Luteolin Impacts on the DNA Damage Pathway in Oral Squamous Cell Carcinoma.

Abstract : Oral squamous cell carcinoma (OSCC) exhibited high chemoresistance to current treatments. Here we aimed at identifying and repositioning approved drugs that could be selectively toxic toward OSCC cells. Through a cell-based drug screening of 1,280 chemical molecules, we selected compounds lethal to oral cancer SCC-25 cells, while sparing normal keratinocyte HaCaT cells. Within the chemical library, the natural flavonoid luteolin was identified as a potent cytotoxic agent against oral cancer cells in vitro, along with metixene hydrochloride and nitazoxanide. Of note, they exhibit low toxicity and high efficiency compared to the standard-of-care, such as cisplatin and the epidermal growth factor receptor inhibitor tyrphostin. From a molecular standpoint, luteolin causes phosphorylation of ataxia telangiectasia mutated (ATM) and H2AX in a DNA repair pathway and can be efficiently combined with a checkpoint kinase (CHK) pharmacological inhibitor. Thus, luteolin emerges as a potent cytotoxic and/or adjuvant therapy in oral cancer, as it is a natural compound presenting better effects in vitro compared to conventional chemotherapeutic agents. Future in vivo exploration is next required to provide the proof-of-concept that luteolin could be an efficient anticancer molecule.
Type de document :
Article dans une revue
Nutrition and Cancer, Taylor & Francis (Routledge), 2016, pp.1-10. 〈10.1080/01635581.2016.1180411〉
Liste complète des métadonnées

Littérature citée [54 références]  Voir  Masquer  Télécharger
Contributeur : Elizabeth Bernardo <>
Soumis le : lundi 20 juin 2016 - 10:05:43
Dernière modification le : jeudi 15 mars 2018 - 14:10:54
Document(s) archivé(s) le : jeudi 22 septembre 2016 - 19:48:17


 Accès restreint
Fichier visible le : jamais

Connectez-vous pour demander l'accès au fichier




Kellen Cristine Tjioe, Denise Tostes Oliveira, Julie Gavard. Luteolin Impacts on the DNA Damage Pathway in Oral Squamous Cell Carcinoma.. Nutrition and Cancer, Taylor & Francis (Routledge), 2016, pp.1-10. 〈10.1080/01635581.2016.1180411〉. 〈inserm-01333887〉



Consultations de la notice