L. Ware and M. Matthay, The Acute Respiratory Distress Syndrome, New England Journal of Medicine, vol.342, issue.18, pp.1334-1383, 2000.
DOI : 10.1056/NEJM200005043421806

G. Rubenfeld, E. Caldwell, E. Peabody, J. Weaver, D. Martin et al., Incidence and Outcomes of Acute Lung Injury, New England Journal of Medicine, vol.353, issue.16, pp.1685-93, 2005.
DOI : 10.1056/NEJMoa050333

J. Hogg, Neutrophil kinetics and lung injury, Physiol Rev, vol.67, pp.1249-95, 1987.

K. Yoshida, R. Kondo, Q. Wang, and C. Doerschuk, Neutrophil Cytoskeletal Rearrangements during Capillary Sequestration in Bacterial Pneumonia in Rats, American Journal of Respiratory and Critical Care Medicine, vol.174, issue.6, pp.689-98, 2006.
DOI : 10.1164/rccm.200502-276OC

G. Andonegui, C. Bonder, F. Green, S. Mullaly, L. Zbytnuik et al., Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs A published erratum appears, J Clin Invest. J Clin Invest, vol.111112, pp.1011-201264, 2003.

P. Yodice, M. Astiz, B. Kurian, R. Lin, and E. Rackow, Neutrophil rheologic changes in septic shock., American Journal of Respiratory and Critical Care Medicine, vol.155, issue.1, pp.38-42, 1997.
DOI : 10.1164/ajrccm.155.1.9001286

G. Ibbotson, C. Doig, J. Kaur, V. Gill, L. Ostrovsky et al., Functional ? 4 -integrin: A newly identified pathway of neutrophil recruitment in critically ill septic patients, Nature Medicine, vol.7, issue.4, pp.465-70, 2001.
DOI : 10.1038/86539

S. Lewis, D. Treacher, L. Bergmeier, S. Brain, D. Chambers et al., Plasma from Patients with Sepsis Up-Regulates the Expression of CD49d and CD64 on Blood Neutrophils, American Journal of Respiratory Cell and Molecular Biology, vol.40, issue.6, pp.724-756, 2009.
DOI : 10.1165/rcmb.2008-0252OC

M. Hirsh, E. Mahamid, Y. Bashenko, I. Hirsh, and M. Krausz, OVEREXPRESSION OF THE HIGH-AFFINITY Fc?? RECEPTOR (CD64) IS ASSOCIATED WITH LEUKOCYTE DYSFUNCTION IN SEPSIS, Shock, vol.16, issue.2, pp.102-110, 2001.
DOI : 10.1097/00024382-200116020-00003

M. Nishino, H. Tanaka, H. Ogura, Y. Inoue, T. Koh et al., Serial Changes in Leukocyte Deformability and Whole Blood Rheology in Patients With Sepsis or Trauma, The Journal of Trauma: Injury, Infection, and Critical Care, vol.59, issue.6, pp.1425-1456, 2005.
DOI : 10.1097/01.ta.0000197356.83144.72

A. Skoutelis, V. Kaleridis, G. Athanassiou, K. Kokkinis, Y. Missirlis et al., Neutrophil deformability in patients with sepsis, septic shock, and adult respiratory distress syndrome, Critical Care Medicine, vol.28, issue.7, pp.2355-2364, 2000.
DOI : 10.1097/00003246-200007000-00029

A. Lavkan, M. Astiz, and E. Rackow, Effects of proinflammatory cytokines and bacterial toxins on neutrophil rheologic properties, Critical Care Medicine, vol.26, issue.10, pp.1677-82, 1998.
DOI : 10.1097/00003246-199810000-00021

B. Nandi and S. Behar, Regulation of neutrophils by interferon-?? limits lung inflammation during tuberculosis infection, The Journal of Experimental Medicine, vol.153, issue.11, pp.2251-62, 2011.
DOI : 10.1111/j.1600-065X.2010.01000.x

W. Lam, M. Rosenbluth, and D. Fletcher, Chemotherapy exposure increases leukemia cell stiffness, Blood, vol.109, issue.8, pp.3505-3513, 2007.
DOI : 10.1182/blood-2006-08-043570

G. Worthen, B. Schwab, E. Elson, and G. Downey, Mechanics of stimulated neutrophils: cell stiffening induces retention in capillaries, Science, vol.245, issue.4914, pp.183-189, 1989.
DOI : 10.1126/science.2749255

E. Drost and W. Macnee, Potential role of IL-8, platelet-activating factor and TNF-?? in the sequestration of neutrophils in the lung: effects on neutrophil deformability, adhesion receptor expression, and chemotaxis, European Journal of Immunology, vol.387, issue.2, pp.393-403, 2002.
DOI : 10.1002/1521-4141(200202)32:2<393::AID-IMMU393>3.0.CO;2-5

A. Linden, Neutrophils, interleukin-17A and lung disease, European Respiratory Journal, vol.25, issue.1, pp.159-72, 2005.
DOI : 10.1183/09031936.04.00032904

Y. Inoue, H. Tanaka, H. Ogura, I. Ukai, K. Fujita et al., A Neutrophil Elastase Inhibitor, Sivelestat, Improves Leukocyte Deformability in Patients With Acute Lung Injury, The Journal of Trauma: Injury, Infection, and Critical Care, vol.60, issue.5, pp.936-979, 2006.
DOI : 10.1097/01.ta.0000217271.25809.a0

A. Skoutelis, V. Kaleridis, C. Gogos, G. Athanassiou, Y. Missirlis et al., EFFECT OF CYTOKINES AND COLONY-STIMULATING FACTORS ON PASSIVE POLYMORPHONUCLEAR LEUKOCYTE DEFORMABILITY IN VITRO, Cytokine, vol.12, issue.11, pp.1737-1777, 2000.
DOI : 10.1006/cyto.2000.0761

W. Westlin, J. Kiely, and M. Gimbrone, Interleukin-8 induces changes in human neutrophil actin conformation and distribution: relationship to inhibition of adhesion to cytokine-activated endothelium, J Leukoc Biol, vol.52, pp.43-51, 1992.

V. Ranieri, G. Rubenfeld, B. Thompson, N. Ferguson, E. Caldwell et al., Acute respiratory distress syndrome: the Berlin Definition, JAMA, vol.307, pp.2526-2559, 2012.

P. Preira, M. Valignat, J. Bico, O. Théodoly, F. Lautenschläger et al., Single cell rheometry with a microfluidic constriction: quantitative control of friction and fluid leaks between cell and channel walls The regulatory role of cell mechanics for migration of differentiating myeloid cells, Biomicrofluidics. Proc Natl Acad Sci U S A, vol.7106, pp.24111-2515696, 2009.

J. Ng, I. Gitlin, A. Stroock, and G. Whitesides, Components for integrated poly(dimethylsiloxane) microfluidic systems, ELECTROPHORESIS, vol.23, issue.20, pp.3461-73, 2002.
DOI : 10.1002/1522-2683(200210)23:20<3461::AID-ELPS3461>3.0.CO;2-8

P. Robert, M. Canault, C. Farnarier, A. Nurden, C. Grosdidier et al., A Novel Leukocyte Adhesion Deficiency III Variant: Kindlin-3 Deficiency Results in Integrin- and Nonintegrin-Related Defects in Different Steps of Leukocyte Adhesion, The Journal of Immunology, vol.186, issue.9, pp.5273-83, 2011.
DOI : 10.4049/jimmunol.1003141

E. Azoulay, J. Lambert, and D. Mokart, Diagnostic Strategy for Hematology and Oncology Patients with Acute Respiratory Failure, American Journal of Respiratory and Critical Care Medicine, vol.183, issue.2, pp.279-80, 2011.
DOI : 10.1164/ajrccm.183.2.279b

D. Mokart, B. Guery, R. Bouabdallah, C. Martin, J. Blache et al., Deactivation of Alveolar Macrophages in Septic Neutropenic ARDS*, Chest, vol.124, issue.2, pp.644-52, 2003.
DOI : 10.1378/chest.124.2.644

D. Kreisel, R. Nava, W. Li, B. Zinselmeyer, B. Wang et al., In vivo two-photon imaging reveals monocyte-dependent neutrophil extravasation during pulmonary inflammation, Proceedings of the National Academy of Sciences, vol.107, issue.42, pp.18073-18081, 2010.
DOI : 10.1073/pnas.1008737107

O. Dea, K. Dokpesi, J. Tatham, K. Wilson, M. Takata et al., Regulation of monocyte subset proinflammatory responses within the lung microvasculature by the p38 MAPK/MK2 pathway, American Journal of Physiology - Lung Cellular and Molecular Physiology, vol.301, issue.5, pp.812-833, 2011.
DOI : 10.1152/ajplung.00092.2011

S. Volpe, S. Thelen, T. Pertel, M. Lohse, and M. Thelen, Polarization of Migrating Monocytic Cells Is Independent of PI 3-Kinase Activity, PLoS ONE, vol.5, issue.4, p.10159, 2010.
DOI : 10.1371/journal.pone.0010159.s007

S. Iyer, R. Agrawal, C. Thompson, S. Thompson, J. Barton et al., Phospholipase D1 Regulates Phagocyte Adhesion, The Journal of Immunology, vol.176, issue.6, pp.3686-96, 2006.
DOI : 10.4049/jimmunol.176.6.3686

Y. Shyy, L. Wickham, J. Hagan, H. Hsieh, Y. Hu et al., Human monocyte colony-stimulating factor stimulates the gene expression of monocyte chemotactic protein-1 and increases the adhesion of monocytes to endothelial monolayers., Journal of Clinical Investigation, vol.92, issue.4, pp.1745-51, 1993.
DOI : 10.1172/JCI116762

Y. Yen, F. Liao, C. Hsiao, C. Kao, Y. Chen et al., Modeling the Early Events of Severe Acute Respiratory Syndrome Coronavirus Infection In Vitro, Journal of Virology, vol.80, issue.6, pp.2684-93, 2006.
DOI : 10.1128/JVI.80.6.2684-2693.2006

S. Yang, P. Chung, C. Ho, C. Kuo, M. Hung et al., Propofol Inhibits Superoxide Production, Elastase Release, and Chemotaxis in Formyl Peptide-Activated Human Neutrophils by Blocking Formyl Peptide Receptor 1, The Journal of Immunology, vol.190, issue.12, pp.6511-6520, 2013.
DOI : 10.4049/jimmunol.1202215

E. Abraham, A. Anzueto, G. Gutierrez, S. Tessler, S. Pedro et al., Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock, The Lancet, vol.351, issue.9107, pp.929-962, 1998.
DOI : 10.1016/S0140-6736(05)60602-2

N. Maniatis, A. Sfika, I. Nikitopoulou, A. Vassiliou, C. Magkou et al., ACID-INDUCED ACUTE LUNG INJURY IN MICE IS ASSOCIATED WITH P44/42 AND C-JUN N-TERMINAL KINASE ACTIVATION AND REQUIRES THE FUNCTION OF TUMOR NECROSIS FACTOR ?? RECEPTOR I, Shock, vol.38, issue.4, pp.381-387, 2012.
DOI : 10.1097/SHK.0b013e3182690ea2

G. Slotman, The Systemic Mediator-Associated Response Test Identifies Patients in Failed Sepsis Clinical Trials Among Whom Novel Drugs Reduce Mortality, The Journal of Trauma: Injury, Infection, and Critical Care, vol.71, issue.5, pp.1406-1420, 2011.
DOI : 10.1097/TA.0b013e3182159c61

J. Deree, J. Martins, T. De-campos, J. Putnam, W. Loomis et al., Pentoxifylline Attenuates Lung Injury and Modulates Transcription Factor Activity in Hemorrhagic Shock, Journal of Surgical Research, vol.143, issue.1, pp.99-108, 2007.
DOI : 10.1016/j.jss.2007.03.083

N. Okayama, Y. Kakihana, D. Setoguchi, T. Imabayashi, T. Omae et al., Clinical effects of a neutrophil elastase inhibitor, sivelestat, in patients with acute respiratory distress syndrome, Journal of Anesthesia, vol.157, issue.Suppl, pp.6-10, 2006.
DOI : 10.1007/s00540-005-0362-9

M. Hayakawa, K. Katabami, T. Wada, M. Sugano, H. Hoshino et al., SIVELESTAT (SELECTIVE NEUTROPHIL ELASTASE INHIBITOR) IMPROVES THE MORTALITY RATE OF SEPSIS ASSOCIATED WITH BOTH ACUTE RESPIRATORY DISTRESS SYNDROME AND DISSEMINATED INTRAVASCULAR COAGULATION PATIENTS, Shock, vol.33, issue.1, pp.14-22, 2010.
DOI : 10.1097/SHK.0b013e3181aa95c4