Relevance of Endoplasmic Reticulum Stress Cell Signaling in Liver Cold Ischemia Reperfusion Injury

Abstract : The endoplasmic reticulum (ER) is involved in calcium homeostasis, protein folding and lipid biosynthesis. Perturbations in its normal functions lead to a condition called endoplasmic reticulum stress (ERS). This can be triggered by many physiopathological conditions such as alcoholic steatohepatitis, insulin resistance or ischemia-reperfusion injury. The cell reacts to ERS by initiating a defensive process known as the unfolded protein response (UPR), which comprises cellular mechanisms for adaptation and the safeguarding of cell survival or, in cases of excessively severe stress, for the initiation of the cell death program. Recent experimental data suggest the involvement of ERS in ischemia/reperfusion injury (IRI) of the liver graft, which has been considered as one of major problems influencing outcome after liver transplantation. The purpose of this review is to summarize updated data on the molecular mechanisms of ERS/UPR and the consequences of this pathology, focusing specifically on solid organ preservation and liver transplantation models. We will also discuss the potential role of ERS, beyond the simple adaptive response and the regulation of cell death, in the modification of cell functional properties and phenotypic changes. Keywords: endoplasmic reticulum stress; unfolded protein response; liver ischemia reperfusion injury; orthotopic liver transplantation; University Wisconsin (UW) solution; Institut Georges Lopez-1 (IGL-1) solution
Type de document :
Article dans une revue
International Journal of Molecular Sciences, MDPI, 2016, 17 (6), 〈10.3390/ijms17060807〉
Liste complète des métadonnées

Littérature citée [56 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-01324400
Contributeur : René Adam <>
Soumis le : mardi 31 mai 2016 - 22:33:40
Dernière modification le : samedi 18 février 2017 - 01:01:15

Fichier

Article ERS.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

Citation

Emma Folch-Puy, Arnau Panisello, Joan Oliva, Alexandre Lopez, Carlos Castro Benítez, et al.. Relevance of Endoplasmic Reticulum Stress Cell Signaling in Liver Cold Ischemia Reperfusion Injury. International Journal of Molecular Sciences, MDPI, 2016, 17 (6), 〈10.3390/ijms17060807〉. 〈inserm-01324400〉

Partager

Métriques

Consultations de la notice

56

Téléchargements de fichiers

68