Malaria, New England Journal of Medicine, vol.371, issue.5, pp.411-434, 2014. ,
DOI : 10.1056/NEJMoa1314981
URL : https://hal.archives-ouvertes.fr/inserm-00854378
Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays: retrospective and prospective investigations, BMC Medicine, vol.47, issue.3, p.305, 2015. ,
DOI : 10.1186/s12916-015-0539-5
Artemisinin resistance ??? modelling the potential human and economic costs, Malaria Journal, vol.13, issue.1, p.452, 2014. ,
DOI : 10.1016/S0140-6736(12)60034-8
Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs, Life Sciences, vol.74, issue.16, pp.1957-72, 2004. ,
DOI : 10.1016/j.lfs.2003.10.003
The antimalarial drug artemisinin alkylates heme in infected mice, Proceedings of the National Academy of Sciences, vol.102, issue.38, pp.13676-80, 2005. ,
DOI : 10.1073/pnas.0500972102
Modeling the molecular basis of atovaquone resistance in parasites and pathogenic fungi, Trends in Parasitology, vol.23, issue.10, pp.494-501, 2007. ,
DOI : 10.1016/j.pt.2007.08.004
Mechanisms of Resistance of Malaria Parasites to Antifolates, Pharmacological Reviews, vol.57, issue.1, pp.117-162, 2005. ,
DOI : 10.1124/pr.57.1.4
Chemotherapy of malaria. Geneva: World Health Organization, p.245, 1986. ,
The diminishing returns of atovaquone-proguanil for elimination of Plasmodium falciparum malaria: modelling mass drug administration and treatment, Malaria Journal, vol.13, issue.1, p.380, 2014. ,
DOI : 10.1038/ng.2624
Malaria and Atovaquone-Proguanil Treatment Failure, Emerging Infectious Diseases, vol.14, issue.2, pp.320-322, 2008. ,
DOI : 10.3201/eid1402.070945
Evidence of Artemisinin-Resistant Malaria in Western Cambodia, New England Journal of Medicine, vol.359, issue.24, pp.2619-2639, 2008. ,
DOI : 10.1056/NEJMc0805011
Artemisinin-Resistant Malaria in Asia, New England Journal of Medicine, vol.361, issue.5, pp.540-541, 2009. ,
DOI : 10.1056/NEJMc0900231
Malaria, New England Journal of Medicine, vol.361, issue.5, pp.455-67, 2009. ,
DOI : 10.1056/NEJMoa0808859
URL : https://hal.archives-ouvertes.fr/hal-01199794
Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study, The Lancet, vol.379, issue.9830, pp.1960-1966, 2012. ,
DOI : 10.1016/S0140-6736(12)60484-X
Identification of resistance of Plasmodium falciparum to artesunate-mefloquine combination in an area along the Thai-Myanmar border: integration of clinico-parasitological response, systemic drug exposure, and in vitro parasite sensitivity, Malaria Journal, vol.12, issue.1, p.263, 2013. ,
DOI : 10.1086/507115
Dihydroartemisinin???Piperaquine Failure in Cambodia, New England Journal of Medicine, vol.371, issue.5, pp.484-489, 2014. ,
DOI : 10.1056/NEJMc1403007
Evidence of Plasmodium falciparum Malaria Multidrug Resistance to Artemisinin and Piperaquine in Western Cambodia: Dihydroartemisinin-Piperaquine Open-Label Multicenter Clinical Assessment, Antimicrobial Agents and Chemotherapy, vol.59, issue.8, pp.4719-4745, 2015. ,
DOI : 10.1128/AAC.00835-15
Dihydroartemisinin-piperaquine failure associated with a triple mutant including kelch13 C580Y in Cambodia: an observational cohort study, The Lancet Infectious Diseases, vol.15, issue.6, pp.683-91, 2015. ,
DOI : 10.1016/S1473-3099(15)70049-6
Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta?analysis of individual patient data, BMC Med, vol.13, p.212, 2015. ,
The Origins of Antimalarial-Drug Resistance, New England Journal of Medicine, vol.371, issue.5, pp.397-406, 2014. ,
DOI : 10.1056/NEJMp1403340
The challenge of artemisinin resistance can only be met by eliminating Plasmodium falciparum malaria across the Greater Mekong subregion, Malaria Journal, vol.13, issue.1, p.286, 2014. ,
DOI : 10.1371/journal.pmed.1001642
Countries race to contain resistance to key antimalarial, The Lancet, vol.374, issue.9686, pp.277-80, 2009. ,
DOI : 10.1016/S0140-6736(09)61349-0
Plasmodium falciparum field isolates from areas of repeated emergence of drug resistant malaria show no evidence of hypermutator phenotype, Infection, Genetics and Evolution, vol.30, pp.318-340, 2015. ,
DOI : 10.1016/j.meegid.2014.12.010
Genetic architecture of artemisinin-resistant Plasmodium falciparum, Nature Genetics, vol.4, issue.3, pp.226-260, 2015. ,
DOI : 10.1111/j.1365-294X.2005.02553.x
Countrywide Survey Shows Very High Prevalence of Plasmodium falciparum Multilocus Resistance Genotypes in Cambodia, Antimicrobial Agents and Chemotherapy, vol.49, issue.8, pp.3147-52, 2005. ,
DOI : 10.1128/AAC.49.8.3147-3152.2005
URL : https://hal.archives-ouvertes.fr/pasteur-00590990
High Heritability of Malaria Parasite Clearance Rate Indicates a Genetic Basis for Artemisinin Resistance in Western Cambodia, The Journal of Infectious Diseases, vol.201, issue.9, pp.1326-1356, 2010. ,
DOI : 10.1086/651562
Increased Tolerance to Artemisinin in Plasmodium falciparum Is Mediated by a Quiescence Mechanism, Antimicrobial Agents and Chemotherapy, vol.54, issue.5, pp.1872-1879, 2010. ,
DOI : 10.1128/AAC.01636-09
Exploring the Contribution of Candidate Genes to Artemisinin Resistance in Plasmodium falciparum, Antimicrobial Agents and Chemotherapy, vol.54, issue.7, pp.2886-92, 2010. ,
DOI : 10.1128/AAC.00032-10
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria, Nature, vol.10, issue.7481, pp.50-55, 2014. ,
DOI : 10.1038/nature12876
URL : https://hal.archives-ouvertes.fr/pasteur-00921203
Open randomized trial of oral artemether alone and a sequen? tial combination with mefloquine for acute uncomplicated falciparum malaria, Am J Trop Med Hyg, vol.56, pp.613-620, 1997. ,
by Extended Artemisinin Pressure, Emerging Infectious Diseases, vol.21, issue.10, pp.1733-1774, 2015. ,
DOI : 10.3201/eid2110.150682
A worldwide map of Plasmodium falciparum artemisinin resistance, N Engl J Med, p.2016 ,
Mathematical modelling of the chemotherapy of Plasmodium falciparum malaria with artesunate: postulation of ???dormancy???, a partial cytostatic effect of the drug, and its implication for treatment regimens, Parasitology, vol.121, issue.3, pp.237-283, 2000. ,
DOI : 10.1017/S0031182099006332
Proliferation/quiescence: the controversial "aller-retour", Cell Division, vol.6, issue.1, p.10, 2011. ,
DOI : 10.1002/yea.320090503
URL : https://hal.archives-ouvertes.fr/hal-00592485
Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state, Proceedings of the National Academy of Sciences, vol.109, issue.47, pp.3278-87, 2012. ,
DOI : 10.1073/pnas.1209823109
Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures, Nature Medicine, vol.13, issue.3, pp.307-319, 2014. ,
DOI : 10.1007/s00125-005-1694-6
Reduced Artemisinin Susceptibility of Plasmodium falciparum Ring Stages in Western Cambodia, Antimicrobial Agents and Chemotherapy, vol.57, issue.2, pp.914-937, 2013. ,
DOI : 10.1128/AAC.01868-12
Parasites In Vitro, Journal of Infectious Diseases, vol.212, issue.3, pp.426-460, 2015. ,
DOI : 10.1093/infdis/jiv048
Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion, Proceedings of the National Academy of Sciences, vol.108, issue.28, pp.11405-11415, 2011. ,
DOI : 10.1073/pnas.1104063108
Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance, PLOS Biology, vol.13, issue.4, p.1002132, 2015. ,
DOI : 10.1371/journal.pbio.1002132.s014
Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum, Nature Communications, vol.13, p.10111, 2015. ,
DOI : 10.1038/ncomms10111
Artemisinin-Resistant Plasmodium falciparum Parasites Exhibit Altered Patterns of Development in Infected Erythrocytes, Antimicrobial Agents and Chemotherapy, vol.59, issue.6, pp.3156-67, 2015. ,
DOI : 10.1128/AAC.00197-15
Intrahost modeling of artemisinin resistance in Plasmodium falciparum, Proceedings of the National Academy of Sciences, vol.108, issue.1, pp.397-402, 2011. ,
DOI : 10.1073/pnas.1006113108
: Duration, Recovery Rates, and Implications in Treatment Failure, The Journal of Infectious Diseases, vol.202, issue.9, pp.1362-1370, 2010. ,
DOI : 10.1086/656476
Fatty Acid Synthesis and Pyruvate Metabolism Pathways Remain Active in Dihydroartemisinin-Induced Dormant Ring Stages of Plasmodium falciparum, Antimicrobial Agents and Chemotherapy, vol.58, issue.8, pp.4773-81, 2014. ,
DOI : 10.1128/AAC.02647-14
K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates, Science, vol.347, issue.6220, pp.428-459, 2015. ,
DOI : 10.1126/science.1260867
Mutations in Plasmodium falciparum K13 propeller gene from Bangladesh (2009???2013), Malaria Journal, vol.13, issue.1, p.431, 2014. ,
DOI : 10.1186/1475-2875-8-31
Following Artemisinin Treatment, Journal of Infectious Diseases, vol.212, issue.10, pp.1629-1664, 2015. ,
DOI : 10.1093/infdis/jiv249
Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia, Journal of Infectious Diseases, vol.211, issue.5, pp.670-679, 2015. ,
DOI : 10.1093/infdis/jiu491
Molecular Assessment of Artemisinin Resistance Markers, Polymorphisms in the K13 Propeller, and a Multidrug-Resistance Gene in the Eastern and Western Border Areas of Myanmar, Clinical Infectious Diseases, vol.60, issue.8, pp.1208-1223, 2015. ,
DOI : 10.1093/cid/ciu1160
Plasmodium falciparum Founder Populations in Western Cambodia Have Reduced Artemisinin Sensitivity In Vitro, Antimicrobial Agents and Chemotherapy, vol.58, issue.8, pp.4935-4942, 2014. ,
DOI : 10.1128/AAC.03055-14
Artemisinin resistance in Plasmodium falciparum, The Lancet Infectious Diseases, vol.14, issue.6, pp.449-50, 2014. ,
DOI : 10.1016/S1473-3099(14)70777-7
Understanding artemisinin resistance, Science, vol.347, issue.6220, pp.373-377, 2015. ,
DOI : 10.1126/science.aaa4102
K13?propeller polymorphisms in Plasmodium falciparum para? sites from sub?Saharan Africa, J Infect Dis, vol.211, pp.1352-1357, 2015. ,
Absence of Putative Artemisinin Resistance Mutations Among Plasmodium falciparum in Sub-Saharan Africa: A Molecular Epidemiologic Study, Journal of Infectious Diseases, vol.211, issue.5, pp.680-688, 2014. ,
DOI : 10.1093/infdis/jiu467
in Africa?: Table 1., Journal of Infectious Diseases, vol.213, issue.1, pp.165-171, 2016. ,
DOI : 10.1093/infdis/jiv414
Slow clearance of Plasmodium falciparum in severe pediatric Malaria, Uganda, Emerg Infect Dis, vol.21, pp.2011-20131237, 2015. ,
Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system, Nature Biotechnology, vol.32, issue.8, pp.819-840, 2014. ,
DOI : 10.1016/S1473-3099(13)70252-4
Understanding artemisinin-resistant malaria, Current Opinion in Infectious Diseases, vol.28, issue.5, pp.417-442, 2015. ,
DOI : 10.1097/QCO.0000000000000199
Reduced Polymorphism in the Kelch Propeller Domain in Plasmodium vivax Isolates from Cambodia, Antimicrobial Agents and Chemotherapy, vol.59, issue.1, pp.730-733, 2015. ,
DOI : 10.1128/AAC.03908-14
The kelch repeat superfamily of proteins: propellers of cell function, Trends in Cell Biology, vol.10, issue.1, pp.17-24, 2000. ,
DOI : 10.1016/S0962-8924(99)01673-6
Crystal structure analysis of Kelch protein from Plasmodium falciparum ,
Drug resistance genomics of the antimalarial drug artemisinin, Genome Biology, vol.12, issue.11, p.544, 2014. ,
DOI : 10.1186/s13059-014-0544-6
A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria, Nature, vol.103, issue.7549, pp.683-690, 2015. ,
DOI : 10.1038/nature14412
Structural Basis for Defects of Keap1 Activity Provoked by Its Point Mutations in Lung Cancer, Molecular Cell, vol.21, issue.5, pp.689-700, 2006. ,
DOI : 10.1016/j.molcel.2006.01.013
Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities, Nature, vol.25, issue.7383, pp.98-102, 2012. ,
DOI : 10.1038/nature10814
Plasmodium falciparum endoplasmic reticulum?resident calcium binding protein is a possible target of synthetic antimalarial endoperoxides, N?89 and N?251, J Proteome Res, vol.11, pp.5704-5715, 2012. ,
Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance, Science, vol.347, issue.6220, pp.431-436, 2015. ,
DOI : 10.1126/science.1260403
Subcellular Localization of a Fluorescent Artemisinin Derivative to Endoplasmic Reticulum, Organic Letters, vol.12, issue.7, pp.1420-1423, 2010. ,
DOI : 10.1021/ol902890j
Intracellular Eukaryotic Parasites Have a Distinct Unfolded Protein Response, PLoS ONE, vol.4, issue.4, p.19118, 2011. ,
DOI : 10.1371/journal.pone.0019118.s006
URL : http://doi.org/10.1371/journal.pone.0019118
Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids, Free Radical Biology and Medicine, vol.52, issue.6, pp.973-82, 2012. ,
DOI : 10.1016/j.freeradbiomed.2011.11.038
Modulation of the Akt Pathway Reveals a Novel Link with PERK/eIF2??, which Is Relevant during Hypoxia, PLoS ONE, vol.12, issue.7, p.69668, 2013. ,
DOI : 10.1371/journal.pone.0069668.s005
eukaryotic initiation factor-2?? kinase IK2 controls the latency of sporozoites in the mosquito salivary glands, The Journal of Experimental Medicine, vol.21, issue.7, pp.1465-74, 2010. ,
DOI : 10.1371/journal.pone.0001570
The proliferating cell hypothesis: a metabolic framework for Plasmodium growth and development, Trends in Parasitology, vol.30, issue.4, pp.170-175, 2014. ,
DOI : 10.1016/j.pt.2014.02.001
Atypical lipid composition in the purified relict plastid (apicoplast) of malaria parasites, Proceedings of the National Academy of Sciences, vol.110, issue.18, pp.7506-7517, 2013. ,
DOI : 10.1073/pnas.1301251110
URL : https://hal.archives-ouvertes.fr/hal-00839109
Endoplasmic Reticulum PI(3)P Lipid Binding Targets Malaria Proteins to the Host Cell, Cell, vol.148, issue.1-2, pp.201-213, 2012. ,
DOI : 10.1016/j.cell.2011.10.051
Phosphatidylinositol 3-Phosphate, an Essential Lipid in Plasmodium, Localizes to the Food Vacuole Membrane and the Apicoplast, Eukaryotic Cell, vol.9, issue.10, pp.1519-1549, 2010. ,
DOI : 10.1128/EC.00124-10
Mitochondria and apicoplast of Plasmodium falciparum: Behaviour on subcellular fractionation and the implication, Mitochondrion, vol.7, issue.1-2, pp.125-157, 2007. ,
DOI : 10.1016/j.mito.2006.11.021
Fatty acid metabolism in the Plasmodium apicoplast: Drugs, doubts and knockouts, Molecular and Biochemical Parasitology, vol.199, issue.1-2, pp.34-50, 2015. ,
DOI : 10.1016/j.molbiopara.2015.03.004
Metabolic maps and functions of the Plasmodium falciparum apicoplast, Nature Reviews Microbiology, vol.16, issue.3, pp.203-219, 2004. ,
DOI : 10.1093/nar/gkg081
Artemisinin-resistant Plasmodium falciparum clinical isolates can infect diverse mosquito vectors of Southeast Asia and Africa, Nature Communications, vol.48, p.8614, 2015. ,
DOI : 10.1038/ncomms9614
Epidemiology of drug-resistant malaria, The Lancet Infectious Diseases, vol.2, issue.4, pp.209-227, 2002. ,
DOI : 10.1016/S1473-3099(02)00239-6
Resistance to antimalarial compounds: Methods and applications, Drug Resistance Updates, vol.12, issue.1-2, pp.42-50, 2009. ,
DOI : 10.1016/j.drup.2009.01.001
Transporters as mediators of drug resistance in Plasmodium falciparum, International Journal for Parasitology, vol.40, issue.10, pp.1109-1127, 2010. ,
DOI : 10.1016/j.ijpara.2010.04.001
The ABCs of multidrug resistance in malaria, Trends in Parasitology, vol.26, issue.9, pp.440-446, 2010. ,
DOI : 10.1016/j.pt.2010.05.002
Role of different Pfcrt and Pfmdr?1 mutations in conferring resistance to antimalaria drugs in Plasmodium falciparum, Malar Res Treat, vol.2014, p.950424, 2014. ,
Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics, Cellular and Molecular Life Sciences, vol.101, issue.3, pp.1967-95, 2012. ,
DOI : 10.1007/s00018-011-0906-0
Role of Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes on In Vitro Chloroquine Resistance in Isolates of Plasmodium falciparum from Thailand, American Journal of Tropical Medicine and Hygiene, vol.85, issue.4, pp.606-617, 2011. ,
DOI : 10.4269/ajtmh.2011.11-0108
Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number, The Lancet, vol.364, issue.9432, pp.438-485, 2004. ,
DOI : 10.1016/S0140-6736(04)16767-6
MMV in partnership: the Eurartesim?? experience, Malaria Journal, vol.12, issue.1, p.211, 2013. ,
DOI : 10.1128/AAC.01879-12
Genetic Investigation of Tricarboxylic Acid Metabolism during the Plasmodium falciparum Life Cycle, Cell Reports, vol.11, issue.1, pp.164-74, 2015. ,
DOI : 10.1016/j.celrep.2015.03.011
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer, Redox Biology, vol.1, issue.1, pp.45-54, 2013. ,
DOI : 10.1016/j.redox.2012.10.001
PI3K is a key molecule in the Nrf2-mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells, FEBS Letters, vol.31, issue.2-3, pp.181-185, 2003. ,
DOI : 10.1016/S0014-5793(03)00517-9
PERK and PKR: Old kinases learn new tricks, Cell Cycle, vol.7, issue.9, pp.1146-50, 2008. ,
DOI : 10.4161/cc.7.9.5811
PfeIK1, a eukaryotic initiation factor 2?? kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation, Malaria Journal, vol.8, issue.1, p.99, 2009. ,
DOI : 10.1186/1475-2875-8-99
PK4, a eukaryotic initiation factor 2??(eIF2??) kinase, is essential for the development of the erythrocytic cycle of Plasmodium, Proceedings of the National Academy of Sciences, vol.109, issue.10, pp.3956-61, 2012. ,
DOI : 10.1073/pnas.1121567109
Endoplasmic Reticulum Stress Triggers Gametocytogenesis in the Malaria Parasite, Journal of Biological Chemistry, vol.289, issue.24, pp.16662-74, 2014. ,
DOI : 10.1074/jbc.M114.551549
Cyclin-dependent kinase homologues of Plasmodium falciparum, International Journal for Parasitology, vol.32, issue.13, pp.1575-85, 2002. ,
DOI : 10.1016/S0020-7519(02)00186-8