10, 2014. ,
DOI : 10.3389/fendo.2014.00010
The Membrane-Associated Adaptor Protein DOK5 Is Upregulated in Systemic Sclerosis and Associated with IGFBP-5-Induced Fibrosis, PLoS ONE, vol.48, issue.2, p.87754, 2014. ,
DOI : 10.1371/journal.pone.0087754.t002
EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features, Gastroenterology, vol.136, issue.3, pp.1012-1024, 2009. ,
DOI : 10.1053/j.gastro.2008.12.004
Spatial transcriptional profile of the chick and mouse endocardial cushions identify novel regulators of endocardial EMT in vitro, Journal of Molecular and Cellular Cardiology, vol.59, pp.196-204, 2013. ,
DOI : 10.1016/j.yjmcc.2013.03.016
The CAP Superfamily: Cysteine-Rich Secretory Proteins, Antigen 5, and Pathogenesis-Related 1 Proteins???Roles in Reproduction, Cancer, and Immune Defense, Endocrine Reviews, vol.29, issue.7, pp.865-897, 2008. ,
DOI : 10.1210/er.2008-0032
PETALS: Proteomic Evaluation and Topological Analysis of a mutated Locus' Signaling, BMC Bioinformatics, vol.11, issue.1, p.596, 2010. ,
DOI : 10.1186/1471-2105-11-596
Protumorigenic role of HAPLN1 and its IgV domain in malignant pleural mesothelioma. Clinical cancer research : an official journal of the American Association for Cancer Research, pp.2602-2611, 2009. ,
Somatic mutations of the ??-catenin gene are frequent in mouse and human hepatocellular carcinomas, Proceedings of the National Academy of Sciences, vol.95, issue.15, pp.8847-8851, 1998. ,
DOI : 10.1073/pnas.95.15.8847
REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms, PLoS ONE, vol.6, issue.7, p.21800, 2011. ,
DOI : 10.1371/journal.pone.0021800.t001
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles, Proceedings of the National Academy of Sciences, vol.102, issue.43, pp.15545-15550, 2005. ,
DOI : 10.1073/pnas.0506580102
The sva package for removing batch effects and other unwanted variation in high-throughput experiments, Bioinformatics, vol.28, issue.6, pp.882-883, 2012. ,
DOI : 10.1093/bioinformatics/bts034
WGCNA: an R package for weighted correlation network analysis, BMC Bioinformatics, vol.9, issue.1, p.559, 2008. ,
DOI : 10.1186/1471-2105-9-559
Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK), JNCI Journal of the National Cancer Institute, vol.97, issue.16, pp.1180-1184, 2005. ,
DOI : 10.1093/jnci/dji237