Relevance of internal time and circadian robustness for cancer patients - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue BMC Cancer Année : 2015

Relevance of internal time and circadian robustness for cancer patients

Résumé

AbstractBackgroundAdequate circadian timing of cancer treatment schedules (chronotherapy) can enhance tolerance and efficacy several-fold in experimental and clinical situations. However, the optimal timing varies according to sex, genetic background and lifestyle. Here, we compute the individual phase of the Circadian Timing System to decipher the internal timing of each patient and find the optimal treatment timing.MethodsTwenty-four patients (11 male; 13 female), aged 36 to 77 years, with advanced or metastatic gastro-intestinal cancer were recruited. Inner wrist surface Temperature, arm Activity and Position (TAP) were recorded every 10 min for 12 days, divided into three 4-day spans before, during and after a course of a set chronotherapy schedule. Pertinent indexes, I < O and a new biomarker, DI (degree of temporal internal order maintenance), were computed for each patient and period.ResultsThree circadian rhythms and the TAP rhythm grew less stable and more fragmented in response to treatment. Furthermore, large inter- and intra-individual changes were found for T, A, P and TAP patterns, with phase differences of up to 12 hours among patients. A moderate perturbation of temporal internal order was observed, but the administration of fixed chronomodulated chemotherapy partially resynchronized temperature and activity rhythms by the end of the study.ConclusionsThe integrated variable TAP, together with the asynchrony among rhythms revealed by the new biomarker DI, would help in the personalization of cancer chronotherapy, taking into account individual circadian phase markers.
Fichier principal
Vignette du fichier
12885_2016_Article_2319.pdf (1.57 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

inserm-01322554 , version 1 (27-05-2016)

Identifiants

Citer

Elisabet Ortiz-Tudela, Pasquale F. Innominato, Maria Angeles Rol, Francis Lévi, Juan Antonio Madrid. Relevance of internal time and circadian robustness for cancer patients. BMC Cancer, 2015, 16 (1), pp.285. ⟨10.1186/s12885-016-2319-9⟩. ⟨inserm-01322554⟩
55 Consultations
126 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More