Staphylococcus aureus Regulatory RNAs as Potential Biomarkers for Bloodstream Infections

Abstract : Staphylococcus aureus is a commensal bacterium and pathogen. Identifying biomarkers for the transition from colonization to disease caused by this organism would be useful. Several S. aureus small RNAs (sRNAs) regulate virulence. We investigated presence and expression of 8 sRNAs in 83 S. aureus strains from 42 patients with sepsis or septic shock and 41 asymptomatic colonized carriers. Small pathogenicity island sRNAs sprB and sprC were clade specific. Six sRNAs had variable expression not correlated with clinical status. Expression of RNAIII was lower in strains from septic shock patients than in strains from colonized patients. When RNAIII was associated with expression of sprD, colonizing strains could be discriminated from strains in patients with bloodstream infections, including patients with sepsis and septic shock. Isolates associated with colonization might have sRNAs with target expression different from those of disease isolates. Monitoring expression of RNAIII and sprD could help determine severity of bloodstream infections.
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Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2016, Emerging Infectious Diseases, 22 (9), pp.1570-1578. <10.3201/eid2209.151801>
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Soumis le : vendredi 27 mai 2016 - 16:25:49
Dernière modification le : jeudi 20 octobre 2016 - 13:55:22

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Valérie Bordeau, Anne Cady, Matthieu Revest, Octavie Rostan, Mohamed Sassi, et al.. Staphylococcus aureus Regulatory RNAs as Potential Biomarkers for Bloodstream Infections. Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2016, Emerging Infectious Diseases, 22 (9), pp.1570-1578. <10.3201/eid2209.151801>. <inserm-01322781>

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